1,720,966 research outputs found
Recombinant interferon α-2b in the treatment of genital herpes: Clinical and laboratory rationale and efficacy evaluation
No full textAccording to the World Health Organization, a significant part of the population is susceptible to diseases caused by herpes viruses, among which genital herpes occupies a leading position in the incidence and severity of clinical manifestations. A promising strategy for the treatment of herpesvirus infections caused by herpes simplex virus (HSV) types 1 and 2 is the use of recombinant interferon-α preparations. Objective. To conduct a comparative analysis of the efficacy of using recombinant interferon α-2b with an active substance content of 1.000.000 IU and 3.000.000 IU in the treatment of genital herpesvirus infection. Patients and methods. A retrospective study of 100 patients with recurrent genital herpes 5.5±1.25 per year at the age from 20 to 52 was carried out. The diagnosis was made based on complaints, clinical examination results and laboratory parameters. The presence of herpes virus antigen in the sample material, clinical status, clinical and biochemical parameters of peripheral blood, and the activity of antioxidant enzymes were assessed. Results. The maximum efficacy of therapy for genital herpesvirus infection was registered in patients who received complex treatment with valacyclovir and recombinant interferon α-2b with antioxidants at a dosage of 3.000.000 IU. © 2021, Dynasty Publishing House. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
АНАЛИЗ АНТИОКСИДАНТНЫХ ЭФФЕКТОВ КУРКУМИНА ИЗ КОРНЕВИЩ РАСТЕНИЯ КУРКУМЫ ДЛИННОЙ (CURCUMA LONGA) С ЦЕЛЬЮ СОЗДАНИЯ ФАРМАЦЕВТИЧЕСКОЙ КОМПОЗИЦИИ ДЛЯ КОРРЕКЦИИ ОКСИДАТИВНЫХ НАРУШЕНИЙ
No full textAnalysis of modern data on the role of turmeric (Curcuma longa), one of the components of the extract of rhizomes of turmeric longa (Curcuma longa), in the correction of oxidative stress was carried out
Biopharmaceutical trials of a dosage form, which contain methionine and turmeric extract (Curcuma longa l.)
No full textIntroduction. The presence of biologically active substances in the extract from the roots of turmeric extract (Curcuma longa L.) makes it reasonable and makes it possible to predict their effectiveness in pathological conditions caused by oxidative stress and immune disorders arising against its background. Based on data obtained, a pattern was revealed in improving the solubility of the combination of methionine and turmeric extract, which includes auxiliary substances. Dosage form – granules with methionine and liquid turmeric extract, with enteric coat can be used to eliminate the consequences of oxidative and immune disorders, treatment and prevention of systemic diseases caused by oxidative stress. Aim. Biopharmaceutical and in-process tests of the pharmaceutical composition of granules with methionine and liquid turmeric extract. Materials and methods. The object of the trials was the multicomponent drug containing methionine and a liquid turmeric extract of the roots. The proposed composition of plant compositions is original, had no analogues and protected by a patent for an invention (RU 268 4111). To assess the pharmaceutical properties, biopharmaceutical trials carried out by the UV-spectrophotometric method using biorelevant medium. The research results statistically processed using Statistica for Windows, version 10. Results and discussion. Based on the data obtained, a pattern revealed in improving the solubility of the combination of methionine and turmeric extract, in contrast to the multicomponent composition containing only turmeric extract. Conclusion. The developed multicomponent pharmaceutical composition will expand the register of herbal medicines of domestic production for the prevention and treatment of diseases caused by oxidative stress. © Gizinger O. A., Khisamova A. A., 2021
АНАЛИЗ ДАННЫХ АНАМНЕЗА И КЛИНИЧЕСКИХ ПОКАЗАТЕЛЕЙ СОСТОЯНИЯ ДЕТЕЙ С ХРОНИЧЕСКИМ АДЕНОИДИТОМ, ПРОЖИВАЮЩИХ В ГОРОДЕ ЧЕЛЯБИНСКЕ И ЧЕЛЯБИНСКОЙ ОБЛАСТИ
No full textWe studied the clinical and anamnestic features of children with chronic adenoiditis living in the city of Chelyabinsk and the Chelyabinsk region and compare the data with the performance of children without chronic adenoiditis. A prospective analysis of anamnestic data of children aged 4-8 years with chronic adenoiditis was carried out. 55 children without clinical signs of chronic adenoiditis made up the control group and did not have complaints and the clinical picture of the disease at the time of treatment. Analysis of anamnestic data showed a high incidence of infectious and inflammatory diseases, the use of antimicrobial drugs in mothers during pregnancy, and gestational complications in comparison with mothers of healthy children.Изучены клинические и анамнестические особенности детей с хроническим аденоидитом, проживающих в городе Челябинске и Челябинской области и сопоставить полученные данные с показателями детей без хронического аденоидита. Проведен проспективный анализ анамнестических данных детей в возрасте 4-8 лет с хроническим аденоидитом. 55 детей без клинических признаков хронического аденоидита составили группу контроля и не имели на момент обращения жалоб и клинической картины заболевания. Анализ анамнестических данных показал большую частоту инфекционно-воспалительных заболеваний, приема антимикробных препаратов у матерей во время беременности, осложнений гестационного периода у по сравнению с показателями матерей здоровых детей
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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