169,844 research outputs found
Measurement Based Reconfigurations in Optical Ring Metro Networks
No full textSingle-hop wavelength division multiplexing (WDM) optical ring networks operating in packet mode are one of themost promising architectures for the design of innovative metropolitan network (metro) architectures. They permit a cost-effective design, with a good combination of optical and electronic technologies, while supporting features like restoration and reconfiguration that are essential in any metro scenario. In this article, we address the tunability requirements that lead to an effective resource usage and permit reconfiguration in optical WDM metros.We introduce reconfiguration algorithms that, on the basis of traffic measurements, adapt the network configuration to traffic demands to optimize performance. Using a specific network architecture as a reference case, the paper aims at the broader goal of showing which are the advantages fostered by innovative network designs exploiting the features of optical technologies
Sclerostin: A novel player regulating bone mass in inflammation ?
No full textInflammation is a common albeit overlooked cause of local and systemic bone loss which results from an imbalance between bone formation and bone resorption. The Wnt pathway, which plays an essential role in the regulation of bone turnover, has been proposed as a potential molecular link between inflammation and inflammatory bone loss. We here recapitulate present knowledge about sclerostin, a Wnt pathway inhibitor, and bone damage in inflammation. A better understanding of sclerostin action and regulation might help in designing an effective treatment strategy in inflammatory bone loss. Copyrigh
Strategie nel trattamento conservativo del piede torto congenito
No full textClubfoot is one of the most common congenital abnormalities and,
therefore, only a proper and early treatment can avoid a permanent
deformity.
Since clubfoot can determine many different clinical patterns, conservative treatment includes several strategies in order to face this
pathology timely, such as Ponseti’s method and the French functional
method. A review of the latest international literature about the
comparison between these two methods allows to state that the choice of one or the other must vary following the severity of the deformity, the social and economic context of the patient’s family but, mainly, the specific problems of each individual patient, who will have to undergo a long follow-up period in order to check the good
outcome of the treatment and to avoid relapses
The penguin has entered the building: the commercialization of open source software products
No full textPrevious literature on open source software (OSS) mostly analyzes organizational issues within communities of developers and users. This paper focuses on for-profit organizations that release software products under OSS licenses, and argues that variations in their endowments of intellectual property rights, namely patents and trademarks, help to determine which firms will tend to incorporate OSS into commercial products. We explain whether and under what conditions preexisting stocks of intellectual property rights can be useful complementary assets that allow firms to benefit directly or indirectly from commercializing OSS products, and test our hypotheses on a novel data set built on firms’ announcements of OSS product releases in the specialized press between 1995 and 2003. We find three robust results: (a) firms with large stocks of software patents are more likely to release OSS products; (b) firms with large stocks of software trademarks are less likely to release OSS products; (c) firms with large stocks of hardware trademarks are more likely to release OSS products.Publicad
Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: gender oriented diagnostic tools
No full textBackground and objectives: The research of opportune strategies for facilitating the management of complex pathologies, such as ascending aorta aneurysm (AAA), currently represents the principal object of clinicians, clinical pathologists included. Herein, we propose genotyping of gene variants related to TGF-β pathway as useful strategy to improve the complex AAA management, exclusively based on imaging evaluations. Precisely, we investigated four functional SNPs in SMAD and VEGF genes, encoding molecules able to modulate functions and cross-talks of TGF-β pathway.
Populations and methods: Our study included 92 individuals (70 men (76%) and 22 (24%) women; mean age: 71.4 ± 2.6 years) affected by sporadic AAA, and two age/gender matched control groups. Kaspar PCR geno- typing and opportune histopathological/immune-histochemical techniques were used.
Results: Interestingly, we evidenced a significant association of CT + TT genotypes of SMAD3 rs3825977 gene variant with a higher AAA risk in women patients. CT + TT genotypes of SMAD3 rs3825977 gene variant positively correlated with the major conventional risk factors of AAA, a higher tissue aorta levels of metallo- proteinase (MMP)-9 and a higher significant medial degeneration characterized by a higher grade of severity in elastic fragmentation. To the best of our knowledge, this is the first study on the association and relationship between SMAD3 rs3825977 gene variant and AAA. Several crucial aspects remain, however, to clear. Conclusions: We believe that further investigations, such as the analysis of SMAD3 gene transcripts and tissue proteins are imperative
Masters of War: Rivals’ Product Innovation and New Advertising in Mature Product Markets.
No full textWe investigate the impact of rivals' product innovation and new advertising on a firm's financial market value in mature product markets. Our test bed is the carbonated soft drink market between 1999 and 2003, a period characterized by a near duopoly between Coca-Cola and Pespi. Empirically, we focus on new product announcements as a proxy of product innovation and on filed trademarks as a measure of new advertising. We find that rival product announcements decrease a firm's financial market value, and that rival filed trademarks increase it. Finally, we find that the effect of new advertising is channeled through market size dynamics, while that of product innovation operates through market share dynamics. Results are robust across different estimation techniques (event study, Tobin's q) and model specifications.Product innovation; Advertising; Firm value; Rivalry; Trademarks;
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Polymorphisms of pro-inflammatory IL-6 and IL-1β cytokines in ascending aortic aneurysms as genetic modifiers and predictive and prognostic biomarkers
No full textBackground: Previous studies have demonstrated that polymorphisms involved in immune genes can affect the risk, pathogenesis, and outcome of thoracic ascending aortic aneurysms (TAAA). Here, we explored the potential associations of five functional promoter polymorphisms in interleukin-6 (IL-6), IL-1B, IL-1A, IL-18, and Tumor necrosis factor (TNF)A genes with TAAA. Methods: 144 TAAA patients and 150 age/gender matched controls were typed using KASPar assays. Effects on telomere length and levels of TAAA related histopathological and serological markers were analyzed. Results: Significant associations with TAAA risk were obtained for IL-6 rs1800795G>C and IL-1B rs16944C>T SNPs. In addition, the combined rs1800795C/rs16944T genotype showed a synergic effect on TAAA pathogenesis and outcome. The combined rs1800795C/rs16944T genotype was significantly associated with: (a) higher serum levels of both cytokines and MMP-9 and-2; (b) a significant CD3+CD4+CD8+ CD68+CD20+ cell infiltration in aorta aneurysm tissues; (c) a significant shorter telomere length and alterations in telomerase activity. Finally, it significantly correlated with TAAA aorta tissue alterations, including elastic fragmentation, medial cell apoptosis, cystic medial changes, and MMP-9 levels. Conclusions: the combined rs1800795C/rs16944T genotype appears to modulate TAAA risk, pathogenesis, and outcome, and consequently can represent a potential predictive and prognostic TAAA biomarker for individual management, implementation of innovative treatments, and selection of the more proper surgical timing and approaches
The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming
No full textThe research on neurodegenerative diseases (NeuroDegD) has been traditionally focused on later life stages. There is now an increasing evidence, that they may be programmed during early development. Here, we propose that NeuroDegD are the result of the complex process of imprinting on fetal hemogenic endothelium, from which the microglial cells make to origin. The central role of placenta and epigenetic mechanisms (methylation of DNA, histone modifications and regulation by non-coding RNAs) in mediating the short and long-term effects has been also described. Precisely, it reports their role in impacting plasticity and memory of microglial cells. In addition, we also underline the necessity of further studies for clearing all mechanisms involved and developing epigenetic methods for identifying potential targets as biomarkers, and for developing preventive measures. Such biomarkers might be used to identify individuals at risk to NeuroDegD. Finally, the sex dependence of fetal programming process has been discussed. It might justify the sex differences in the epidemiologic, imaging, biomarkers, and pathology studies of these pathologies. The discovery of related mechanisms might have important clinical implications in both the etiology of disorders and the management of pregnant women for encouraging healthy long-term outcomes for their children, and future generations. Impending research on the mechanisms related to transgenerational transmission of prenatal stress might consent the development and application of therapies and/or intervention strategies for these disorders in humans
Product strategies and survival in schumpeterian environments: evidence from the US security software industry.
No full textThis paper seeks to explore the drivers of survival in environments characterized by high rates of entry and exit, fragmented market shares, rapid pace of product innovation and proliferation of young ventures. The paper aims to underscore the role played by postentry product strategies, along with their interaction, after carefully controlling for "at entry" factors and demographic conditions. Based on a population of 270 firms that entered the US security software industry between 1989 and 1998, we find evidence that surviving entities are those that are more aggressive in the adoption of versioning and portfolio broadening strategies. In particular, focusing on any one of these two strategies leads to a higher probability of survival as opposed to adopting a mixed strategy.Survival; Versioning; Portfolio broadening; Young ventures; Sotware;
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