1,721,286 research outputs found
Recensione di I. Daidone, Giancarlo De Carlo. Gli editoriali di Spazio e Società
No full textIl libro racconta una “storia” che cerca di far comprendere l’importanza e l’attualità dell’architettura sociale, ovvero il riesame della contraddittoria questione fra spazio e società. L’attualità del pensiero di Giancarlo De Carlo, attraverso un’attenta rilettura degli editoriali – raccolti e ripubblicati per la prima volta. Il saggio di Isabella Daidone ripercorre l’esperienza editoriale della rivista «Spazio e Società» con una ricognizione mirata, una narrazione ricomposta che svela la trama di relazioni tra la rivista e il contesto storico degli avvenimenti. Il libro è una riflessione divisa in parti che, come in un racconto rizomatico – un concetto tratto dalla biologia, metafora del descrivere per nodi e diramazioni – serve per dialogare con il lettore mettendo in risalto luoghi, città e territori. Nei brani che l’autrice riporta è la centralità dello spazio fisico a suggerire uno specifico modo di guardare, senza tempo, il reale che ci circonda. Presentazione di Giuseppe Imbesi, Postfazione Marcello Panzarella. Parte del contenuto dell’articolo è stato pubblicato nella rivista «U+D urbanform and design», n. 14, dicembre 2020. La presente stesura, integrata da scritti inediti, costituisce il tentativo di sistematizzazione e sintesi di tematiche costantemente esplorate.The book tells a “story” that seeks to make people understand the importance and relevance of social architecture, or the re-examination of the contradictory question between space and society. The topicality of Giancarlo De Carlo’s thought, through a careful rereading of the editorials - collected and republished for the first time. Isabella Daidone’s essay retraces the editorial experience of the magazine “Space and Society” with a targeted survey, a recomposed narrative that reveals the web of relations between the magazine and the historical context of the events. The book is a reflection divided into parts which, as in a “rhizomatic” tale - a concept taken from biology, a metaphor for describing by nodes and branches - serves to dialogue with the reader, highlighting places, cities and territories. In the passages that the author reports, it is the centrality of physical space that suggests a specific way of looking, without time, at the real that surrounds us. Presentation by Giuseppe Imbesi, Afterword Marcello Panzarella. Part of the content of the article was published in the magazine “U + D urbanform and design”, n. 14, December 2020. This draft, supplemented by unpublished writings, constitutes an attempt to systematize and synthesize constantly explored themes
Recensione di Giancarlo De Carlo. Gli editoriali di Spazio e Società
No full textA due domande di Giancarlo De Carlo - “Forse l’architettura continuerà a esistere, perché dopotutto non se ne può fare a meno. Ma al di qua del suo “fine essenziale”? nella banalità del consumo a-spaziale e a-temporale” - sembra rispondere il saggio di Isabella Daidone, che ripercorrendo l’esperienza editoriale della rivista «Spazio e Società» e mette in moto un processo d’analogia e d’identificazione, nonché d’apprendimento e d’elaborazione, che influenza positivamente l’inconscio del lettore attraverso molte suggestioni. Si tratta di una ricognizione mirata, una narrazione ricomposta che svela la trama di relazioni tra la rivista e il contesto storico degli avvenimenti. Il libro è una riflessione divisa in parti che serve per dialogare con il lettore mettendo in risalto luoghi, città e territori. Pubblicato nella Collana “Città, territorio, piano” diretta da Giuseppe Imbesi n.55 ha in appendice tutti gli editoriali della rivista diretta da De Carlo. Postfazione Marcello Panzarella.Two questions from Giancarlo De Carlo - "Perhaps architecture will continue to exist, because after all it cannot be done without. But on this side of its "essential purpose"? in the banality of a-spatial and a-temporal consumption "- the essay by Isabella Daidone seems to answer, retracing the editorial experience of the magazine" Space and Society "and sets in motion a process of analogy and identification, as well as learning and processing, which positively influences the reader's unconscious through many suggestions. It is a focused reconnaissance, a recomposed narration that reveals the web of relations between the magazine and the historical context of the events. The book is a reflection divided into parts that serves to dialogue with the reader, highlighting places, cities and territories. Published in the “City, territory, plan” series directed by Giuseppe Imbesi n.55, it has in appendix all the editorials of the magazine directed by De Carlo. Afterword Marcello Panzarella
Decoding human cancer with whole genome sequencing: a review of PCAWG Project studies published in February 2020
Full text linkCancer is underlined by genetic changes. In an unprecedented international effort, the Pan-Cancer Analysis of Whole Genomes (PCAWG) of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) sequenced the tumors of over two thousand five hundred patients across 38 different cancer types, as well as the corresponding healthy tissue, with the aim of identifying genome-wide mutations exclusively found in cancer and uncovering new genetic changes that drive tumor formation. What set this project apart from earlier efforts is the use of whole genome sequencing (WGS) that enabled to explore alterations beyond the coding DNA, into cancer’s non-coding genome. WGS of the entire cohort allowed to tease apart driving mutations that initiate and support carcinogenesis from passenger mutations that do not play an overt role in the disease. At least one causative mutation was found in 95% of all cancers, with many tumors showing an average of 5 driver mutations. The PCAWG Project also assessed the transcriptional output altered in cancer and rebuilt the evolutionary history of each tumor showing that initial driver mutations can occur years if not decades prior to a diagnosis. Here, I provide a concise review of the Pan-Cancer Project papers published on February 2020, along with key computational tools and the digital framework generated as part of the project. This represents an historic effort by hundreds of international collaborators, which provides a comprehensive understanding of cancer genetics, with publicly available data and resources representing a treasure trove of information to advance cancer research for years to come
Calcareous Nannofossil paleoecology in the Sapropel S1 of the Eastern Ionian Sea: paleoceanographic implications.
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DNA damage signaling in response to double-strand breaks during mitosis
Full text linkThe signaling cascade initiated in response to DNA double-strandx breaks (DSBs) has been extensively investigated in interphase cells. Here, we show that mitotic cells treated with DSB-inducing agents activate a "primary" DNA damage response (DDR) comprised of early signaling events, including activation of the protein kinases ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK), histone H2AX phosphorylation together with recruitment of mediator of DNA damage checkpoint 1 (MDC1), and the Mre11-Rad50-Nbs1 (MRN) complex to damage sites. However, mitotic cells display no detectable recruitment of the E3 ubiquitin ligases RNF8 and RNF168, or accumulation of 53BP1 and BRCA1, at DSB sites. Accordingly, we found that DNA-damage signaling is attenuated in mitotic cells, with full DDR activation only ensuing when a DSB-containing mitotic cell enters G1. Finally, we present data suggesting that induction of a primary DDR in mitosis is important because transient inactivation of ATM and DNA-PK renders mitotic cells hypersensitive to DSB-inducing agents. © 2009 Giunta et al
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Are productivity and stratification important to sapropel deposition? Microfossil evidence from late Pliocene i-cycle 180 at Vrica, Calabria
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