6,319 research outputs found
CONTEMPORANEA & ELETTRONICA - Matteo Segafreddo, Giorgio Binda
No full textCD audio, con musica contemporanea di Matteo Segafreddo ed elettronica di Giorgio Binda
Mucosal expression of Basic Fibroblastic Growth Factor, Syndecan 1 and tumour necrosis factor-α in Crohn's disease in deep remission under treatment with anti-TNFα antibodies
No full textBackground & Aims: Both inflammation and fibrosis may be detected in Crohn's disease (CD). The molecular pattern of Basic Fibroblastic Growth Factor (bFGF) and Syndecan-1 (SD1) expression is altered in stenosing CD, but we do not know what the behaviour of this teamwork factor is in CD in deep remission under treatment with anti-TNFα antibodies. Our aim was to compare the expression of bFGF, SD1 and TNF-α in patients with CD in deep remission under treatment with Infliximab (IFX) or Adalimumab (ADA) and a control group of patients with active CD. Methods: We assessed the expression of bFGF, SD1 and TNF-α in 10 patients with active CD and in 28 patients with CD in sustained deep remission for at least 6 months. All patients underwent surveillance colonoscopy with biopsies, while receiving maintenance therapy with IFX or ADA. Analysis was conducted by real-time reverse transcriptase PCR (RT-PCR) in biopsy samples. Results: We found that bFGF, SD1 and TNF-α were significantly reduced under treatment with anti-TNFα versus controls (p=0.000). bFGF and SD1 expression were similar between IFX and ADA patients (p=0.335 and p=0.289, respectively), while TNF-α was significantly under-expressed in ADA patients (p=0.008). Conclusions: bFGF, SD1 and TNF-α are significantly reduced in CD patients in deep remission under treatment with anti-TNFα, likely as an expression of optimal control of inflammation. The significance of the TNF-α under-expression in patients under treatment with ADA with respect to those under treatment with IFX should be elucidated in further studies
Modelling and Simulation of Clearance in the Revolute Joints of Linkages
No full textPaper on CD, Vietri sul Mare, Salern
Investigation of structural questions on europium compounds by means of 151Eu Mössbauer spectroscopy
No full text151 Eu Mössbauer spectroscopy permits the determination of the symmetry of the site in which Eu is accommodated. It has been shown that the 151Sm F3 source can be considered a monochromatic source. This source was used to measure the line width of Eu3+ in a site with cubic symmetry, i. e. in a Cs2NaEuCl6 crystal. The isomer shift of commercial compounds used as standards (anhydrous EuF3 and EuS) was also measured. In the case of Cs2NaEu(N O2)6 hexanitritoelpasolite the trivalent europium ion is accommodated in a site with perfect cubic symmetry. In Eu(PO3)3 crystalline metaphosphate, the rare earth is located in a site which appears to be distorted with respect to cubic symmetry; this site has no threefold or fourfold symmetry axis
Nitrosylation of c heme in cd(1)-nitrite reductase is enhanced during catalysis
No full textThe reduction of nitrite into nitric oxide (NO) in denitrifying bacteria is catalyzed by nitrite reductase. In several species, this enzyme is a heme-containing protein with one c heme and one d(1) heme per mono-mer (cd(1)NiR), encoded by the nirS gene.
For many years, the evidence of a link between NO and this hemeprotein represented a paradox, given that NO was known to tightly bind and, possibly, inhibit hemeproteins, including cd(1)NiRs.
It is now established that, during catalysis, cd(1)NiRs diverge from "canonical" hemeproteins, since the product NO rapidly dissociates from the ferrous d(1) heme, which, in turn, displays a peculiar "low" affinity for NO (K-D = 0.11 microM at pH 7.0).
It has been also previously shown that the c heme reacts with NO at acidic pH but c heme nitrosylation was not extensively investigated, given that in cd(1)NiR it was considered a side reaction, rather than a genuine process controlling catalysis.
The spectroscopic study of the reaction of cd(1)NiR and its semi-apo derivative (containing the sole c heme) with NO reported here shows that c heme nitrosylation is enhanced during catalysis; this evidence has been discussed in order to assess the potential of c heme nitrosylation as a regulatory process, as observed for cytochrome c nitrosylation in mammalian mitochondria
Smokers’ lung cancer risk related to the cigarette-generated mainstream particles
No full textHighlights\ud
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• Application of a lung cancer risk model to smokers considering ultrafine particles\ud
• Measurement of particle concentrations in cigarette-generated mainstream aerosol\ud
• Excess life cancer risk for Italian smokers equal 2–6×10<sup>−1</sup>\ud
• Main contribution to the ELCR due to tobacco-specific nitrosamines\ud
• Great contribution due to the ultrafine particles (i.e. surface area metrics)\ud
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Abstract\ud
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Cigarette smoking represents the main cause of lung cancer events. This is due to the carcinogenic compounds condensed onto particles generated during the combustion process and then inhaled through the mainstream side (i.e. the cigarette filter side) of the cigarette. The present paper applied a novel lung cancer risk model, able to take into account both ultrafine and coarse particle toxicity, to the particle concentration levels measured in the mainstream aerosol of cigarettes in order to provide a useful provisional tool for testing different smoking scenarios.\ud
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To this end particle distributions and total concentrations in terms of number, surface area and mass aerosol metrics were measured at the mainstream side of five different cigarette brands using a condensation particle counter as well as mobility/aerodynamic particle sizers. On the basis of Italian smoking patterns and cigarette consumptions, the excess life cancer risk (ELCR) was then evaluated.\ud
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Particle concentrations equal to 3–6×10<sup>8</sup> part. cm<sup>−3</sup>, 60–120 mm<sup>2</sup> cm<sup>−3</sup>, and 5–9 g m<sup>−3</sup> for number, surface area and mass metrics, respectively, were measured. Most probable ELCR values ranged from 2×10<sup>−1</sup> to 6×10<sup>−1</sup> with the higher contribution due to the tobacco-specific nitrosamines and a minor (but still not negligible) contribution of B[a]p, Cd, and As.\ud
Keywords\ud
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excess lifetime cancer risk (ELCR); ultrafine particles; dose; cigarette; tobacco; SMPS; APS; lung cance
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
IL MUSEO MODERNO E IL MUSEO CONTEMPORANEO
No full textAL LIBRO E' ALLEGATO UN CD CHE CONTIENE GLI ABSTRACT IN LINGUA INGLES
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