1,720,990 research outputs found
Effects of a paracetamol and tramadol fixed-dose combination on pain, asthenia, cognitive disorders and sleep quality in fibromyalgia
No full textFibromyalgia (FM) is a complex syndrome associated with a wide range of symptoms such as as-thenia, sleep disturbance and cognitive disorders, that frequently lead to wrong diagnoses and pointless tests or examinations. We focused our attention on a fixed combination of tramadol 37.5 mg + paracetamol 325 mg in a retrospective observational study on sixty-nine consecutive outpatients. An improvement in pain was observed in almost all patients , with a statistically significant reduction in VAS (8.1 vs. 5.5; p<0.001), Evoked Pain Score (2.7 vs. 2.0; p<0.001) and FM-related symptoms. The combined mechanism of action of paracetamol and tramadol are not merely analgesic: they may also provide a "ground-based" approach to FM and can be a valid analgesic treatment as they act on pain and on the associated symptom
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Serum growth-promoting activity measured as [3H]thymidine incorporation into human activated lymphocytes and serum transferrin levels in newborns and mothers
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Treatment of cryoglobulinemic neuropathy with alpha-interferon. Neurology. 1996 Feb;46(2):588-9
No full textWe read with interest the article by Khella et al on the treatment of cryoglobulinemic neuropathy with alpha-interferon (alpha-IFN). Our group has been studying the relationship between HCV and essential mixed cryoglobulinemia (EMC) since 1990. We are a collaborating center of the Italian Group for the Study of Cryoglobulinemias (GISC), and have recently published the results obtained from a large sample (654 patients with EMC). In this context, we have also studied the occurrence of cryoglobulinemia-related neuropathy. Our experience refers mainly to symmetrical and sensory motor neuropathies, although we have studied some cases of mononeuropathy multiplex. The observation that alpha-IFN was able to improve cryoglobulinemic vasculitis led us to investigate its effects on the peripheral nervous system, although some authors reported a worsening of peripheral neuropathy during therapy with alpha-IFN .Ten cryoglobulinemic patients with sensory motor polyneuropathy and HCV infection were treated with alpha-IFN at a dose of 3 mU, three times per week, for a period of 6 to 12 months. Seven patients treated for 6 to 12 months with deflazacort at a dose of 0.5 mg/kg/day were recruited as controls. All patients were submitted to a scoring test to establish the significance of neurologic symptoms (NSS scale) and an EMG study to evaluate: (1) the amplitude of peroneal motor action potential; (2) the sural sensory conduction velocity; (3) the ulnar F-wave latency, and (4) the ulnar and peroneal motor conduction velocities. A significant improvement of peripheral neuropathy was seen only in the group treated with alpha-IFN, as determined by the NSS scale. However, their EMG data at the end of therapy were not significantly different from those of the control patients. Nonetheless, it should be pointed out that in a patient with mononeuropathy multiplex, we did not see any improvement following 1 year of therapy with steroids and alpha-IFN However, in the same patient, treatment with cyclophosphamide was associated with a substantial regression of the symptoms with electroneurographic evidence of reinnervation (unpublished data).Therefore, we agree with Khella et al that cryoglobulinemic vasculitis in patients with HCV infection may benefit from treatment with alpha-IFN. However, a clinical and/or EMG improvement would not necessarily occur in all cases following this therapy. Further studies are needed to ascertain if higher dosages of alpha-IFN or other types of IFN, such as beta-IFN, are able to improve the electroneuromyographic findings
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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