177 research outputs found
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No full text© 2021, L. Cassidy, D. Hannibal, S. Semple, B. McCowan. This is an author produced version of a paper published in AMERICAN JOURNAL OF PRIMATOLOGY uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
Hands of Nature
No full textAs an artist, Cassidy has always held the belief that “Almost anything can be art if you look at it the right way.” Her main passion has always been ceramics but she enjoys all kinds of art because she can make anything into anything. She loves how there are no bounds for creativity in art, just endless possibilities. She says she often tries to push the boundaries in her art by creating larger and more intricate or with purpose. Her art work includes mostly functional pieces but she decorates them so they can be either functional or decorative or both. Her inspiration comes mostly from nature but she says she’d like to try to venture into abstract art in the near future as well.https://scholars.fhsu.edu/sacad_art/1034/thumbnail.jp
Leaves of Life
No full textAs an artist, Cassidy has always held the belief that “Almost anything can be art if you look at it the right way.” Her main passion has always been ceramics but she enjoys all kinds of art because she can make anything into anything. She loves how there are no bounds for creativity in art, just endless possibilities. She says she often tries to push the boundaries in her art by creating larger and more intricate or with purpose. Her art work includes mostly functional pieces but she decorates them so they can be either functional or decorative or both. Her inspiration comes mostly from nature but she says she’d like to try to venture into abstract art in the near future as well.https://scholars.fhsu.edu/sacad_art/1032/thumbnail.jp
Monkey 2
No full textAs an artist, Cassidy has always held the belief that “Almost anything can be art if you look at it the right way.” Her main passion has always been ceramics but she enjoys all kinds of art because she can make anything into anything. She loves how there are no bounds for creativity in art, just endless possibilities. She says she often tries to push the boundaries in her art by creating larger and more intricate or with purpose. Her art work includes mostly functional pieces but she decorates them so they can be either functional or decorative or both. Her inspiration comes mostly from nature but she says she’d like to try to venture into abstract art in the near future as well.https://scholars.fhsu.edu/sacad_art/1033/thumbnail.jp
ESTHER C. CASSIDY
No full textESTHER C. CASSIDY
Inducted: 1999
Citation: Science policy, physics, electrical engineering For leadership of NBS/NIST Congressional relations in turbulent years when existing NBS programs were proposed for elimination (and defended successfully) and major new programs including the Baldrige Awards, Manufacturing Extension Program and Advanced Technology Program were defined, established and implemented.
Tenure: 1955-1997
Birth: 1933, Upper Marlboro, Maryland
Education:
Manhattanville College, BA (Physics), 1955
Positions held:
Physical Scientist, Research and Development
Scientific Adviser to U.S. Representative Teno Roncalio (D-WY)
U.S. Department of Commerce Federal Women's Committee Representative
Director of Congressional and Legislative Affairs
Honors:
U.S. Department of Commerce: Silver Medal, 1970; Science and Technology Fellowship, 1973?74;
U.S. Department of Commerce and U.S. Energy Research and Development Administration Special Achievement and Incentive Awards
Memberships:
Institute of Electrical and Electronics Engineers (Senior Member)
American Physical Society
Electrostatics Society of America
Publications:
Author of many articles in science and engineering journals and several patents
Molecular modeling and simulation of bacterial chemosensory arrays
No full textThe movement of an organism in response to environmental chemical cues is known as chemotaxis. Motile bacteria use chemotaxis to navigate through their environments, enabling cells to efficiently locate favorable growing conditions while avoiding harmful ones. Central to this ability, bacteria posses a universally conserved sensory apparatus, known as the chemosensory array, which involves the clustering of thousands of proteins into a highly cooperative signaling network. The present dissertation will present my work using techniques in computational modeling and simulation to investigate the molecular structure and function of the bacterial chemosensory array. A brief overview of each chapter follows.
Chapter 1 provides an introduction to the systems-level features of chemotaxis in the model organism Escherichia coli as well as an overview of the molecular organization and function of the chemosensory array.
Chapter 2 gives an outline of the core methodologies used in my work, specifically all-atom molecular dynamics (MD) simulation and Molecular Dynamics Flexible Fitting (MDFF). In addition, two of the primary techniques used to analyze the MD simulations presented in this dissertation are sketched out, namely structural clustering based on root- mean-square displacement (RMSD) and Principal Component Analysis (PCA).
Chapter 3 reports my work, in collaboration with Peijun Zhang’s Lab, to investigate the structural and dynamical features of the extended chemosensory array. Using computational techniques to synthesize multi-scale structural data from X-ray crystallography and cryo-electron tomography (cryo-ET), an atomic model of the cytoplasmic portion of the chemosensory array from Thermotoga maritima is constructed and refined. Through the use of large-scale MD simulations, a novel conformational change in a key signaling protein is identified and subsequently shown to be critical for chemotaxis signaling in live E. coli cells.
Chapter 4 details the construction of an atomic model of a complete, transmembrane (TM) chemoreceptor. In particular, I use homology modeling and MD simulations, in- formed by biochemical and X-ray crystallographic data, to derive a model of the E. coli serine receptor (Tsr), including the previously uncharacterized TM four-helix bundle and HAMP domains. In addition, I report a series of MD simulations of a fragment of the resulting Tsr model, investigating the structural and dynamical effects of mutations on a key control cable residue. Preliminary MD simulations of the intact Tsr model are also presented.
Chapter 5 reports work in collaboration with Michael Eisenbach’s Lab at the Weizmann Institute, exploring the role of acetylation on CheY activation and the generation of clockwise (CW) flagellar motor rotation. Specifically, I present a series of MD simulations that investigate the effect of a hyperactivating mutation at a key acetylation site and offer a molecular explanation of acetylation-dependent generation of CW flagellar motor rotation.
I conclude with a brief description of recent work, expanding upon the results of the previous chapters, which has resulted in the first atomically resolved model of the E. coli transmembrane chemosensory array.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01The student, C. Cassidy, accepted the attached license on 2017-01-09 at 12:41.The student, C. Cassidy, submitted this Dissertation for approval on 2017-01-09 at 13:01.This Dissertation was approved for publication on 2017-01-10 at 08:48.DSpace SAF Submission Ingestion Package generated from Vireo submission #10534 on 2017-08-10 at 15:04:11Made available in DSpace on 2017-08-10T20:32:24Z (GMT). No. of bitstreams: 3
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Historic Costume Simulation and its Application
No full textThis study highlights the potential of new technology as a means to provide new possibility for costumes in fragile condition to be utilised. The aim of this study is to create accurate digital duplicates of costumes from historical sources, and to explore the possibility of developing them as an exhibitory and educational method applying 3D apparel CAD and new media. To achieve this, three attributes for qualities of effective digital costumes were suggested: faithful reproduction, virtual fabrication, and interactive and stereographic appreciation. Based on these qualities, digital costumes and a PC application were produced and evaluated
OBSERVATION OF THE OVERTONE BAND OF
No full textS. S. Lee, B. F. Ventrudo, D. T. Cassidy, T. Oka, S. Miller, and J. Tennyson, J. Mol. Spec. 145, 222 (1991). D. T. Cassidy, Appl. Opt. 27, 610 (1988). S. Miller and J. Tennyson, private communication.""Author Institution: Department of Chemistry and Department of Astronomy and Astrophysics, The University of Chicago; Department of Engineering Physics, McMaster University; Department of Physics and Astronomy, University College LondonWe report the observation the second overtone of using a 1.45 InGaAsP near infrared diode laser with the short external cavity mode control technique developed at McMaster was generated using 1.5 Torr of with or without Torr of He in a liquid- cooled multiple-inlet-multiple-outlet discharge cell. The signal was detected with velocity modulation or ion concentration modulation in an AC glow discharge. Altogether four lines have been observed in the region of 6860--6925 . The positions of the lines were determined using a wavemeter calibrated with reference lines. The assignment of the transitions is based on Miller and Tennyson’s first principles and on observed temperature dependence of the relative intensities. Extended search of other transitions is being conducted. It is our hope that this observation may lead to detection of in higher vibrational states in Jupiter and other astronomical objects, and that it may also help in the assignment of the laboratory FTIR emission spectrum of hydrogen plasma
Vitamin D supplementation and breast cancer prevention : a systematic review and meta-analysis of randomized clinical trials
No full textIn recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the “Related Article” feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects model. Heterogeneity was assessed using the I2 test. In sensitivity analysis, we assessed the impact of vitamin D dosage and mode of administration on treatment effects. Only two randomized controlled trials fulfilled the pre-set inclusion criteria. The pooled analysis included 5372 postmenopausal women. Overall, Risk Ratios and 95% Confident Intervals were 1.11 and 0.74–1.68. We found no evidence of heterogeneity. Neither vitamin D dosage nor mode of administration significantly affected breast cancer risk. However, treatment efficacy was somewhat greater when vitamin D was administered at the highest dosage and in combination with calcium (Risk Ratio 0.58, 95% Confident Interval 0.23–1.47 and Risk Ratio 0.93, 95% Confident Interval 0.54–1.60, respectively). In conclusions, vitamin D use seems not to be associated with a reduced risk of breast cancer development in postmenopausal women. However, the available evidence is still limited and inadequate to draw firm conclusions. Study protocol code: FARM8L2B5L
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