4,277 research outputs found
Marilyn Weigold
No full textDr. Marilyn E. Weigold is professor of history at Pace University and serves as the official Pace University Historian. She is the author of the official history book of Pace University entitled Opportunitas: the History of Pace University. David Finn, photographs.https://digitalcommons.pace.edu/pace-women/1031/thumbnail.jp
INFLUENCE OF MICRO- AND MACROENVIRONMENT IN COLON CANCER
No full textAn increasing body of evidence supports a contribute of the immune system in cancer development and progression, in fact recent data have demonstrated that, virtually, every tumor has an inflammatory cell infiltrate as part of a complex tumor microenvironment (TME). Cancer progression is also directed by the involvement of organs located at distant sites from the primary tumor due to the release of tumor-derived soluble factors (TDSFs). Therefore, it is very important to consider not only the role of the tumor-associated stroma, which is known as TME, but also the creation of a network even with distal compartments due to the release of many TDSFs leading to the generation of the so-called tumor macroenvironment. Recently, the macroenvironment changes have been underlined in the genetic model of colon cancer ApcMin/+, where a significantly higher total IgA levels in ApcMin/+ tumor-bearing mice has been demonstrated. In this work, the possible mechanisms of the IgA skewing have been dissected in the colorectal cancer (CRC) context. The data demonstrated that the sole IgA skewing is not a tract present in all CRC models, but that it is peculiar of the ApcMin/+ mice; the presence of the IgA sewing in mouse tumor models not associated with the intestinal tract was also excluded. Considering the association of several intestinal diseases with increased intestinal permeability, the damaged intestinal barrier, which can lead to the translocation of bacteria, was proposed to be associated with the tumor progression. A higher presence of bacterial level in the ApcMin/+ compared to the WT mice was detected, indicating an increased microbial translocation to the liver. Furthermore, the presence of Bacteroides fragilis in the ApcMin/+ mice was found, a type of bacteria that was instead absent in the WT counterpart. Our data indicate the carcinogenic potential of the microbiota in the ApcMin/+ tumor context, since it has been demonstrated a tumorigenic role for B. fragilis. The data, herein presented, suggest a direct or indirect association of the microbiota in the ApcMin/+ tumor setting compared to the healthy mice. The progresses in the study of the immune microenvironment have mainly highlighted the role of immunosuppressive T cell in the inhibition of the antitumor immune response. Instead, the role of B cells is less well understood. In the present work, the presence of a accumulation of MDSCs in the CRC TME and the ability of splenic MDSCs from MC38 tumor-bearing mice to affect the phenotype of B cells, inducing a shift towards an immunosuppressive B cell phenotype, have been highlighted. In particular, the ability of splenic MDSCs isolated from MC38 tumor-bearing mice was reported to induce the expansion of the IL-10 competent B cells and to increase the expression of FasL, PD-L1, and IgA on naïve B cells. This work might be, therefore, helpful for clarifying the alteration of the systemic tumor environment occurring in CRC and for the development of new potential immunotherapeutic strategies
Janetta Rebold Benton
No full textJanetta Rebold Benton is Distinguished Professor of Art History and Director of the Pforzheimer Honors College, serving the five undergraduate colleges, at Pace University, Pleasantville, NY. Dr. Benton has lectured every season since the spring of 1988 for the Metropolitan Museum of Art and lectures also at The Cloisters in New York; Smithsonian Institution and National Gallery of Art in Washington, DC; Boston Museum of Fine Arts; Society of the Four Arts in Palm Beach; and elsewhere in America and abroad. A former resident of Paris, she taught courses in art history there as the Art Historian at the American Embassy.
The author of seven books, the fourth edition of ARTS AND CULTURE: AN INTRODUCTION TO THE HUMANITIES (Robert DiYanni co-author, Prentice Hall, Upper Saddle River, NJ, two volumes, combined volume) was published in 2011, including a Chinese translation. Her book, MATERIALS, METHODS, AND MASTERPIECES OF MEDIEVAL ART, is available in hardcover and as an E-book (Praeger series on the Middle Ages, ABC-CLIO, Santa Barbara, CA, 2009). Her book, MEDIEVAL MISCHIEF: WIT AND HUMOUR IN THE ART OF THE MIDDLE AGES (Sutton Publishing, Stroud, Gloucestershire, 2004), studies an engaging aspect of medieval art. ART OF THE MIDDLE AGES (Thames & Hudson, London, 2002) was published in the acclaimed World of Art series. HOLY TERRORS: GARGOYLES ON MEDIEVAL BUILDINGS (Abbeville Press, NY, 1997) was published also in French as SAINTES TERREURS: LES GARGOUILLES DANS L\u27ARCHITECTURE MÉDIÉVALE (second edition, 2000). Dr. Benton was the guest curator and catalog author for the 1995 exhibition MEDIEVAL MONSTERS: DRAGONS AND FANTASTIC CREATURES at the Katonah Museum of Art, Katonah, NY. Her book, THE MEDIEVAL MENAGERIE: ANIMALS IN THE ART OF THE MIDDLE AGES (Abbeville Press, NY, 1992), a Book of the Month Club selection, was published also in French as BESTIAIRE MÉDIÉVAL: LES ANIMAUX DANS L\u27ART DU MOYEN AGE. Articles by Dr. Benton appear in the Metropolitan Museum of Art’s exhibition catalog, SET IN STONE: THE FACE IN MEDIEVAL SCULPTURE, 2007, as well as in scholarly journals including Cahiers de Civilisation Médiévale, Poitiers, 1998; Arte Medievale, Rome, 1993; Artibus et Historiae, Vienna, 1989; Zeitschrift für Kunstgeschichte, Munich, 1985; and others.
Dr. Benton was educated at Harvard University, Graduate School of Education, MDP diploma; took her Ph.D. in Medieval and Renaissance Art at Brown University; Master\u27s degree in Classical Art at George Washington University; and undergraduate degree in Fine Arts at Cornell University.https://digitalcommons.pace.edu/pace-women/1029/thumbnail.jp
Navigating Identity, Belonging, and Purpose in a Society in Flux
No full textChris Rabb is a family historian, author, and thought leader at the intersection of social identity, civic innovation, and equity. This is a lightly edited transcript of his 2023 Dyson Distinguished Lecture delivered at the Elisabeth Haub School of Law at Pace University on October 25, 2023
Architects? We Don\u27t Need No Stinkin\u27 Architects
No full textThe author chronicles the participation of the Library staff in the renovation of Pace Law Library
Launching a New Environment Court: Challenges and Opportunities
No full textThis is the text of a speech given at the International Symposium on Environmental Courts and Tribunals, hosted by Pace Law School and the International Judicial Institute for Environmental Adjudication (IJIEA), on April 1, 2011, in White Plains, New York. Any annotations to the text of this speech have been added by the author in connection with its publication in this Special Edition
We, the Judges, and the Environment
No full textThis is the text of a speech given at the International Symposium on Environmental Courts and Tribunals, hosted by Pace Law School and the International Judicial Institute for Environmental Adjudication (IJIEA), on April 1, 2011, in White Plains, New York. Any annotations to the text of this speech have been added by the author in connection with its publication in this Special Edition
The Environment as Life Sources and the Writ of Kalikasan in the Philippines
No full textThis is the text of a speech given at the International Symposium on Environmental Courts and Tribunals, hosted by Pace Law School and the International Judicial Institute for Environmental Adjudication (IJIEA), on April 1, 2011, in White Plains, New York. Any annotations to the text of this speech have been added by the author in connection with its publication in this Special Edition
Lessons from a Lawyer’s Life
No full textThe author, scholar-in-residence at Pace Law School, received the 2013 ABA Award for Distinguished Achievement in Environmental Law and Policy. A pioneer in the early years of environmental protection, she expands in this space on her remarks in accepting the honor, drawing insights for today’s environmental professionals
The Russian Dreiser: A Faculty-Student Research Project on Russian Attitudes Toward an Important American Social Protest Novelist
No full textThis faculty-student research project focuses on the literary naturalist, Theodore Dreiser (1871-1946). Author of numerous novels including An American Tragedy (1925), Dreiser remains the subject of controvery both in the United States and in the former Soviet Union, two of the many venues where he was ardently read in the years following the Russian Revolution and beyond. The student in this project - Jeanna Engelman - bring a very special perspective to this analysis of Dreiser for she first encountered Dreiser as a young girl growing up in the former USSR. Attending the Cherkassay #19 High School in the Ukraine, Jeanna studied Dreiser as a proletarian author. Since coming to the U.S. in 1990 and now studying at Pace University, Jeanna\u27s project was to revisit this key American social protest writer - this time from a new perspective gained through life in the U.S., her mature reflections on life in the former Soviet Union, her understanding of family dynamics (she\u27s a wife and mother), and her major studies in the area of speech pathology and language
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