8,847 research outputs found
Ordered Mesoporous Silica for Drug Delivery in Topical Applications
No full textThe aim of this PhD work was to develop and characterize all physicochemical aspects of this new CRT for CTZ and AKS using OMS until the introduction onto the market. The first part comprehends the characterization of different OMS synthesized and commercially available; the study of different incorporation techniques based on hydrophilicity/hydrophobicity of API; the characterization of the new impregnated OMS. Consequently, the work is oriented on the interaction details of API on silica surfaces. A closer look is given to the big questions of OMS-drug phenomena: mobility, solubility, bioavailability, etc. Therefore, all the scCO2 incorporation parameters have been studied, highlighting the differences between OMS and the spatial assembly of drug inside the mesoporous channels. Thus, the patented CRT has been developed for AKS describing all the main aspect of the innovative semisolid formulation. In-vitro and ex-vivo release test has been produced and characterized, revealing the functionality of the OMS reservoir effect. Finally, the same DDS have been developed for CTZ. Both the DDS have been compared with commercially available cream
Sustained release of amikacin sulfate from ordered mesoporous silica in the topical administration: development, characterization and comparison with commercial formulation
No full textAndrea Bacová
No full textAndrea Bacová focuses on research and teaching in the field of residential architecture. Her work includes systematic research on residential buildings and their urban context. She actively participates in promoting Slovak architecture and is the author of several publications and exhibitions
An organic-solvent-free route to obtain nanostructured zinc oxide-based reservoir of clotrimazole
No full textA green organic-solvent-free route to prepare nanostructured zinc oxide carriers of clotrimazole for pharmaceutical applications
No full textIn the context of proposing cleaner production strategies for the pharmaceutical industry, an organicsolvent-free route to prepare nanostructured zinc oxide (NsZnO) reservoirs of clotrimazole (CTZ) was studied. Two different NsZnO materials were synthesized, selecting wet chemical approaches without any organic solvents: chemical bath deposition and a soft-template sol-gel method. Both materials showed a pure crystalline wurzite structure with two different morphologies: aggregates of nanosheets or interconnected nanoparticles. For the former material the specific surface area and the pore volume reached the values of 66 m2/g and 0,230 cm3/g, respectively, which were higher than those of the latter (19 m2/g and 0,050 cm3/g). For the first time, the loading of CTZ in a ZnO carrier was performed using supercritical CO2 as a solvent. The NsZnO materials were characterized, before and after the drug loading, by FESEM, EDS, XRD, nitrogen adsorption isotherms, TGA, DSC. CTZ was dispersed in the NsZnO carrier in amorphous form, with a maximum loading of 17% w/w. The decrease of specific surface area and pore volume upon drug loading for both samples is ascribed to the adsorption of CTZ molecules on the surface of the NsZnO materials. This confirms the feasibility of using the NsZnO as a CTZ carrier. In vitro drug-release was investigated and revealed that the NsZnO carrier can deliver CTZ with a faster release of a larger drug amount when compared to the solid crystalline drug. The novel clean preparation route of a ZnO carrier for CTZ delivery herein presented is easily adabtable to batch small-scale pharmaceutical industrial process
Viewer-, Author-, and Ownership in the Work of Andrea Zittel
No full textAndrea Zittel invites others to collapse the distinctions between artist, viewer, and collaborator by interacting with her usable works. This thesis explores the process of interacting with Zittel\u27s works, and how it affects viewer-, author- and ownership
The Lettere of Andrea Calmo: authorial artifices and historical reality
No full textopenNonostante l’edizione di Vittorio Rossi del 1888, la raccolta di "ingegnosi cheribizzi" e di "fantastiche fantasie" di Andrea Calmo è ancora avvolta da un certo mistero. L’autore, dissimulando la propria identità dietro alla “maschera” dell’umile pescatore veneziano, è stato in grado di offrire uno spaccato della cultura e della società nella Venezia cinquecentesca.
In particolare, è il quarto libro delle Lettere ad aver suscitato maggiore interesse tra gli studiosi ed i lettori: pubblicato nel 1566, a diversi anni di distanza dai primi tre, questo libro si distingue per il fatto che tutte le epistole sono indirizzate a delle donne immaginarie o realmente esistite.
In questa sede si propone, in primo luogo, uno studio della biografia del Calmo accompagnata da un’analisi del contesto storico-culturale della Venezia cinquecentesca; in secondo luogo, invece, viene proposto un commento di alcune lettere dell’ultimo libro dell’opera calmiana, che cerchi di far luce principalmente sull’aspetto linguistico e contenutistico del testo.Despite Vittorio Rossi's 1888 edition, Andrea Calmo's collection of "ingegnosi cheribizzi" and "fantastiche fantasie" is still shrouded in a certain mystery. The author, dissimulating his own identity behind the "mask" of the humble Venetian fisherman, was able to offer a cross-section of culture and society in sixteenth-century Venice.
In particular, it is the fourth book of the Letters that has aroused greater interest among scholars and readers: published in 1566, several years after the first three, this book stands out for the fact that all the epistles are addressed to women imaginary or actually existed.
Here we propose, first of all, a study of Calmo's biography accompanied by an analysis of the historical-cultural context of sixteenth-century Venice; secondly, however, a commentary on some letters from the last book of Calmo's work is proposed, which seeks to shed light mainly on the linguistic and content aspect of the text
Simulation and Experiment Reveal a Complex Scenario for the Adsorption of an Antifungal Drug in Ordered Mesoporous Silica
No full textOrdered mesoporous silicas have been
widely investigated as drug
carriers in several fields, from tissue engineering to cancer therapy.
The knowledge of the specific interactions between the surface of
mesoporous silicas and drugs is necessary to guide development of
new and improved drug delivery systems. However, such knowledge is
still scarce, due to the arduous interpretation of experimental results.
In this work, we characterize the incorporation of clotrimazole, a
common antifungal drug, inside ordered mesoporous silica by means
of a joint computational and experimental approach. Experimentally
the drug was loaded through supercritical CO<sub>2</sub> and its adsorption
investigated through infrared spectroscopy, N<sub>2</sub> adsorption
isotherms, and thermogravimetric analysis. Modeling involved static
and dynamic Density Functional Theory simulations of clotrimazole
adsorbed on realistic models of amorphous silica surfaces. A good
agreement between the computational and the experimental results was
obtained, concerning the energies of adsorption, the infrared spectra,
and the distribution of drug inside the mesopores. However, a complete
interpretation of the experimental results was possible only when
simultaneously considering all the complex aspects of the drug–silica
interaction. Indeed, the combination of both approaches allowed us
to describe the drug–silica interface as a mix of multiple
interaction configurations, based on a subtle balance of hydrogen
bonding and dispersion interactions. Furthermore, at high drug loading,
clotrimazole molecules are statistically distributed on the pore walls,
forming an adsorbed molecular layer. Finally, notwithstanding the
stable interactions, the drug still exhibits a significant mobility
at room temperature, moving on a complex potential energy surface,
as revealed by molecular dynamics simulations
Trusted Tales: Creating Authenticity in Literary Representations from Ex-Yugoslavia
No full textThis research deals with questions of authority and authenticity and how they are expressed, constructed, and appropriated within the Anglophone book market. It considers the body of literature written about ex-Yugoslavia since the 1990s Balkan conflicts by exiled writers from the region which has entered the international literary canon. Books’ routes from original publishers into English translation are discussed through practices of trust, one of the crucial social devices underpinning their exchange. Within these cross-cultural processes, the role of cultural brokers is crucial. Symbolic and cultural resources are specifically mobilised through their powerful author brands.
By exploring authenticity in the context of book publishing, I further look at how ideas and practices of community are employed and negotiated by writers and those who promote their books. My field is multi-sited and fluid, reflecting how different individual and national positions are enacted and performed through strategies ranging from unconscious dispositions to deliberate intentions. This research thus brings together ideas of the author as an authentic, representative voice together with exile as a position that grants them a new lease of relevancy in the post-socialist context.
Although ex-Yugoslav books occupy a ‘high end’ niche of the UK market, constrained by commercial as well as political, cultural, and institutional forces, in public discourse ideas of the ‘free market’ and ‘free speech’ are mobilised to produce various types of modernisation narratives. The (post)socialist production of literature is perceived as having to ‘evolve’ into a capitalist model: this would allow not only healthy competition and consumer choice but guarantee an individual writer ‘free speech’ as a basic human right. Therefore, the most general question this research raises is what kind of foreign literature gets translated into English, under what socio-cultural conditions and which politics of representation it serves within the project of world literature
- …
