3,417 research outputs found
Analysis of GWAS top hits in ADHD suggests association to two polymorphisms located in genes expressed in the cerebellum
No full textAttention deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder influenced by genetic factors. Several chromosomal regions with potential linkage and candidate genes associations have been reported, but findings are often inconsistent and non-replicated. The few genome-wide association studies (GWAS) carried out so far differ for study design and phenotypes analyzed, and did not detect any association significant at the genome-wide level. In the present study we examined the top SNPs reported in the GWAS by Neale et al. [2008] in an independent cohort. Although our sample size is smaller (415 trios vs. 909), the power was sufficient to confirm the role of candidate markers in ADHD if a true association exists. Two out of 36 top SNPs were significant at alpha = 0.05 in our sample, although none was still significant after correction for multiple tests. These two SNPs are both located in genes coding for as yet uncharacterized proteins expressed in the cerebellum, XKR4 in 8q12.1, and FAM190A in 4q22.1. Three other FAM190A SNPs have TDT P-values of <10(-5) in our sample, a level of significance only reached by a total of five SNPs in our genome-wide data. While these findings could be due to chance, we cannot exclude that these markers are indeed associated to disease risk. Remarkably, brain imaging studies have shown reduction of the posterior inferior cerebellar lobules volume of ADHD boys and girls compared to controls, persistent with age and not present in unaffected siblings, suggesting that the cerebellum may be directly related to pathophysiology of ADHD. (C) 2010 Wiley-Liss, Inc
Joseph E. Lowery Speaking to E. Randel T. Osburn, April 1986
No full textJoseph E. Lowery is shown speaking to E. Randel T. Osburn alongside Evelyn G. Lowery and others at a Southern Christian Leadership Conference Board Luncheon. Written on verso: Discussing a "serious problem"... President Lowery instructs E. Randel T. Osburn and Sevell Brown, III to improvise as SCLC is confronted with larger turnout for board luncheon than anticipated. Awaiting lunch is Mrs. Lowery, Dr. David Swenton, speaker and Rev. Emmanuel Cleaver.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Joseph & Evelyn Lowery Institute for Justice and Human Rights, the Joseph Echols Lowery Irrevocable Trust, and other donors in supporting the processing and digitization of Morehouse College's Joseph Echols and Evelyn Gibson Lowery Collection
[Letter from Joseph C. Keeley to T. N. Carswell - July 9, 1956]
No full textA letter written to Mr. T. N. Carswell, Abilene, Texas, from Joseph C. Keeley, Editor, The American Legion Magazine, New York, New York, dated July 9, 1956. Keeley replies to Carswell's request for a copy of an article by forwarding his letter to Merle Sinclair, the author
Supporting disabled children and their families in Scotland: A review of policy and research
No full textThe Joseph Rowntree Foundation has been supporting research about disabled children and their families for a number of years. An earlier Foundations covering the messages from these projects has already been published (1). This Foundations places the messages from that work into the Scottish context. It gives an overview of current policies affecting disabled children and their families in Scotland and draws on research carried out north of the border
Letter from Carl Hayden to Joseph J. Cotter
No full textLetter from Carl Hayden to Joseph J. Cotter regarding suggestions on the proposed national park bill
Letter from Joseph J. Cotter to Carl Hayden
No full textLetter from Joseph J. Cotter to Carl Hayden regarding the use of water power and summer homes in the proposed park boundaries
Letter from Joseph J. Cotter, U.S. National Park Service, to Representative Hayden
No full textLetter from Joseph J. Cotter to Carl Hayden detailing the approximate amount of patented land within the proposed borders of the national park. Thomas J. Croaff is mentioned in his belief that he owns half the land in the proposed area; however, Joseph J. Cotter disputes this claim. Ralph Cameron's mining interests in the park are also mentioned. Circa 1917
"The City, the Country, and the Road Between": The 2011 Lion and the Unicorn Award for Excellence in North American Poetry.
No full textPeer reviewe
Joseph and Evelyn Lowery With Others, 1984
No full textJoseph and Evelyn Lowery stand with others in the SCLC headquarter's conference room, including E. Randel T. Osburn (next to Joseph Lowery), Rosario Murillo de Ortega, and Jean Young (at far right). Ortega was visiting Atlanta with her husband Daniel Ortega, the Sandinista leader in Nicaragua. For more information about the Ortegas' visit to Atlanta, see pages 34-37 in the December-January 1984-1985 SCLC Magazine issue: http://hdl.handle.net/20.500.12322/auc.199:07388.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Joseph & Evelyn Lowery Institute for Justice and Human Rights, the Joseph Echols Lowery Irrevocable Trust, and other donors in supporting the processing and digitization of Morehouse College's Joseph Echols and Evelyn Gibson Lowery Collection
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