117,406 research outputs found
7, Fermo Ghisoni da Caravaggio, L'Assunzione della Vergine
No full textScheda dedicata al dipinto di Fermo Ghisoni raffigurante l'Assunta, già pala d'altare maggiore del Santuario della Beata Vergine delel Grazie di Curtatone presso Mantova. Il disegno dell'opera è di Giulio Romano
Prevalence and type distribution of high-risk human papillomavirus infection in women undergoing voluntary cervical cancer screening in Italy
No full textThe aim of this survey was to assess the prevalence and distribution of oncogenic human papillomavirus (HPV) genotypes in women who underwent screening for cervical cancer in Italy. The correlation of genotypes with the cytological results was also evaluated. Cervical samples were collected from 9,947 self-referring women for cervical cancer screening. Participants were screened by liquid-based cytology and high-risk HPV testing using the Hybrid Capture 2 test. Positive samples were genotyped by PCR. Samples (1,474; 14.8%) were positive for high-risk HPV. The prevalence was 29.4% in the 15-19 years-group, decreasing progressively to 6.1% at 50-54 years of age and increasing to 12.2% in those aged over 65 years. HPV 16 was the genotype detected most frequently followed by HPV 31, HPV 18, HPV 56, and HPV 51. HPV 16 or 18 were present in 4% of women with normal cytology and both were detected contemporarily in only 14 women. Twenty-two percent of atypical squamous cells, 26% of low-grade and 56% of high-grade squamous intraepithelial lesions at cytology were positive for HPV 16 and/or 18. The prevalence of HPV infection in Italy is in agreement with that reported worldwide. HPV 16 was the prevalent genotype. The concomitant infection with HPV 16 and HPV 18 (vaccine targets) was found rarely. Apart from HPV 16 and 18, there was a substantial presence of HPV genotypes against which the vaccines available currently have shown cross-protection efficacy. The findings of this study may contribute to reliable predictions on the potential efficacy of an HPV vaccine in clinical practice. J. Med. Virol. 81:529-535, 2009. (C) 2009 Wiley-Liss, Inc
Changes in extra-virgin olive oil added with Lycium barbarum L. carotenoids during frying: Chemical analyses and metabolomic approach
No full textIn this work, an Italian extra-virgin olive oil (EVOO) sample and the same sample added with a carotenoid-rich
nutraceutical extract from Lycium barbarum L. (EVOOCar) were subjected to a frying process to comparatively
assess chemical and physical changes and heat stability. Oxidation progress was monitored by measuring oil
quality changes such as peroxide value, free acidity, K232, K268, and fatty acid composition as well as minor
compound content, phenols, α-tocopherol, and carotenoids. An UHPLC/QTOF-MS metabolomics approach
discriminated the two oil samples based on their chemical changes during frying, identifying also the phenolic
classes most exposed to statistically significant variations. Partial least square discriminant analysis and volcano
analysis were applied together to identify the most significant markers allowing group separation. The decrease
in total phenolic content was lower in EVOOCar than in EVOO during frying. Monounsaturated and polyunsaturated
fatty acids showed a significant percentage loss, 3.7% and 17.2%, respectively, in EVOO after
180 min frying at 180 °C, while they remained constant or slightly changed in EVOOCar. Zeaxanthin added to
the oil rapidly decreased during the frying process. These findings showed that the addition of a carotenoid
extract from L. barbarum can help to improve the oxidative stability of extra-virgin olive oil
Esiste la “teoria del gender”?
No full textLa "teoria/ideologia del gender" è un costrutto retorico utilizzato da movimenti reazionari per contrastare le conquiste dei diritti dei movimenti femministi e LGBTQI+. Lungi dal corrispondere agli studi di genere e alle teorie queer, ne è una caricatura deformante
Predictability of duration and severity of congenital hydronephrosis as a cause of smooth muscle deterioration in pyelo-ureteral junction obstruction
No full textLack of improvement in cerebral metabolism after hyperoxia in severe head injury: A microdialysis study
No full textObject. The authors investigated the effects of hyperoxia on brain tissue PO2 and on glucose metabolism in cerebral and adipose tissue after traumatic brain injury (TBI). Methods. After 3 hours of ventilation with pure O2, 18 tests were performed on different days in eight comatose patients with TBI. Lactate, pyruvate, glucose, glutamate, and brain tissue PO2 were measured in the cerebral extracellular fluid (ECF) by using microdialysis. Analytes were also measured in the ECF of abdominal adipose tissue. After 3 hours of increase in the fraction of inspired O2, brain tissue PO2 rose from the baseline value of 32.7 ± 18 to 122.6 ± 45.2 mm Hg (p < 0.0001), whereas brain lactate dropped from its baseline (3.21 ± 2.77 mmol/L), reaching its lowest value (2.90 ± 2.58 mmol/L) after 3 hours of hyperoxia (p < 0.01). Pyruvate dropped as well, from 153 ± 56 to 141 ± 56 μmol/L (p < 0.05), so the lactate/pyruvate ratio did not change. No significant changes were observed in glucose and glutamate. The arteriovenous difference in O2 content dropped, although not significantly, from a baseline of 4.52 ± 1.22 to 4.15 ± 0.76 ml/100 ml. The mean concentration of lactate in adipose tissue fell significantly as well (p < 0.01), but the lactate/pyruvate ratio did not change. Conclusions. Hyperoxia slightly reduced lactate levels in brain tissue after TBI. The estimated redox status of the cells, however, did not change and cerebral O2 extraction seemed to be reduced. These data indicate that oxidation of glucose was not improved by hyperoxia in cerebral and adipose tissue, and might even be impaired
Miscarriage diagnosis and gestational age estimation in the early first trimester of pregnancy: transvaginal versus transabdominal sonography
No full textA comparison is made between 290 patients examined using transabdominal sonography and 308 patients examined using transvaginal sonography. Patients with suboptimal menstrual histories and threatened miscarriages were excluded from these two groups of patients. The transabdominal and transvaginal sonography examinations were carried out while the patient's bladder was empty, so that there was no delay between the clinical and sonographic examinations. In this way there was no patient discomfort from a full bladder. In normal pregnancies after 42 days of amenorrhea, the percentage visualization rates of the chorionic sac, of the embryo with heart activity and of the yolk sac were measured. There were no significant differences between the two groups. The two techniques were able to provide a reliable diagnosis of miscarriage on embryos >or= 4 mm or with chorionic sacs >or= 10 mm mean diameter. However, before 42 days of gestation, transvaginal sonography was better than transabdominal sonography at diagnosing miscarriage. The percentage of anembryonic pregnancies was higher in the transabdominal sonography group (21%) than in the transvaginal sonography group (7%), despite similar gestational ages at the time of a positive diagnosis. Thus, a transabdominal scan can be used after 42 days and borderline cases can be referred for transvaginal sonography for confirmation
Lack of improvement in cerebral metabolism after hyperoxia in severe head injury : a microdialysis study
No full textObject. The authors investigated the effects of hyperoxia on brain tissue PO2 and on glucose metabolism in cerebral and adipose tissue after traumatic brain injury (TBI).
Methods. After 3 hours of ventilation with pure O-2, 18 tests were performed on different days in eight comatose patients with TBI. Lactate, pyruvate, glucose, glutamate, and brain tissue PO2 were measured in the cerebral extracellular fluid (ECF) by using microdialysis. Analytes were also measured in the ECF of abdominal adipose tissue.
After 3 hours of increase in the fraction of inspired O-2, brain tissue PO2 rose from the baseline value of 32.7 +/- 18 to 122.6 +/- 45.2 mm Hg (p < 0.0001), whereas brain lactate dropped from its baseline (3.21 +/- 2.77 mmol/L), reaching its lowest value (2.90 +/- 2.58 mmol/L) after 3 hours of hyperoxia (p < 0.01). Pyruvate dropped as well, from 153 +/- 56 to 141 +/- 56 mumol/L (p < 0.05), so the lactate/pyruvate ratio did not change. No significant changes were observed in glucose and glutamate. The arteriovenous difference in O-2 content dropped, although not significantly, from a baseline of 4.52 +/- 1.22 to 4.15 +/- 0.76 ml/100 ml. The mean concentration of lactate in adipose tissue fell significantly as well (p < 0.01), but the lactate/pyruvate ratio did not change.
Conclusions. Hyperoxia slightly reduced lactate levels in brain tissue after TBI. The estimated redox status of the cells, however, did not change and cerebral O-2 extraction seemed to be reduced. These data indicate that oxidation of glucose was not improved by hyperoxia in cerebral and adipose tissue, and might even be impaired
Intra-amniotic pressure is not affected by amniocentesis between 13 and 18 weeks of gestation
No full textChanges in amniotic fluid pressure before and after amniocentesis fell within the range of +/- 5 mmHg, except when uterine contractions were present. Intra-amniotic pressure is not affected by amniocentesis between 13 and 18 weeks of gestation. Amniotic fluid pressure was recorded in 82 pregnancies of patients undergoing genetic amniocentesis to determine whether sampling of amniotic fluid between 13 and 18 weeks changed intra-amniotic pressure. Pressures were recorded through a needle and saline filled catheter with a zero-level at the needle tip. Amniotic fluid pressure was unrelated to gestational age (P = 0.962) during the weeks we performed our measurements. Fluid samples of 12.6% of the total volume in a group of early genetic amniocentesis (n = 65) and of 7.5% of the total volume in a group of late genetic amniocentesis (n = 17) did not change significantly amniotic fluid pressure values. An increase in pressure of more than 5 mmHg only occurred in cases where uterine contractions were present. Other than these cases, all pressure change values fell within the range of +/- 5 mmHg. No difference in pregnancy outcome were present within the two groups. An argument for a standard method for stationing pressure is presented
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