190,659 research outputs found
Un diritto “gnostico”. Considerazioni su Il DirItto come estetIca di Morris L. Ghezzi
No full textMorris Ghezzi filosofo del diritto e interprete moderno della gnosi antica
Un diritto “gnostico”. Considerazioni su Il DirItto come estetIca di Morris L. Ghezzi
No full textMorris Ghezzi filosofo del diritto e interprete moderno della gnosi antica
Roma 1726: le pietre di Pier Leone Ghezzi fra cronaca e storia
No full textIn merito al Manoscritto 322 della Biblioteca Universitaria Alessandrina di Pier Leone Ghezzi intitolato Studio di molte pietre e datato 1726 (pubblicato in questo volume per la prima volta), in cui il pittore romano riproduce ad acquerello 265 tra pietre e paste vitree, l'autore affronta nel suo capitolo la ricostruzione degli interessi litologici di Ghezzi e soprattutto (attraverso documenti d'archivio inediti) della figura del celebre scalpellino romano Francesco Guidotti, l'alter ego del Ghezzi medesimo riguardo alla tecnologia dei materiali disegnati e dipinti nel codice
Oxidoreduction of protein thiols in redox regulation
No full text: Protein cysteines can undergo various forms of oxidation, some of them reversible (disulphide formation, glutathionylation and S-nitrosylation). While in the past these were viewed as protein damage in the context of oxidative stress, there is growing interest in oxidoreduction of protein thiols/disulphides as a regulatory mechanism. This review discusses the evolution of the concept of redox regulation from that of oxidative stress and the redox state of protein cysteines in different cellular compartments
Commento all'art. 2380 del codice civile - Sistemi di amministrazione e controllo
No full textIl lavoro commenta l'art. 2380 c.c. che disciplina i diversi modelli di amministrazione e controllo che possono essere utilizzati dalle s.p.a
Effect of N-acetyl-L-cysteine on sepsis in mice
No full text: The effect of the antioxidant N-acetyl-L-cysteine was studied in a model of polymicrobial sepsis induced in CD-1 mice by cecal ligation and puncture. N-Acetyl-L-cysteine significantly improved survival during the 6 days following sepsis induction and caused lower liver toxicity. This effect was not related to free radicals generated by xanthine oxidase which was significantly induced in liver after cecal ligation and puncture. A specific inhibitor of xanthine oxidase, allopurinol, significantly reduced this enzyme and reduced the early survival rate. The effect of N-acetyl-L-cysteine was not related either to a reduction in tumor necrosis factor production or to a modulation of nitrites or to liver glutathione content. These results show that the induction of xanthine oxidase is not deleterious in this model of sepsis and suggest that N-acetyl-L-cysteine works as a direct antioxidant and scavenger of free radicals generated from other sources
Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron
No full text: Treatment of mice with endotoxin (lipopolysaccharide, LPS) and the two LPS-induced monokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), caused a depression of liver cytochrome P-450 and related drug-metabolizing enzymes, as well as other acute-phase changes including increase in plasma fibrinogen levels and hypoferremia. However, only IL-1, not TNF or LPS, depressed cytochrome P-450 in cultured hepatocytes, suggesting that the effect of TNF in vivo might be mediated by a second mediator. TNF- or LPS-stimulated monocytes released a factor capable of depressing cytochrome P-450 in cultured hepatocytes. This factor was inhibited by anti-IL-1 antiserum, and its synthesis, like that of IL-1, was inhibited by dexamethasone (DEX). Pretreatment of mice with DEX protected against the depression of liver cytochrome P-450 by LPS or TNF but not by IL-1, suggesting that IL-1 directly depresses cytochrome P-450 and that DEX acts by inhibiting IL-1 synthesis in vivo induced by LPS or TNF. However, DEX did not inhibit two other effects of LPS and TNF in vivo: increase of plasma fibrinogen levels and decrease of plasma iron, suggesting that these might not be mediated by IL-1. Therefore, the effect of DEX in vivo, although supporting the hypothesis that depression of liver cytochrome P-450 by LPS and TNF is mediated by IL-1, indicates the existence of IL-1-independent pathways in the acute-phase response
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