1,996 research outputs found
Design of a new Faculty of Architecture - Investigation and design of Media Facades
No full textGraduation Project [G.J. Smit] for both Architecture & Building Technology. [architecture] : design of a new Faculty of Architecture [building technology] : investigation and design of Media FacadesStrategic Architectural Design DevelopmentArchitecture & Building TechnologyArchitectur
Watertovenaars: Delftse ideeën voor nog 200 jaar Rijkswaterstaat
No full textEen bundel artikelen met inspiratie voor Rijkswaterstaat voor de ontwikkeling in de volgende 200 jaar. Watertovenaar of tovenaarsleerling? (K. d'Angremond, P. Huisman en G.I. Schiereek) De oudste deltawerken: dammen en duikers uit het begin van de jaartelling (T. de Ridder) Een erfenis uit de Bataafse periode (W.M. de Jong) Wat eerst: wonen, water, wegen of welvaart? (T.M. de Jong) Een nieuwe rol voor de waterstaatsingenieur (F.M. Sanders) De terugkeer van de stedenbouwkundige discipline (V.J. Meyer Water (P. Huisman, K. d'Angremond en G.J. Schiereek) Dynamische buffers in autosnelwegen (D. Westland en P.H.L. Bovy) Op de automatische piloot door de Randstad? (R. van der Heijden, V. Marchau, E. Molin en K. van Wees) Niet bruggen bouwen, maar zelf brug zijn (B. Enserink, M.P.M. van der Ploeg, WAH. Thissen en G.J. de Vreede) Nederland als vervoersemplacement? (M.P.C. Weijnen, W.A.H. Thissen en E.F. ten Heuvelhof) Immobilisatie van gevaarlijk afval (Ch.F.Hendriks) Dubbel verduurzamen van wegconstructies (A.A.A. Molenaar) Innovatie van de geometrische infrastructuur (P.J.G.Teunissen) Radarhoogtemetingen en de (voorname) rol van Delft (M. Naeije) Een hoog(water)standje (T. Rientjes, C. van den Akker en P. van der Veer) Naar één beslismodel voor de veiligheid (J.K. Vrijling en J. Stoop) De betrouwbaarheid van dijken (A. Verruijt) Windgolven, een fascinerend fenomeen (L.H. Holthuijsen en J.A. Battjes) Mijn droom: het railvaartuig (B. Boon) Een waterfilm in plaats van wielen (A. van Beek) Uren worden minuten (E.A.H. Vollebregt, H. Jansen en M.R.T. Roest) Een kwestie van schuiven (R.Brouwer, A.Hof en J. Schuurmans) Energie door vergisting van slib (M.S.M. letten en M.C.M. van Loosdrecht) Nóg een poldermodel: hoge-sterkte beton (J.C. Walraven) Atollen voor de Noordzeekust (J. Kristinsson) Van maker naar regisseur (H.A.J. de Ridder
Sustainable Chemical Processes and Products. New Design Methodology and Design Tools
No full textThe current chemical industry is not sustainable, which leads to the fact that innovation of chemical processes and products is too often hazardous for society in general and the environment in particular. It really is a challenge to implement sustainability considerations in the design activities of chemical engineers. Therefore, the main question of this thesis is: how can a trained chemical engineer develop a conceptual design of a chemical process or a chemical product in such a way that the final result clearly contributes to sustainable development? This question is answered after a profound discussion about the current chemical engineering practice and its relation to the sustainability debate. This dissertation claims that sustainable development of chemical engineering practices requires a general design methodology accompanied by a set of design tools. Such a combination of methodology and tools does not exist in the chemical engineering field. The author developed a new design methodology and seven new design tools that enable the incorporation of sustainability issues into the design practice of the chemical engineering field. The application and validity of the methodology and its tools are shown in seven, mainly industrial, case studies.Applied Science
The role of eosinophil major basic protein in angiogenesis
No full textBACKGROUND: Eosinophil-derived major basic protein (MBP) plays an active role in allergic inflammation and tissue remodelling. However, its role in angiogenesis has not been established as yet. Therefore our objective was to investigate whether MBP exhibits any direct pro-angiogenic effects. METHODS: Rat aortic endothelial cells and human umbilical vascular endothelial cells were cultured with different concentrations of MBP and their viability (Trypan blue exclusion test), proliferation (thymidine incorporation) and capillary-like structure formation (matrigel assay) were investigated in vitro. The angiogenic activity of MBP was then tested in vivo using the chick chorio allantoic membrane (CAM) assay. RESULTS: Subcytotoxic concentrations of MBP induce endothelial cell proliferation and enhance the pro-mitogenic effect of vascular endothelial growth factor (VEGF), but do not affect their VEGF release. MBP promotes capillarogenesis by endothelial cells seeded on matrigel and sprouting formation in the CAM assay. Furthermore, we have shown that the pro-angiogenic effect of MBP is not due to its cationic charge since stimulation of the CAMs with the synthetic polycation, poly-L-arginine does not induce any angiogenic effects. CONCLUSIONS: These data demonstrate that MBP has pro-angiogenic effects in vitro and in vivo, providing a novel mechanism whereby MBP can participate in tissue inflammation and remodelling in atopic diseases
Eosinophil-derived neurotoxin and human liver ribonuclease. Identity of structure and linkage of neurotoxicity to nuclease activity.
No full textEosinophil-derived neurotoxin and human liver ribonuclease. Identity of structure and linkage of neurotoxicity to nuclease activity.
No full textAuthor response
No full textMost motile bacteria sense and respond to their environment through a transmembrane chemoreceptor array whose structure and function have been well-studied, but many species also contain an additional cluster of chemoreceptors in their cytoplasm. Although the cytoplasmic cluster is essential for normal chemotaxis in some organisms, its structure and function remain unknown. Here we use electron cryotomography to image the cytoplasmic chemoreceptor
cluster in Rhodobacter sphaeroides and Vibrio cholerae. We show that just like transmembrane arrays, cytoplasmic clusters contain trimers-of-receptor-dimers organized in 12-nm hexagonal arrays. In contrast to transmembrane arrays, however, cytoplasmic clusters comprise two CheA/
CheW baseplates sandwiching two opposed receptor arrays. We further show that cytoplasmic fragments of normally transmembrane E. coli chemoreceptors form similar sandwiched structures in the presence of molecular crowding agents. Together these results suggest that the 12-nm
hexagonal architecture is fundamentally important and that sandwiching and crowding can replace the stabilizing effect of the membrane
Verslag omtrent den aanleg van stroomleidende dammen in de Zandkreek en Veergat: opgemaakt door den ingenieur van den Rjjksvvaterstaat G.J. van den Broek
No full textOnderzoek naar kribben om de erosie van de steile oevers van het Veerse gat en Zandkreek tegen te gaa
Verslag omtrent het gebruik van Indische en Australische houtsoorten, volgens door den Rijkswaterstaat verstrekte gegevens, bewerkt door den ingenieur van den Rijkswaterstaat G.J. van den Broek
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