1,720,999 research outputs found
Analisi in vivo e in vitro dell’attività del doppio carbapenemico nelle infezioni da Klebsiella pneumoniae produttrice di carbapenemasi
Full text linkNegli ultimi anni si è assistito ad un incremento delle Enterobacteriaceae che producono carbapenemasi (CPE) in tutto il mondo; in Italia nell'ultima decade si è osservato un trend in drammatico aumento dei ceppi di Klebsiella pneumoniae resistente ai carbapenemi (CR-Kp).
La presente tesi dimostra l’efficacia in vivo e l’attività in vitro della terapia con il doppio carbapenemico (meropenem + ertapenem) nei pazienti con infezione da Klebsiella pneumoniae produttrice di carbapenemasi, nei quali l’utilizzo della colistina era controindicato per tossicità o resistenza. I dati clinici sono stati supportati dalle analisi in vitro, che hanno evidenziato come questa associazione risulti sinergica e battericida. Siamo inoltre stati in grado di dimostrare che il regime con doppio carbapenemico associato alla colistina risulta efficace anche a concentrazioni sub-inibitorie dei farmaci. Il doppio carbapenemico da solo può essere una valida opzione terapeutica nei casi in cui la colistina risulta poco indicata, mentre la combinazione meropenem + ertapenem + colistina può essere particolarmente utile nei soggetti in condizioni cliniche gravi, quando una precoce risposta clinica è fondamentale.
Il nostro case report dimostra invece l’efficacia della terapia con doppio carbapenemico in una paziente sottoposta a trapianto renale e con una grave infezione batteriemica da Escherichia coli produttrice di carbapenemasi. Questo approccio non convenzionale potrebbe essere considerato come terapia di salvataggio in quei soggetti in cui altre combinazioni antibiotiche falliscono o quando si preferisce non utilizzare la colistina. Infine questo caso evidenzia che fare test di sinergia in vitro rappresenta un’utile strategia per selezionare la migliore combinazione antibiotica, specialmente nei casi di infezioni in individui ad alto rischio come i soggetti trapiantati
FIGURE 5 in Planktonic Ctenophora of the Madeira Archipelago (Northeastern Atlantic)
No full textFIGURE 5. World distribution of (A) E.vexilligera, (B) O. crystallina, and (C) C. veneris. Red triangle: present records in Madeira ArchipelagoPublished as part of Gueroun, Sonia Km, Schäfer, Susanne, Gizzi, Francesca, Álvarez, Soledad, Monteiro, João Gama, Andrade, Carlos & Canning-Clode, João, 2021, Planktonic Ctenophora of the Madeira Archipelago (Northeastern Atlantic), pp. 433-443 in Zootaxa 5081 (3) on page 439, DOI: 10.11646/zootaxa.5081.3.7, http://zenodo.org/record/577586
Cestum veneris Lesueur 1813
No full textCestum veneris Lesueur, 1813 (Table 1, Fig. 4A) Synonymes: Cestus pectinalis Bigelow, 1904; Cestus veneris Chun, 1879 Examined material: Southeast Porto Santo Island, 33°03’05”N 16°20’09”W. One specimen was observed at 12 m depth, near the sand floor, during a SCUBA dive. Description: Body laterally expanded and flattened, long and ribbon-like, around 1 m in width, transparent. Presence of purplish-black pigment on its wingtips (brown-yellowish colour on the video record due to the light spectrum gradient) (Fig. 4A 2). Remark: While no individual was clearly photographed, some reports indicate C. veneris occurrence in the southern part of the Madeira Island (Peter Wirtz pers. comm).Published as part of Gueroun, Sonia Km, Schäfer, Susanne, Gizzi, Francesca, Álvarez, Soledad, Monteiro, João Gama, Andrade, Carlos & Canning-Clode, João, 2021, Planktonic Ctenophora of the Madeira Archipelago (Northeastern Atlantic), pp. 433-443 in Zootaxa 5081 (3) on page 438, DOI: 10.11646/zootaxa.5081.3.7, http://zenodo.org/record/577586
Ocyropsis crystallina Rang 1827
No full textOcyropsis crystallina Rang, 1827 (Table 1, Fig. 3) Synonym: Ocyroe crystallina Rang, 1827 Examined material: East coast of Ilhéu da Cal, Porto Santo Island, 33°00’19”N 16°22’13”W. Two individuals were observed during SCUBA diving; one specimen was collected between 2 and 6 m depth. Description: Body laterally compressed with two large flapping oral lobes. The auricles are flat and ribbonlike; their narrow edges are lined with long cilia. The stomodaeum is flat, with broadsides constricted near the middle (Fig. 3).Published as part of Gueroun, Sonia Km, Schäfer, Susanne, Gizzi, Francesca, Álvarez, Soledad, Monteiro, João Gama, Andrade, Carlos & Canning-Clode, João, 2021, Planktonic Ctenophora of the Madeira Archipelago (Northeastern Atlantic), pp. 433-443 in Zootaxa 5081 (3) on pages 436-437, DOI: 10.11646/zootaxa.5081.3.7, http://zenodo.org/record/577586
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Eurhamphaea vexilligera Gegenbaur 1856
No full textEurhamphaea vexilligera Gegenbaur, 1856 (Table 1, Fig. 2) Synonym: Mnemia elegans M. Sars, 1856 Examined material: East coast of Ilhéu da Cal, Porto Santo Island, 33°00’18”N 16°22’13”W and 33°00’19”N 16°22’13.08”W. Several adults were observed during SCUBA diving, and two individuals were collected between 2 and 6 m depth. In Porto Santo harbour (33°3’45”N 16°18’59”W), one specimen was collected at the sea surface (0.5 m depth). Description: Overall, body length of the sampled specimens varied from three to six cm. The biggest specimen, around 10 cm, was observed in situ (West coast of Ilhéu da Cal, 33°00’13”N 16°23’34”W). The body was elongated, narrow with a noticeable compression in the tentacular axis (Fig. 2A). Two horn-shaped processes terminating in the long flexible filament are drawn out at the aboral apex (Fig. 2B). Subtentacular ctene rows extend onto these processes. Reddish-brown ink vesicles with bioluminescent properties follow the path of the substomodeal meridional canals (Fig. 2C).Published as part of Gueroun, Sonia Km, Schäfer, Susanne, Gizzi, Francesca, Álvarez, Soledad, Monteiro, João Gama, Andrade, Carlos & Canning-Clode, João, 2021, Planktonic Ctenophora of the Madeira Archipelago (Northeastern Atlantic), pp. 433-443 in Zootaxa 5081 (3) on pages 435-436, DOI: 10.11646/zootaxa.5081.3.7, http://zenodo.org/record/577586
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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