70 research outputs found
Grgur Garbin († 1621), captain of artillerymen, and his house in Zadar
No full textU radu se na temelju arhivskih i terenskih istraživanja donose nove spoznaje o luneti portala s nekadašnje kuće obitelji Garbin u Zadru, danas ugrađenoj u kuću u Ulici Mate Karamana. Preciznije se blazonira grb u luneti portala te ga se dovodi u vezu s kapetanom zadarskih topnika Grgurom Garbinom. Plemićka obitelj Garbin podrijetlom je iz Paga, a jedna grana prešla je početkom 17. stoljeća u Zadar. Zaključuje se da je luneta portala izrađena malo nakon 1609. godine kada prema arhivskim dokumentima Grgur Garbin kupuje kuću u blizini samostana sv. Dimitrija u Zadru. Utvrđuje se položaj kuće te se donose novi arhivski podatci iz života Grgura Garbina i njegovih potomaka. Saznaje se da je njegov sin Ivan Grgur (Zan Gregorio) zanimanjem bio zlatar.On the basis of the conducted archival and field research, the author presents new knowledge regarding the portal lunette earlier home of the Garbin family in Zadar, today built into the front facade of the house in Mate Karaman Street. The author describes the coat of arms in the portal lunette, and consequently – since it shows a cannon and a male head with the characteristic hat – brings it into connection with Grgur Garbin, captain of the Zadar artillerymen. In the 17th century, this type of hat – decorated with long feathers and identical to the one on Garbin’s grave – made an integral part of the uniform of Venetian commanders holding the rank of captain; this counts for artillery units, too. The noble Garbin family originates from the island of Pag, and one family branch moved to Zadar at the beginning of the 17th century. It is concluded that the portal lunette was built just after the year 1609, when – according to the archival documents – Grgur Garbin had bought a house near the monastery of St. Demetrius in Zadar. The author sets the accurate location of Garbin’s house and brings fresh archival data from the life of Grgur Garbin and his descendants. Record on the death of Grgur Garbin, captain of the Zadar artillerymen, was entered into registry books under the date 25 January 1621, and he was buried in the church of St. Demetrius near his family home. Grgur Garbin had two sons, both born in Zadar – Marco Antonio, baptised on 29 April 1609, and Ivan Grgur, baptised on 21st March 1611. Based on recent archival research, the author further learned that Garbin’s son Ivan Grgur, who died in Zadar in 1646, was professional goldsmith
Giovanni Garbini. Studioso e maestro.
No full textRaccolta di studi in commemorazione di Giovanni Garbin
Large Language Models in Action: Supporting Clinical Evaluation in an Infectious Disease Unit
No full textBackground/Objectives: Healthcare-associated infections (HAIs), including sepsis, represent a major challenge in clinical practice owing to their impact on patient outcomes and healthcare systems. Large language models (LLMs) offer a potential solution by analyzing clinical documentation and providing guideline-based recommendations for infection management. This study aimed to evaluate the performance of LLMs in extracting and assessing clinical data for appropriateness in infection prevention and management practices of patients admitted to an infectious disease ward. Methods: This retrospective proof-of-concept study analyzed the clinical documentation of seven patients diagnosed with sepsis and admitted to the Infectious Disease Unit of San Bortolo Hospital, ULSS 8, in the Veneto region (Italy). The following five domains were assessed: antibiotic therapy, isolation measures, urinary catheter management, infusion line management, and pressure ulcer care. The records, written in Italian, were anonymized and paired with international guidelines to evaluate the ability of LLMs (ChatGPT-4o) to extract relevant data and determine appropriateness. Results: The model demonstrated strengths in antibiotic therapy, urinary catheter management, the accurate identification of indications, de-escalation timing, and removal protocols. However, errors occurred in isolation measures, with incorrect recommendations for contact precautions, and in pressure ulcer management, where non-existent lesions were identified. Conclusions: The findings underscore the potential of LLMs not merely as computational tools but also as valuable allies in advancing evidence-based practice and supporting healthcare professionals in delivering high-quality care
Nuclear factor kappa B in patients with a history of unstable angina: case re-opened
No full textThis study aims at assessing NF-kB activity in unstable angina (UA) patients free of symptoms after a 1 year follow-u
Le Petit Néant 3
No full textLe Petit Néant is a publication which looks at drawing and the “wordless visual narrative.” Brought to life by Giulia Garbin (in charge of “the design and the visual aspects”) and Miguel Angel Valdivia when the duo were studying at the RCA, Le Petit Néant presents illustrators’ work captionless and without comment: a pure, unadulterated look at the medium in a world overrun with opinions
How and why to screen for CYP2D6 interindividual variability in patients under pharmacological treatments
No full textCytochromes P450 are members of a superfamily of hemoproteins that catalyze a variety of oxidative reactions in the metabolism of endogenous and exogenous hydrophobic substrates. Fifty-eight cytochrome P450 (CYP) isoenzymes belonging to 18 families have been identified in human cells; the corresponding genes are highly polymorphic, and genetic variability underlies interindividual differences in drug response. The polymorphisms of CYP2D6 significantly affect the pharmacokinetics of about 50% of the drugs in clinical use, which are CYP2D6 substrates. The number of functional CYP2D6 alleles per genome determines the existence of four different phenotypes, i.e. poor, intermediate, extensive, and ultrarapid metabolizers. CYP2D6 genetic variants include copy number variations, single nucleotide substitutions, frameshift and insertion/deletion mutations. This review reports some of the different methodological approaches used to screen for CYP2D6 variants and focuses on methods that have improved variation detection, from conventional techniques to more recent microarray technology and high throughput DNA sequencing. In addition, this review reports some results on
clinical relevance of CYP2D6 polymorphisms and provides examples of variability in drug response associated with interindividual phenotypic differences
Enhancing Institutional Trust: Evidence from an Experimental Study with Adolescents in Italy
No full textThis study presents a quantitative analysis of a randomized survey experiment with Italian high school students (N = 1,433). It aims to evaluate trust levels in various institutions-healthcare, education, politics, judiciary, and defense-and identify determinants influencing trust in the scientific field, particularly regarding health issues. Using experimental scenarios, potential causal relationships among factors influencing confidence and trust scores are explored. Three distinct experimental scenarios are included in the survey: the first examines the influence of various social media platforms, the second and the third evaluate the impact of doctors, parents, and friends on trust-building among young individuals. Our results indicate a high level of trust in science among adolescents and emphasize high confidence in scientific experts. The study provides policy insights aimed at fostering trust, including recommendations for investments in education, increased involvement of specialists in direct communication, and enhanced transparency measures to mitigate misinformation. © The Author(s), under exclusive licence to Springer Nature B.V. 2025
Le Petit Néant 3
No full textLe Petit Néant is a publication which looks at drawing and the “wordless visual narrative.” Brought to life by Giulia Garbin (in charge of “the design and the visual aspects”) and Miguel Angel Valdivia when the duo were studying at the RCA, Le Petit Néant presents illustrators’ work captionless and without comment: a pure, unadulterated look at the medium in a world overrun with opinions
Use of linguistic models for the analysis of the clinical nursing records of patients admitted to the Infectious Diseases unit
No full textreservedQuesta tesi esplora l'impiego di modelli linguistici avanzati, come ChatGPT, per l'analisi automatizzata delle cartelle medico-infermieristiche dei pazienti ricoverati nell'Unità Operativa di Malattie Infettive. L'obiettivo è utilizzare l'intelligenza artificiale per estrarre informazioni utili dai testi clinici non strutturati, migliorando l'identificazione di diagnosi, trattamenti e pattern rilevanti. I risultati potrebbero ottimizzare i processi decisionali e supportare la gestione clinica, contribuendo a una migliore assistenza ai pazienti
Correction to: Influence of cellulose nanofibrils on the rheology, microstructure and strength of alkali activated ground granulated blast-furnace slag: a comparison with ordinary Portland cement (Materials and Structures, (2021), 54, 1, (23), 10.1617/s11527-020-01614-5)
No full textLaura Riva and Carlo Punta have been added to the author group. The change of authorship is due to an error in the recognition of the role and importance of the work of synthesis and characterization of the materials object of the present study, which was not entirely recognized by the inclusion in the acknowledgements. A full recognition of the work performed is obtained by inclusion of the originally omitted authors in the authors’ list. Moreover, a recognition of these authors’ funding body was missing and has been included in the acknowledgement
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