1,720,972 research outputs found
INFEZIONI ENDOVASCOLARI:RISULTATO DI UN'INDAGINE INTERNAZIONALE ENDOVASCULAR GRAFT INFECTION: RESULTS OF AN INTERNATINAL ENQUIRY
No full textProf. Fabrizio Benedetti Valentini, Prof. Paolo Negro, Prof. Mauro Liberatore, Membri Supplenti Prof. Giorgio Furio Coloni, Prof. Erino Angelo Rendina, Prof. Giuseppe De Vincentis
Thymoma and thymic carcinoma
No full textThymoma and thymic carcinoma are an extremely heterogeneous group of neoplastic lesions with an exceedingly wide spectrum of morphologic appearances. They show different presentations with a variable and unpredictable evolution ranging from an indolent non-invasive attitude to a highly infiltrative and metastasising one. Prognosis can be predicted on the basis of a number of variables, mainly staging, the WHO histological pattern and diameter of the tumour. Complete surgical resection is certainly the gold standard to achieve cure. However, especially in patients with lesions at advanced stage, complete resection may be difficult and recurrence often occurs; at these stages, disease-free long-term survival may be difficult to be accomplished. Chemo- and radiotherapy protocols have been designed to complete surgical treatment and improve results in inoperable patients as well, based on the reported sensitivity of thymic tumours to these treatment modalities. The integration of clinical staging and histology, with the new histogenetic morphological classification, has contributed to design multimodality treatment protocols that help to improve prognosis. Induction therapy can now be applied before surgery in patients with tumours considered inoperable, improving resectability and outcome without adding morbidity and mortality to the surgical procedure. This newly developed approach helps to reduce the recurrence rate and to ameliorate disease-free survival. New therapies are now being evaluated as for many other tumours; however, they still need confirmation in prospective randomised studies. In the future, integrated treatment modality should be incorporated in a standardised approach that goes from a careful assessment of histology, staging and lymph node status, and a constructive and non-empirical cooperation between medical and radiation oncologists, pathologists and thoracic surgeons. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved
Meccanismi molecolari delle neoplasie polmonari
No full textL’identificazione e lo studio dei meccanismi molecolari alla base delle neoplasie polmonari costituiscono un elemento di fondamentale
importanza per la comprensione della biologia dei tumori e per l’identificazione di nuovi componenti molecolari che possano essere
utilizzati come strumenti o bersagli per il disegno di approcci clinici innovativi per la terapia antitumorale.
In questo capitolo sono riassunti alcuni dei principali meccanismi molecolari coinvolti nella formazione e sviluppo del cancro del
polmone e nel processo di metastatizzazione tumorale
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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