3,297 research outputs found
The North is another country. by Nicolas Rothwell
No full texttag=1 data=The North is another country. by Nicolas Rothwell
tag=2 data=Rothwell, Nicolas
tag=3 data=Australian Magazine,
tag=6 data=16/17 November 1996
tag=7 data=20-33.
tag=8 data=NT%TOURISM
tag=10 data=Worse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North.
tag=11 data=1996/2/8
tag=12 data=96/0316
tag=13 data=CABWorse, better, stranger, wilder, but above all different from the rest of the country. Continuing his journey of discovery across Australia's Top half the author stops over in Darwin to hear all the truths and whispers about the North
Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008
No full textZufferey Nicolas. Grace S. Fong, Herself an Author : Gender, Agency, and Writing in Late Imperial China, 2008. In: Études chinoises, n°28, 2009. Numéro spécial sur le droit chinois. pp. 243-247
New Necklaces: 400 Designs in Contemporary Jewellery
No full textAfter the successful New Rings and New Earrings, New Necklaces is the third book curated by jeweller and author Nicolas Estrada, from classic forms and materials to the most daring, experimental and surprising ideas, each of the 500 necklaces included in this book has something that makes it unique and relates strongly to today's social, cultural and artistic reality. With prefaces by German jeweller Julia Wild and Leo Caballero, owner of the Barcelona gallery Klimt 02, specialised in contemporary jewellers
How Did I Get to Princess Margaret? (And How Did I Get Her to the World Wide Web?)
No full textThe paper explores the growing use of
tools from the arts and humanities for investigation
and dissemination of social science research.
Emerging spaces for knowledge transfer, such as
the World Wide Web, are explored as outlets for
"performative social science". Questions of ethnics
and questions of evaluation which emerge from
performative social science and the use of new
technologies are discussed. Contemporary thinking
in aesthetics is explored to answer questions
of evaluation. The use of the Internet for productions
is proposed as supporting the collective
elaboration of meaning supported by Relational
Aesthetics.
One solution to the ethical problem of performing
the narrations of others is the use of the writer's
own story as autoethnography. The author queries
autoethnography's tendency to tell "sad" stories and
proposes an amusing story, exemplified by "The
One about Princess Margaret" (see Appendix).
The conclusion is reached that the free and open
environment of the Internet sidelines the usual
tediousness of academic publishing and begins to
explore new answers to questions posed about
the evaluation and ethics of performative social
science
Identification of author profiles through social networks
No full textThe aim of this paper is to compile dictionaries of slang words, abbreviations, contractions, and emoticons to help the pre-processing of texts published in social networks. The use of these dictionaries is intended to improve the results of the tasks related to data obtained from these platforms. Therefore, a hypothesis was evaluated in the task of identifying author profiles (author profiling).Silva, JesúsMaria Santodomingo, Nicolas EliasRomero, LigiaJorge, MarisolHerrera, MaritzaPineda Lezama, Omar Bonerg
Nikolski de Nicolas Dickner. - américanité, archéologie, intertextualité
No full textAuthor treats different dimensions of space in Nicolas Dickner's novel Nikolski. He analyses the way in which the novel ties links between space and family and, furthermore, outlines the role stratification plays in the novel
SCAD-zbMATH-01 Open Access Data Set for Author Name Disambiguation (AND) (Enhanced Version)
No full text<p>This data set contains disambiguated publication data from zbMATH (www.zbmath.org) for use in author name disambiguation (AND). It covers 28321 publications with 33810 authorship records, authored by 2946 distinct authors. Authorship records have been manually annotated with author identifiers.</p>
<p>This download includes additional data sets for advanced, selective disambiguation.</p>
<p>For details, see "Mark-Christoph Müller, Florian Reitz, and Nicolas Roy (2017): Data Sets for Author Name Disambiguation: An Empirical Analysis and a New Resource", Scientometrics, doi:10.1007/s11192-017-2363-5.</p>
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Sur les traces de Nicolas Bouvier, sur des cailloux atlantiques
No full textThe author of this travelogue follows in the footsteps of Nicolas Bouvier on the Aran Islands off the coast of Ireland. By surveying the almost deserted island of Inishmore in the middle of winter, he seeks to understand what fascinated the author of The Way of the World on these Atlantic stones twenty years earlier.L'auteur de ce récit de voyage suit les traces de Nicolas Bouvier sur les îles d'Aran au large de l'Irlande. En arpentant en plein hiver l'île quasi déserte d'Inishmore, il cherche à comprendre ce qui a fasciné vingt ans plus tôt l''auteur de L'Usage du monde sur ces cailloux atlantiques.Gauthier Lionel. Sur les traces de Nicolas Bouvier, sur des cailloux atlantiques. In: Le Globe. Revue genevoise de géographie, tome 160, 2020. Sur les pas de... pp. 93-98
Causes et conséquences de l’activation de l’interféron de type I dans les maladies auto-immunes. Étude dans le modèle du syndrome de Sjögren
No full textPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease (AID) that presents similar characteristics to systemic lupus erythematosus. These characteristics include pathophysiology and genetic factors. Our team and other groups have highlighted an interferon (IFN) signature in salivary glands and PBMCs from patients with Sjögren syndrome. This signature demonstrates new pathways in pSS and lupus, focusing research on innate immunity and in the IFN pathway.We have confirmed the implication of 2 genes in the pSS, and these genes are involved in the IFN pathway. The first gene is IRF5 which is in the type I IFN pathway and the second is STAT4 which is in the type II IFN pathway. We have shown a functional consequence of IRF5 at-risk allele. Regarding STAT4, the associated SNP did not altered STAT4 mRNA expression but was highly correlated with type I IFN genes expression.The epigenetic deregulation could play a triggering role in autoimmune diseases, particularly through DNA methylation which is highly implicated in the suppression of gene expression. We studied the methylation of IRF5 promoter and found no methylation. Our team is currently undertaking a global approach with methylome analysis. This methylome study will assess specific gene methylation patterns and will allow a better understanding of the role of these genes in autoimmune diseases.We further demonstrated that IL-12 specifically induces a type I IFN signature through a CD4+ T cells and pDCs crosstalk. These results could explain the implication of STAT4 polymorphism not only in type II IFN-dependent AIDs but also in type I IFN-dependent AIDs. Our data confirm that type I IFN- and type II IFN-mediated AIDs do not have to be opposed. They are only the yin and the yang of a common STAT4 activation which may induce secretion of both cytokines.Le syndrome de Sjögren primitif (SSp) est une maladie auto-immune (MAI) systémique ayant des caractéristiques communes avec le lupus érythémateux. Ces caractéristiques incluent des mécanismes physiopathologiques et des facteurs de predispositions génétiques. Notre équipe et d’autres groupes ont pu mettre en evidence une signature interféron (IFN) dans les glandes salivaires et les PBMCs de patients ayant un SSp. Cette découverte a permis de mettre en évidence de nouvelles voies à explorer dans la pathogénie du SLE et SSp en permettant la focalisation des recherches sur le rôle de l’immunité innée et de la voie IFN.Nous avons confirmé le rôle de 2 gènes importants dans le SSp, impliqués dans les voies des IFN. Le premier est IRF5 sur la voie IFN de type I et STAT4 sur la voie IFN de type II. Nous avons pu mettre en évidence une fonctionnalité de l’allèle à risque d’IRF5 (Polymorphisme Indel situé dans le promoteur). Concernant STAT4, son expression n’était pas altérée par le SNP associé à la maladie. Toutefois, l’ARNm de STAT4 était corrélé à l’expression des gènes IFN de type I. Les dérégulations épigénétique pourraient jouer un rôle important dans la pathogénie de nombreuses MAI, en particulier la méthylation de l’ADN qui est hautement liée à l’extinction de l’expression des gènes. Nous avons étudié la méthylation du promoteur d’IRF5 et nous n’avons pas trouvé de régulation de ce promoteur par le méthylation. Une analyse de la méthylation avec une approche globale du méthylome est en cours dans notre équipe et permettra d’identifier de gènes cibles d’une dérégulation épigénétique pouvant être impliqués dans les MAI.Nous avons essayé de comprendre la relation entre STAT4 et gènes IFN de type I. Ainsi, nous rapportons que l’IL-12 induit spécifiquement l’IFN de type I par intéraction entre deux partenaires cellulaires, les lymphocytes T CD4+ et les cellules dendritiques plasmacytoïdes. Ces résultats pourraient expliquer l’implication des polymorphismes de STAT4 dans les MAI dépendantes de l’IFN de type I. Ces résultats suggèrent également que les MAI dépendantes des IFN de type I et II ne s’opposent pas. Elles seraient seulement le Yin et le Yang d’un facteur d’activation commun, STAT4, capable d’induire les IFNs de type I et II
Data, R scripts and ASReml scripts
No full text################################################################################################
# OBJECTIVE: Procedure to perform the data handling and the analyses + details about the files #
# AUTHOR: Nicolas Bedere ([email protected]) #
# LICENCE: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication #
# LAST UPDATE: 2023-01-06 #
# PLATFORM: x86_64-pc-linux-gnu (64-bit) #
################################################################################################
#### INTRODUCTION ####
This text files aims to explain the procedure to perform both the data handling and the analyses
in the paper:
#### Description of the files:
#1. Datasets
PhenoAsreml.txt contains the observed values for the phenotypes described in the paper
PhenoAsreml_scaled.txt contains the scaled (mean of zero and standard deviation of one) of the same phenotypes. THIS DATASET IS USED FOR BIVARIATE ANALYSES WITH 2x2 STRATA
PhenoAsreml_scaledLong.txt contains the same information, organized differently because the dataset is reshaped from wide to long format.
PhenoAsreml_scaledLong_3x3strata.txt contains the information for BackFat and BodyWeight, THIS DATASET IS USED FOR BIVARIATE ANALYSES WITH 3x3 STRATA
PhenoAsreml_scaledLong_3x2strata.txt contains the information for BackFat and Adiponectin, THIS DATASET IS USED FOR BIVARIATE ANALYSES WITH 3x2 STRATA. It is only an example of dataset that needs to be generated in order to obtain all the results presented in the paper
BEDERE_2023_Data_PedigreeHens.txt is the pedigree file (individual/sire/dam) traced back over 5 generations
#2. Codes and parameter files
BEDERE_2023_RScript_handlingdata_Long.R is an R code to reshape PhenoAsreml_scaled into PhenoAsreml_scaledLong and to subset it to generate PhenoAsreml_scaledLong_3x3strata for instance
BEDERE_2023_ASREMLScript_bivariate_2x2strata.as (as well as ...3x2strata.as and ...3x3strata.as) are ASReml parameter files used to state the data, model specification and post-hoc calculation to ASReml
Please, note that some variance components have been fixed in some analyses when the algorithm was struggling to converge.
BEDERE_2023_RScript_BartlettTest.R is an R code to perform the Bartlett test.
#2. Results examples
Some output files of ASReml are provided to give an example of results for each type of bivariate analysis.
The .asr file is the log of the program, explaining how the program ran
The .res file is describing the residuals
The .pvc file describes the variance components and provides the genetic parameters with their associated standard errors.<br
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