2,079 research outputs found
Novi Sad massacre
No full textRoman "Novosadski pokolj" objavila je Jevrejska opština Novi Sad, a Košove transkripte ustupio im je njegov sin. Ova istorijska priča, koja svedoči o danima Novosadske racije, prvi put je objavljena 1949, a nakon toga, pisac je dopunio i kao konačnu verziju objavio kao roman, 1961.godine.The novel "Novi Sad Massacre" was published by the Jewish Community of Novi Sad, and Koš’s transcripts were lent to them by his son. This historic story, which testifies about the days during the Novi Sad Raid, was first published in 1949, and after that, the author supplemented it and published the final version as a novel in 1961
Interleukin-6 Receptor Blockade in Treatment- Refractory MOG-Ab–Associated Disease and Neuromyelitis Optica Spectrum Disorders
No full textBackground and objectives: To evaluate the long-term safety and efficacy of tocilizumab (TCZ), a humanized anti-interleukin-6 receptor antibody in myelin oligodendrocyte glycoprotein-IgG-associated disease (MOGAD) and neuromyelitis optica spectrum disorders (NMOSD).
Methods: Annualized relapse rate (ARR), Expanded Disability Status Scale score, MRI, autoantibody titers, pain, and adverse events were retrospectively evaluated in 57 patients with MOGAD (n = 14), aquaporin-4 (AQP4)-IgG seropositive (n = 36), and seronegative NMOSD (n = 7; 12%), switched to TCZ from previous immunotherapies, particularly rituximab.
Results: Patients received TCZ for 23.8 months (median; interquartile range 13.0-51.1 months), with an IV dose of 8.0 mg/kg (median; range 6-12 mg/kg) every 31.6 days (mean; range 26-44 days). For MOGAD, the median ARR decreased from 1.75 (range 0.5-5) to 0 (range 0-0.9; p = 0.0011) under TCZ. A similar effect was seen for AQP4-IgG+ (ARR reduction from 1.5 [range 0-5] to 0 [range 0-4.2]; p < 0.001) and for seronegative NMOSD (from 3.0 [range 1.0-3.0] to 0.2 [range 0-2.0]; p = 0.031). During TCZ, 60% of all patients were relapse free (79% for MOGAD, 56% for AQP4-IgG+, and 43% for seronegative NMOSD). Disability follow-up indicated stabilization. MRI inflammatory activity decreased in MOGAD (p = 0.04; for the brain) and in AQP4-IgG+ NMOSD (p < 0.001; for the spinal cord). Regarding only patients treated with TCZ for at least 12 months (n = 44), ARR reductions were confirmed, including the subgroups of MOGAD (n = 11) and AQP4-IgG+ patients (n = 28). Similarly, in the group of patients treated with TCZ for at least 12 months, 59% of them were relapse free, with 73% for MOGAD, 57% for AQP4-IgG+, and 40% for patients with seronegative NMOSD. No severe or unexpected safety signals were observed. Add-on therapy showed no advantage compared with TCZ monotherapy.
Discussion: This study provides evidence that long-term TCZ therapy is safe and reduces relapse probability in MOGAD and AQP4-IgG+ NMOSD
Processi di innovazione tecnologica in architettura: il ruolo dell’impresa, della ricerca, della didattica
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Arenediazonium tetrafluoroborates as initiators in the polymerisation of haloarene¬thiolates. A simple and mild access to poly(arylene sulfide)s
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Copyright and endogenous market structure: a glimpse from the journal-publishing market
No full textThis article explores the journal publishing industry in order to shed light on the overall economic consequences of copyright in markets. Since the rationale for copyright is among others to promise some market power to the holder of the successful copyrighted item, it also provides incentives to preserve and extend market power. A regular trait of copyright industries is high concentration and the creation of large catalogues of copyrights in the hands of incumbents. This outcome can be observed as the aggregation of rights and is one of the pivotal strategies for obtaining or extending market power, consistently with findings in other cases. Journal publishing is no different in this respect from other copyright industries, and in the last decade has experienced a similar trajectory, leading to a highly concentrated industry in which a handful of large firms increasingly control a substantial part of the market. It also provides a clear example of the effect of copyright dynamics on market structure, suggesting that a different attitude should be taken in lawmaking and law enforcement.copyright and market power, endogenous market structure, journal-publishing industry
Irreparable rotator cuff tears: challenges and solutions
No full textMichele Novi,1 Avinash Kumar,2 Paolo Paladini,3 Giuseppe Porcellini,4 Giovanni Merolla3,5 1Orthopaedic and Trauma Unit, University Hospital of Pisa, Pisa, Italy; 2Department of Orthopaedics, All India Institute of Medical Sciences, Patna, India; 3Shoulder and Elbow Unit, “D. Cervesi” Hospital, AUSL della Romagna, Ambito Territoriale di Rimini, Rimini, Italy; 4Orthopaedic and Trauma Unit, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy; 5“Marco Simoncelli” Biomechanics Laboratory, “D. Cervesi” Hospital, AUSL della Romagna, Ambito Territoriale di Rimini, Rimini, Italy Abstract: Irreparable rotator cuff tears are common conditions seen by shoulder surgeons, characterized by a torn and retracted tendon associated with muscle atrophy and impaired mobility. Direct fixation of the torn tendon is not possible due to the retracted tendon and lack of healing potential which result in poor outcome. Several treatment options are viable but correct indication is mandatory for a good result, pain improvement, and restoration of shoulder function. Patient can be treated either with a conservative program or surgically when necessary, by different available modalities like arthroscopic debridement, partial reconstruction, subacromial spacer, tendon transfer, and shoulder replacement with reverse prosthesis. The aim of this study was to review literature to give an overview of the available possible solutions, with indications and expected outcomes. Keywords: irreparable rotator cuff tear, arthroscopy, partial repair, tendon transfer, graft augmentatio
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