1,720,974 research outputs found
In Vivo Metabolic Responses to Different Formulations of Amino Acid Mixtures for the Treatment of Phenylketonuria (PKU)
Full text linkPhenylketonuria (PKU) is a rare autosomal recessive inborn error of metabolism where the mainstay of treatment is a Phe restricted diet consisting of a combination of limited amounts of natural protein with supplementation of Phe-free or low-Phe protein substitutes and special low protein foods. Suboptimal outcomes may be related to the different absorption kinetics of free AAs, which have lower biological efficacy than natural proteins. Physiomimic TechnologyTM is a technology engineered to prolong AA (AA-PT) release allowing physiological absorption and masking the odor and taste of free AAs. The aim of these studies was to assess the impact of AA-PT formulation on selected functional and metabolic parameters both in acute and long-term experimental studies. Adult rats in fasting conditions were randomized in different groups and treated by oral gavage. Acute AA-PT administration resulted in significantly lower BUN at 90 min versus baseline. Both BUN and glycemia were modulated in the same direction as intact casein protein. Long-term treatment with AA-PT significantly reduces the protein expression of the muscle degradation marker Bnip3L (−46%) while significantly increasing the proliferation of market myostatin (+58%). Animals dosed for 15 days with AA-PT had significantly stronger grip strength (+30%) versus baseline. In conclusion, the results suggest that the AA-PT formulation may have beneficial effects on both AA oxidation and catabolism with a direct impact on muscle as well as on other metabolic pathways
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells
No full textUse of a new hemicellulose dressing (Veloderm®) for the treatment of split-thickness skin graft donor sites. A within-patient controlled study
No full textA multi-centre, open, within-patient controlled study was performed on 23 adult burnt patients to investigate the effectiveness, safety and tolerability of Veloderm® in comparison with Algisite MTM and Jaloskin® in split-thickness skin graft donor site care. The areas dressed with Veloderm® completely healed within 10-13 days in a significant higher proportion than the other two dressings (47.6% for Veloderm® versus 26.3% for Algisite MTM and 10% for Jaloskin®, P < 0.03), showing during the whole study less incidence of exudates and of peri-lesional erythema. The aesthetic outcome of the treated lesions after healing was significantly better for Veloderm® (P = 0.0016). Veloderm® and Jaloskin® required very few renewals of the medication during the first week of treatment, while Algisite MTM needed several multiple re-dressings. Veloderm® was judged better than the other two treatments as far as the acceptability (P < 0.001), ease of use (P < 0.001) and efficacy (P < 0.00001). Both pain during application or at removal of dressings and local infections were negligible with all treatments. No scars were formed in any skin donor site. In conclusion Veloderm® is a safe and effective dressing for the re-epithelialization of the skin graft donor sites: it showed higher activity than the other two compared dressings. © 2006 Elsevier Ltd and ISBI
The role of Mical-2 gene in myogenic differentation
Full text linkThe dystrophin-glycoprotein complex (DGC) is composed of several transmembrane and peripheral components localized in the sarcolemma of skeletal muscle. Mutations in genes that encode DGC components lead to the loss of either expression and/or function of the DGC in muscle. As DGC complex interacts with F-actin it is reasonable that the multidomain F-actin binding protein MICAL2 that transduces semaphorin/plexin external signaling into cytoskeletal modifications, might interact either directly or indirectly with the DGC complex. MICAL2 is indeed expressed in skeletal and cardiac muscles and drosophila Mical mutants reveal that the architecture of contractile muscle filaments is negatively affected. We focus here on the role of MICALs in myogenic differentiation. The rationale to investigate MICAL2 in muscle differentiation is also highlighted in a paper regarding a complex muscle genome-wide expression profiling during the disease evolution in mdx mice, a mouse model of Duchenne muscular dystrophy (1). In this study the authors found MICAL2 among a set of totally ten functionally linked genes involved in the decline of muscle necrosis in mdx mice. For this purpose MICAL2 gain and loss of function studies have been performed in myogenic cell line and compared to in vivo analysis of MICAL2 expressions in acute and chronic muscle degeneration. Recently we showed that that differential myogenic propensity influences the commitment of isogenic induce pluripotent stem cells and a specifically isolated pool of mesodermal iPSC-derived progenitors (MiPs) toward the striated muscle lineages (2). Analysis of MICAL2 expression in MiPs is currently under investigation. Taken together modulation of MICAL2 has an impact on skeletal muscle commitment and could be considered a potential therapeutic target for Duchenne patients. This work was supported with the contribution of “Opening The Future” Campaign [EJJ-OPTFUT-02010] CARIPLO 2015_0634, FWO (#G088715N, #G060612N, #G0A8813N), and IUAP-VII/07 (EJJ-C4851-17/07-P) grants
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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