1,958 research outputs found
Interview with Jacqueline DeGroot
No full textJacqueline DeGroot, author of Climax and Worth Any Price, discusses how she came to be a writer, her writing process and sources of inspiration, and her experiences with self-publishing
Jacqueline Woodson: 2023 Irma Black Award Silver Medal Acceptance Speech
No full textAuthor Jacqueline Woodson gives an acceptance speech for The World Belonged to Us, illustrated by Leo Espinosa (Penguin)https://educate.bankstreet.edu/irma_black_awards/1011/thumbnail.jp
Leslie Behm interviews essayist and fantasy writer Jacqueline Carey
No full textEssayist and fantasy writer Jacqueline Carey talks about the meaning of the title of her Kushiel Trilogy, how she became an author, her work in progress. She also gives advice to aspiring authors. Carey is interviewed by Michigan State University librarian Leslie Behm. Part of the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
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Jacqueline Barnitz: 40 Years of Publications
No full textJacqueline Barnitz: 40 Years of Publications
Jacqueline Barnitz is responsible for establishing modern Latin American art as an area of concentration
within art history at the University of Texas at Austin, where she has taught now for 25 years. She's a
major reason why UT Austin is known as the best place in the nation for studying modern Latin American
art. A notable record of publication accompanies her career as a distinguished educator. In fact, her
interest in Latin American art goes back to her tenure as an art critic in New York for the periodicals Art
Voices (1964-1965) and Arts Magazine (1964-1975). Additionally, she's been the curator of numerous art
exhibitions and, subsequently, the author of many exhibition catalogs. In 2000 UT Press published her
much-anticipated and seminal book Twentieth-Century Art of Latin America, which quickly became the
textbook on the subject. We present this display of selected publications as a tribute to her outstanding
contributions to the university and to the field of art history.UT Librarie
Fumarate hydratase deficient renal cell carcinoma: a retrospective study performed at NHLS Universitas Academic laboratories, 2001 to 2017
No full textDissertation (M.Med.(Anatomical Pathology))--University of the Free State, 2021Background: Fumarate hydratase deficient renal cell carcinoma (FH deficient RCC) has, in recent years, been described as part of a morphologic spectrum of renal tumours associated with hereditary leiomyomatosis and renal cell carcinoma (HLCRCC) syndrome and is currently recognized as a distinct entity in the 2013 International Society of Urological Pathology (ISUP) Vancouver classification of renal tumours and is included in the 2016 World Health Organization (WHO) classification. FH deficient RCC is an aggressive neoplasm which often presents at a high pathologic stage, with local and distant metastases at the time of diagnosis. FH deficient RCC has a wide variety of morphological patterns, however, the presence of pattern multiplicity, sarcomatoid/rhabdoid morphology and the presence of characteristic nuclear features, i.e. nuclei with prominent viral inclusion-like macronucleoli and perinuclear halos should prompt genetic testing of the tumour. Characteristic immunohistochemical staining patterns, i.e. loss of cytoplasmic expression of fumarate hydratase (FH) and aberrant nuclear expression of S-(2-succino)-cyteine (2SC) have a 100% positive predictive value for identifying FH deficient RCC, however, only FH is available for commercial use. Retention of cytoplasmic staining for FH does not exclude FH deficient RCC since the gene may still be functional in missense variants of the FH gene. To our knowledge, there is presently no published research regarding FH deficient RCC and its association with HLRCC syndrome in Africa. The impact of this disorder in South African patients, is therefore unknown. Aim: The aim of this study was to determine the number and profile of patients with FH deficient RCC seen by the Department of Anatomical Pathology, University of the Free State over a 17-year period, from 1 January 2001 to 31 December 2017. Methods: A retrospective, cross-sectional study was performed. All cases of primary renal cell carcinoma and RCC subtypes diagnosed between 1 January 2001 and 31 December 2017 were included. An immunohistochemical stain for FH was performed on all the cases. All the cases with the typical phenotype for FH deficient RCC were submitted for molecular analysis and genotyping. Results: 172 patients were included in the study. Ninety (52.33%) were male and 82 (47.67%) were female. The mean age at presentation was 54.2 years and most patients presented in the 5th to 6th decades of life. All cases showed retained cytoplasmic staining with FH. One (0.58%) case of FH deficient RCC with the characteristic phenotype and a missense mutation in Exon 7 of the FH gene was identified. The patient was a 53-year-old black female and no information regarding the presence of uterine leiomyomas or family history of RCC was available. Conclusion: All cases of RCC displaying the typical phenotype of FH deficient RCC (whether immunolabeling for FH is retained or lost) should be submitted for molecular testing in order to identify patients with HLRCC syndrome or confirm the diagnosis of sporadic FH deficient RCC to minimize morbidity and mortality in such patients and their families.National Health Laboratory Service Research Trus
The profile of genetic mutations in pheochromocytomas and paragangliomas in South African patients
No full textBackground: Pheochromocytomas (PCCs) are rare neoplasms of the adrenal glands. Extraadrenal pheochromocytomas, or paragangliomas (PGLs), most commonly involve the carotid body and middle ear. Both germline and somatic variants are associated with their pathogenesis, and identification of a specific genetic variant guides clinical management in patients and their families. The genetic heterogeneity of PCCs/PGLs is distinct, creating the possibility of personalized, genomics-driven therapy. Next-generation sequencing allows massive parallel sequencing of all genes of interest in a single, cost-effective run. Internationally, extensive research has been done regarding the genetic make-up of PCCs/ PGLs, and the genes most commonly involved include SDHB, SDHD, RET, and VHL. Aim: To describe the genetic variants in PCCs/PGLs in the South African population. Methods: A retrospective study was performed. Ninety eight of the most recent cases with sufficient tissue available in wax blocks were included. Manual DNA extraction and subsequent DNA sequencing was performed, and 16 genes of interest were assessed for possible variants. These included EGLN1 , EPAS1 , FH , HRAS , IDH1 , KIF1B , MAX , NF1 , RET , SDHA , SDHAF2 , SDHB , SDHC , SDHD , TMEM127 and VHL . Results: Thirty one of the 98 cases were sequenced. In the remaining cases the DNA quality was inadequate. Ninety three variants were detected with 32 synonymous variants, 54 missense variants, and 7 truncating variants. Nine pathogenic or likely pathogenic variants were identified in total, involving the NF1, KIF1B, RET, SDHB and TMEM127 genes. Most variants identified were predicted benign, likely benign and benign variants or variants of unknown significance. Conclusion: The profile of pathogenic or likely pathogenic variants identified in this study differs somewhat from that described in the literature with NF1 and KIF1B most commonly involved. In addition, no pathogenic SDHD or VHL variants were found in this study. However, the number of patient’s is small and additional data are required to determine the true genetic profile in South African patients.University of the Free State, Department of Surgery Research Fun
First person – Jacqueline Weidner
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open (BiO), helping early-career researchers promote themselves alongside their papers. Jacqueline Weidner is first author on ‘Hormones as adaptive control systems in juvenile fish’, published in BiO. Jacqueline conducted the research described in this article while a PhD student at the University of Bergen, Norway. She is now an assistant professor at the Western Norway University of Applied Sciences, Norway, investigating sexual selection and modelling of evolutionary patterns
NUT midline carcinoma in the state sector of the Free State province, South Africa
No full textBackground: NUT midline carcinoma (NMC) is a recently described, rare tumour that can easily be mistaken for a number of other tumours if a NUT immunohistochemical stain is not performed. The tumour is caused by a translocation involving the NUT gene and most cases involve BRD4 - NUT t(15;19) which results in loss of differentiation and uninhibited proliferation. The loss of differentiation is responsible for the monomorphic, primitive morphology of the tumour. The reporting Pathologist should have a high index of suspicion as the tumour shows positively for numerous immunohistochemical markers that vary from case to case. Positivity for CD34, which is unusual in carcinomas, together with positivity for cytokeratins, is a strong diagnostic clue that should prompt testing for the tumour. Previously thought to occur only in midline structures and young patients, recent research has proven the occurrence in a wider age distribution and outside the midline. This tumour is exceptionally aggressive, with only isolated survivors and early identification and aggressive treatment is needed. No research on NMC has been done in South Africa and there is only one case report from the rest of Africa. The incidence of this tumour in South Africa is therefore unknown. Aim: The aim of this study was to determine the number of cases of NMC seen over a twelve year period by the Department of Anatomical Pathology, University of the Free State and National Health Laboratory Service and to describe the demographic features of any patients identified. Methods: A retrospective study was performed. All undifferentiated malignant tumours and tumours with evidence of squamous differentiation from the head, neck and thorax seen between 1 January 2005 and 31 December 2016 were included. A NUT immunohistochemical stain was performed on all cases. The stain was regarded as positive if there was speckled nuclear staining in more than 50% of the tumour cells. Results: Four hundred and ninety eight cases were included in the study of which 424 (85.1%) were male and 74 (14.9%) were female. The mean age was 58.6 years. Only one positive case was identified. The patient was a 30-year-old female with a lung mass and lymph node metastases. Conclusion: This study confirms the rarity of this entity. Additional research is needed in other provinces of South Africa, including the private sector to provide a comprehensive patient profile of NMC in South Africa.University of the Free State, Department of Surgery Research Fun
The quality of specimens obtained by fine-needle aspiration biopsy : does training make a difference?
No full textCITATION: Goedhals, J., Thiart, J., Joubert, G. & Wright, C. 2012. The quality of specimens obtained by fine-needle aspiration biopsy : does training make a difference? South African Family Practice, 54(5):425-428.The original publication is available at http://www.safpj.co.zaBackground: The aim of this study was to determine the outcome of a one-hour training session on the correct technique of fine-needle aspiration biopsy (FNAB) by assessing adequacy of FNAB specimens received from clinicians at an academic hospital.
Method: Six clinicians were recruited and their FNABs assessed, six months prior to, and then again after, a one-hour training session in correct technique. Questionnaires were completed prior to the training session and after the subsequent six-month period, to determine the subjective assessment of the clinicians’ perceived value of the training on their aspiration technique.
Results: Five of the clinicians had never received training in FNAB technique. The adequacy of the aspirates for all six clinicians did not improve, although this was not statistically significant. They performed a median of 15.5 FNABs in the six months prior to training, and 13.5 FNABs in the six-month follow-up period. Five of the six clinicians subjectively perceived the quality of the aspirates to have improved, and all six recommended the training session to their colleagues.
Conclusion: No improvement was noted after training, but the number of FNABs performed per clinician was suboptimal. Previous studies have shown that clinicians performing relatively few aspirates perform poorly, even if they have received adequate training. The fact that all six would recommend the training session to colleagues is encouraging, and the authors recommend that formal training in FNAB technique should be included in the undergraduate medical curriculum.http://www.safpj.co.za/index.php/safpj/article/view/2139Publisher's versio
Jacqueline Risset. Scritture dell’istante
No full text“Born on 25th May 1936. Two specific desires: not to become an adult, and to write”. Jacqueline Risset (1936-2014) was a translator from French (Ponge, Sollers, the Tel Quel poets) and Italian (Dante, Machiavelli, Balestrini), as well as a well-known scholar for her work on Scève, Proust and Bataille. The aim of this volume is to analyse Risset’s poetic work, from the beginnings with textual writing in the experimentalism of Tel Quel, through a trajectory that, crossing Dante and Stilnovism through the translation of the Divine Comedy, led the author to the elaboration of a poetics centred on “privileged instants” that open “to the elsewhere”
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