6,885 research outputs found
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Valvulas MJ enpresaren instalazio elektrikoa
No full textValvulas MJ enpresak fabrika berri bat sortu nahi du, horretarako MJ Instalazioak enpresak instalazio elektriko osoa burutuko du.
Fabrika berria Urdulizen kokaturik egongo da eta tamaina handiko balbulak egingo ditu.
Beste aldetik, instalazio elektrikoa 600 m2-ko gainazala duen fabrika batetan burutuko da, hauetatik 518 m2 erabilgarriak direnak.
Instalazio elektrikoa aurrera eramateko, MJ Instalazioak enpresak transformazio zentro berria diseinatuko du eta behe tentsioko instalazio elektrikoa osorik berrituko du.
Enpresaren behe tentsioko instalazioak elementu hauek izan behar ditu: koadro orokorra, koadro sekundarioa, argiztapenerako zirkuituak, indarren zirkuituak eta makinak.
Honetaz gain, Valvulas MJ enpresak bi programa desberdin eskatu dizkio MJ Instalazioak enpresa proiektugileari. Batak makinara doan korrontea monitorizatuko du, eta besteak eroaleen sekzioa eta babes egokiaren aukeraketa egokia burutzeko erabiliko da.
Makinara doan korrontea monitorizatuko duen programa pilotua berritzailea izango da, modu honetan makinen mantenua burutzerakoan lagungarria izango dena. Aurrerago, programa pilotua garatuz gero, instalazioaren monitorizatzeaz gain, instalazio osoaren kontrola lortu ahal izango da.
Programa burutzeko, Matlabeko GUI erreminta erabiliko da. Interfaze grafiko honen bidez, aurretik aipatu bezala, makina bakoitzera doan korrontea monitorizatuko da.
Eroaleen sekzioa eta babes aproposaren aukeraketa egiteko programa, lagungarria izango da mantentze departamenturako. Kasu honetan, Exceleko VBA programaren bidez burutuko da. Batik bat, arazo baten aurrean babesaren aldaketa egiteko erabiliko duena, edota enpresa handitu nahi izanez gero, makina berriak sartzerakoan, eroale eta babes berriak gehitzerako momentuan hautaketa egokia egiteko erabiliko dena.
Orokorrean, proiektuko atalak hurrengokoak dira:
1) Proiektuaren garapena.
1.1. Transformazio zentroaren kalkulu eta diseinua.
1.2. Barneko argiztapenaren kalkulu eta diseinua.
1.3. Larrialdiko argiztapenaren kalkulu eta diseinua.
1.4. Eroaleen sekzioen kalkulua.
1.5. Babesen kalkulua.
1.6. Lurrera jartzeko kalkuluak.
1.7. Energia erreaktiboaren konpentsazioa.
1.8. Etengabeko elikatze-iturria.
2) Instalazioa monitorizatzeko programa, makina bakoitzera doan korrontea adieraziko duelarik.
3) Eroaleen sekzioa eta bere babeseko elementuak hautatzeko programa.
4) Instalazioaren errealizazioa.La empresa Valvulas MJ quiere crear una nueva fábrica, para ello la empresa MJ Instalazioak realizará toda la instalación eléctrica necesaria.
La fábrica estará situada en Urduliz y tendrá como objetivo fabricar válvulas de gran tamaño.
Por otra parte, la instalación eléctrica se llevará a cabo en una superficie de 600 m2 con 518 m2 útiles.
Para llevar a cabo la instalación eléctrica, la empresa MJ Instalazioak diseñará el centro de transformación y renovará toda la instalación de baja tensión.
La instalación de baja tensión tendrá los siguientes elementos: Un cuadro general, un cuadro secundario, los circuitos de iluminación, el circuito de fuerzas y las maquinas.
Además, la empresa Valvulas MJ ha solicitado el desarrollo de dos programas a la empresa MJ Instalazioak. Un programa consistirá en monitorizar la instalación, monitorizando las corrientes que van a cada máquina. El otro programa, será de gran ayuda a la hora de la elección de secciones de los conductores y los elementos de seguridad correspondientes.
El programa piloto que monitoriza la corriente que va a la máquina, será un programa innovador, de esta manera, cuando se tenga que hacer el mantenimiento de la máquina, será muy útil. Más adelante, si se desarrolla este programa piloto, se podría lograr un control completo de toda la instalación.
Para llevar a cabo el programa, se utilizará la herramienta GUI de Matlab. Mediante esta interface gráfica, se monitorizará la corriente que va a cada máquina.
El programa para la selección de la sección y la protección adecuada de los conductores, será un programa útil para el departamento de mantenimiento. En este caso, para llevar a cabo el programa se ha utilizado VBA de Excel.
Por ejemplo, ante un fallo, se puede utilizar este programa para cambiar la protección correspondiente, o si se desea ampliar la fábrica colocando maquinas nuevas, se usará para tomar la decisión correcta en el momento de agregar nuevos conductores y protecciones.
En general, las partes del proyecto son las siguientes:
1) Desarrollo del proyecto.
1.1. Cálculo y diseño del centro de transformación.
1.2. Cálculo y diseño de la iluminación.
1.3. Cálculo y diseño de la iluminación de emergencia.
1.4. Cálculo de la sección de los conductores.
1.5. Cálculo de las protecciones.
1.6. Cálculos de puesta a tierra.
1.7. Compensación de la energía reactiva.
1.8. Sistema de alimentación ininterrumpida.
2) Programa para monitorizar la instalación, mostrando las corrientes que van a cada máquina.
3) Programa para la elección de los conductores y sus respectivas protecciones.
4) Realización de la instalación.The company Valvulas MJ wants to create a new factory, for this purpose the company MJ Instalazioak will perform all the necessary electrical installation.
The factory will be located in Urduliz and will aim to manufacture large-sized valves.
On the other hand, the electrical installation will take place in an area of 600 m2 with 518 m2 useful area.
To perform the electrical installation, the company MJ Instalazioak will design the transformation center and renew all the low voltage installation.
The low voltage installation will have the following elements: A general box, a secondary box, lighting circuits, the circuit of forces and the machines.
Apart from this, the company valvulas MJ has requested the development of two programs to the company MJ Instalazioak. One of them will consist of monitoring the installation, showing the currents that go to each machine. The other program will be of great help at the time of choosing sections of the wires and the corresponding security elements.
The pilot program that indicates the currents that goes to the machine will be an innovative program, in this way, when you have to do the maintenance of the machine, it will be very useful. Later on, if this pilot program is developed, could be achieved the complete control of the all installation
The Matlab GUI tool will be used to carry out the program. Using this graphical interface, the current that goes to each machine will be monitored.
The program for the selection of the section and the adequate protection of the wires will be a useful program for the maintenance department. In this case, Excel VBA has been used to carry out the program.
For example, after a fault in a wire of the installation, this program will be used to change the corresponding protection or wire, or if you want to increase the factory by entering new machines, it will be used to make the correct decision when adding new wires and their corresponding protections.
In general the parts of the project are the following points:
1) Development of the project.
1.1. Calculation and design of the transformation center.
1.2. Calculation and design of lighting.
1.3. Calculation and design of emergency lighting.
1.4. Calculation of the section of the wires.
1.5. Calculation of the section of the protections.
1.6. Calculation of grounding.
1.7. Compensation of reactive power.
1.8. Uninterruptible power supply.
2) Program to monitor the installation, showing the currents that go to each machine.
3) Program for the choice of wires and their respective protections.
4) Realization of the intallation
Will TV series go the way of Charles Dickens?
No full textWill TV series go the way of Charles Dickens
The SF-36: a simple, effective measure of mobility disability for epidemiological studies
No full textBackgroundMobility disability is a major problem in older people. Numerous scales exist for the measurement of disability but often these do not permit comparisons between study groups. The physical functioning (PF) domain of the established and widely used Short Form-36 (SF-36) questionnaire asks about limitations on ten mobility activities.ObjectivesTo describe prevalence of mobility disability in an elderly population, investigate the validity of the SF-36 PF score as a measure of mobility disability, and to establish age and sex specific norms for the PF score.MethodsWe explored relationships between the SF-36 PF score and objectively measured physical performance variables among 349 men and 280 women, 59-72 years of age, who participated in the Hertfordshire Cohort Study (HCS). Normative data were derived from the Health Survey for England (HSE) 1996.Results32% of men and 46% of women had at least some limitation in PF scale items. Poor SF-36 PF scores (lowest fifth of the gender-specific distribution) were related to: lower grip strength; longer timed-up-and-go, 3m walk, and chair rises test times in men and women; and lower quadriceps peak torque in women but not men. HSE normative data showed that median PF scores declined with increasing age in men and women.ConclusionOur results are consistent with the SF-36 PF score being a valid measure of mobility disability in epidemiological studies. This approach might be a first step towards enabling simple comparisons of prevalence of mobility disability between different studies of older people. The SF-36 PF score could usefully complement existing detailed schemes for classification of disability and it now requires validation against them
Optimized Clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104
No full textWe have previously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered to express the E. coli-derived cytosine deaminase gene are effective in converting systemically injected nontoxic 5-fluorocytosine into the toxic anticancer drug 5-fluorouracil, thereby producing tumor-specific antitumor activity. To improve the expression of E. coli-derived genes with this system, we first replaced the original fdP promoter in the vector with one of two powerful endogenous clostridial promoters: that of the thiolase gene (thlP) and that for the clostridial transcription factor abrB310 (abrBP). These substitutions improved protein expression levels of the prodrug-activating genes by 2- to 3-fold in comparison with fdP-driven expression. However, despite these strong promoters, we found much higher expression of the nitroreductase (NTR) protein in the E. coli host compared with the clostridial host, which we hypothesized could be the result of different codon use between the two organisms. To test this, we constructed new expression vectors with an artificially synthesized NTR gene using optimized clostridial codons (sNTR). Results from both enzymatic assays and Western blots of cell extracts from clostridial transformants harboring plasmid constructs of thlP-sNTR and abrBP-sNTR showed that the expression and activity of the NTR gene product was increased by similar to 20-fold compared with the original construct. In vivo studies with i.v. administered sNTR-expressing C. sporogenes spores in SiHa tumor-bearing mice showed significantly improved antitumor efficacy when combined with either 5-aziridinyl-2,4-dinitrobenzamide (CB1954) or the novel dinitrobenzamide mustard prodrug, PR-104.X113235sciescopu
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Table S4. GO enrichment analysis for the target genes of temporally differentially expressed phosphoproteins in MJ
No full textGO enrichment analysis for the target genes of temporally differentially expressed phosphoproteins in M
Indices de erosividade das chuvas da regiao de Goiânia, GO
No full textThe measure of rainfall erosive potential is becoming object of many studies, since this parameter is indispensable in the studies of models for the prediction of soil losses through hydrical erosion. This study was carried out at EMGOPA/Embrapa-CNPS experimental station, to determine the rainfall erosivity for the Goiania region, GO, Brazil, through rainfall graphical data. The rainfall annual average erosivity for the region was 8353.0 MJ mm/ha/year and 129.8 MJ/ha/year, respectively for EI30 and KE > 25. The correlation coefficients showed that the rainfall and rainfall coefficient allow to estimate the rainfall erosivity in the absence of more complete rainfall data. The erosion critical period, due to the occurrence of erosive rainfalls is from September to February, when 85.70% and 84.05% of the KE > 25 and EI30 annual total, respectively, occurr. In this period, conservation practices are necessary in order to reduce the hydrical erosion, for the maintenance of soil sustainability. (Résumé d'auteur
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
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