1,721,000 research outputs found
Aircraft planar trajectories in crosswind navigation: some hypergeometric solutions
No full textWe study the planar motion of a self-propelled object against a withstanding flow, such as wind or sea current, whose speed is capable of perturbing the trajectory of the object, heading it off its path. Seven cases are dealt with, corresponding to fairly general wind types and all leading to nonlinear ordinary differential equations for the object motion. The first two cases concern motions described in Cartesian coordinates. They are followed by motions under a cyclonic wind, analysed in a polar reference frame; the wind is modelled as a logarithmic or hyperbolic spiral and closed-form solutions are obtained by means of the Gauss hypergeometric function and the Lerch transcendent. Further wind instances, treated in a Cartesian or in a polar reference system, require some special functions, such as the Lambert function, while finding the motion time law leads to a trinomial equation, in the most interesting situation of a mobile object that is faster than the wind. In the last case of a horizontal hyperbolic wind, time law and trajectory are computed in a polar reference frame by means of the Lambert function
Molecular and Mathematical Biology, Chemistry, Medicine and Medical Statistics, Bioinformatics and Numerical Analysis (Series in Applied Sciences, vol. 2)
No full text
RADIONUCLIDES FOR BIOMEDICAL USES: AN APPLICATION PROPOSAL WITH 64Cu
No full textIn this proposal has been developed a prototype of radiopharmaceutical
based on the radioactive isotope 64Cu, designed for
theranostic applications in medical field. This radiopharmaceutical was
designed analysing previous results and considering the fundamental
characteristics that it must has.
A radiopharmaceutical based on 64Cu, since is consisting of this radionuclide,
could be used in a diagnostic field (PET and SPECT):
that because the radioisotope copper-64 shows medium-long half
life (12,7 h), interesting decay (β+ and β− emitter) without abundant
gamma emission and it can be produced quickly in large quantities.
After the radiopharmaceutical administration, the radioisotope will
emit radiations that will be taken over by special tools named tomographers
and elaborated to obtain an image of the organism spacetime
distribution of the radiolabelled substance; in addition, the
emitting particles could be of aid in therapy when the radioisotope is
opportunely distributed
A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland
Full text linkWe recently designed an innovative scaffold-bioreactor unit for the bioengineering of a three-dimensional (3D) bioartificial human thyroid gland or its miniaturized replica as a part of a microfluidic chip test system.This device is based on the evidence that the 3D geometry of the intraglandular stromal/vascular scaffold (SVS; i.e., the fibrous and vascular matrix) of mammalian viscera plays a key role in guiding growth and differentiation of in vitro seeded cells. Therefore, we initiated a research program focused on computer-aided reconstruction of the 2nd to 4th order intralobar arterial network (IAN) of the human thyroid gland asa reliable surrogate for its 3D SVS, to be used as an input for rapid prototyping of a biomaterial replica. Tothis end, we developed a computational template that works within the Mathematica environment, giving rise to a quasi-fractal growth of the IAN distribution, constrained within an approximation of the thyroidl obe shape as a closed surface. Starting from edge detection of planar images of real human thyroid lobes acquired by in vivo real-time ultrasonography, we performed data approximation of the lobar profiles based on splines and Bezier curves, providing 3D lobar shapes as geometric boundaries for vessel growth by a diffusion-limited aggregation model. Our numerical procedures allowed for a robust connection between development of lobar arterial trees and thyroid lobe shape, led to a vascular self-similarity consistent with that of a cadaveric lobar arterial cast, and reproduced arterial vessels in a proportion not statistically different from that described for the real human thyroid gland. We conclude that our algorithmic template offers a reliable reproduction of the extremely complex IAN of the adult human thyroid lobe, potentially useful as a computational guidance for bioprinting of thyroid lobe matrix replicas. In addition, due to the simplicity and limited number of morphometrical parameters required by our system, we predict its application to the design of a number of patient-tailored human bioartificial organs and organs-on-chip,including parenchymal viscera and bones
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Mathematics and Computers in Simulation
No full textThe aim of the journal is to provide an international forum for the dissemination of up-to-date information in the fields of the mathematics and computers, in particular (but not exclusively) as they apply to the dynamics of systems, their simulation and scientific computation in general.
Mathematics and Computers in Simulation, published monthly, is the official organ of IMACS, the International Association for Mathematics and Computers in Simulation
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