1,721,474 research outputs found
Edilizia residenziale pubblica tra progetto e rappresentazione. Il possibile ruolo del BIM come strumento innovativo per la progettazione e gestione del costruito
No full textL’importanza del disegno come strumento di ricerca, riflessione e descrizione del progetto
No full textUnderstanding the design intentions in order to reconstruct the whole process that from the first sketches arrives to the definition of the project and subsequently to its graphic drafting is the only way to reach the deep knowledge of an architectural work.
After the imposition of digital tools that has opened up new potential to representation, it is important to focus on the fact that a design process cannot be based only and exclusively on modern representation tools because most of the time the manual skills, the creative self and the representation’s skill are flattened.
Therefore, think about a drawing as a real design methodology is important.
The design has the aim to return an environment in all its characteristics: from the early stage, in which the idea still manifests itself through preliminary diagrams and sketches, to that in which the project is completely described through technical drawings.
The creative process of the space derives from an abstract idea that later is defined in the project starting from the reworking of mental images, assimilated following a synthesis of experiences and perceptive/sensorial memories of places or spaces. But nowadays, automatic drawing tools require a good knowledge of geometry and drawing’s bases, so much to reaffirm the role of this as a natural extension of thought, instrument of knowledge, understanding, study and reasoning as a fundamental prerequisite of the design
TOcCARE Napoli: nuove funzioni e significati per una struttura ospedaliera nel Centro Antico
No full textThe historic center of Naples represents an interesting reference to the developing methods that can be valid for the other cities which have the same problems. The contents of this article deal with an argument that has already been analysed by the master degree of the university of Naples, Federico II " Progettazione d’eccellenza per la città storica. Dalla cultura del recupero alla cultura dell’innovazione" and examines the management, design and planning of complex interventions in historic urban areas. The complexity of this argument comes from an extraordinary mixture of architectural, engeneering and archeological aspects which suggest a multi-disciplined design approach
Il recupero e la riqualificazione sostenibile del patrimonio ospedaliero.Verso un nuovo paradigma progettuale fondato sul BIM
No full textThe buildings represent the physical form expressing the complex social, cultural and economic factors that characterize the way of life of a community. Many buildings, for several reasons, time after time get degrade. Among these, we can find many hospitals, which lie abandoned, because of both economical and functional reasons. In most cases they can be a resource for initiatives of building recover and urban regeneration. But we need a new design and representation approach. The traditional approach of building representation, based on the CAD methodology is passed from the use of BIM, a unique information tool, shared and updated for Building Lifecycle Management (BLM). This new instrument can be very helpful in approaching a new way of thinking about re-use and re-design old hospital buildings
Vasculitis and organ pathology: a practical approach to histological diagnosis and clinical-pathologic correlations
Full text linkVasculitides are a complex and pleomorphic group of diseases, involving all types of vessels and, potentially, all organs, with heterogeneous clinical manifestations. The clinical diagnosis can be challenging due to the diverse clinical manifestations, variable disease course, and overlapping features with other conditions. Overall, the histopathologic diagnosis is a crucial component in the clinical workup and plays a central role in guiding treatment decisions and prognosis estimation. However, reaching a diagnosis can be challenging, due to the complexity of the disease, and the variability in histological findings of these disorders, often caused by the development of secondary changes that may obscure the diagnostic features. Moreover, vasculitides are relatively rare, and many pathologists are unfamiliar with the disease and their diagnostic criteria, both in the biopsy and autopsy setting. This monographic issue collects papers focused on the updated classification of vasculitis, recommendations for sample histologic processing, and clues to the histopathologic diagnosis in diverse organs and systems, providing a practical approach to this complex disease. We also want to take this opportunity to honor the memory of our friend and colleague G. Rossi with the editorial written by some of his best friends. His great commitment as a pathologist and as a researcher, his personality, full of generous outbursts, and his ability to put himself completely at the service of the institutions in which he served professionally, are a legacy that helps all of us in our daily lives and professions
[Cardiomyopathies due to defective energy metabolism: morphological and functional features].
No full textCardiomyopathies are defined as diseases of the myocardium associated with cardiac dysfunction and are classified by morphological characteristics as hypertrophic (HCM), dilated (DCM) arrhithmogenic right ventricular (ARVC) and restrictive cardiomyopathy. These were once considered as specific diagnoses but there is now considerable evidence that many different gene mutations can cause these pathologies. In recent years, big emphasis has been given to the possibility that deregulation of cardiac metabolism may play a role in the mechanisms that lead to cardiac maladaptive remodelling. Cardiac energy metabolism is tightly controlled in mammalian organisms during development and in response to diverse dietary, physiologic, and pathologic conditions. The cardiac phenotype of many genetic diseases caused by mutations in proteins involved in mitochondrial energy production and/or homeostasis, underscores the importance of energetic pathway on cardiac function. For example, inborn errors in nuclear-encoded mitochondrial fatty acid oxidation (FAO) pathway enzymes and defects in fatty acid uptake are an important cause of childhood HCM and sudden death. Abnormalities in mitochondrial respiratory chain function, particularly those caused by mitochondrial DNA (mtDNA) mutations, are responsible for a heterogeneous group of clinical disorders, including isolated HCM. Mitochondrial cardiomyopathies (MCM) are characterized by an adverse clinical course with biventricular dilation and failure, even at a young age. Mutations in genes encoding the gamma2 subunit of AMP-activated protein kinase (PRKAG2), alpha-galactosidase A (GLA) and lysosome-associated membrane proteine-2 (LAMP2) can cause profound myocardial hypertrophy in association with electrophysiological defects. Unlike HCM due to sarcomere gene mutations, which is characterized by myofiber disarray and fibrosis, large cytosolic vacuoles characterize cardiomyopathy due to defect in energy metabolism. Ultrastructural analysis revealed massive mitochondrial proliferation in MCM and glycogen in complexes with protein and/or lipids in cardiomyopathy due to PRKAG2, GLA and LAMP2 mutations
Evaluation of gastrointestinal mtDNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
No full textMitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare disease characterized by severe gastro-intestinal (GI) dysmotility caused by mutations in the thymidine phosphorylase gene. Thymidine phosphorylase (TP) is involved in the control of the pyrimidine nucleoside pool of the cell. Reduced TP activity induces nucleotide pool imbalances that in turn affect both the rate and fidelity of mtDNA replication, leading to multiple deletions and depletion of mtDNA. By using laser capture microdissection and quantitative real-time-polymerase chain reaction technique, we showed that depletion of mitochondrial DNA (mtDNA) is the most prominent molecular defect in the gut wall of MNGIE patients. Depletion affects severely the smooth muscle cells of muscularis propria and the skeletal muscle component of the upper esophagus, while ganglion cells of the myenteric plexus show only a milder mtDNA reduction
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