1,064 research outputs found
Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality
No full textThiel C, Lübke T, Matthijs G, von Figura K, Körner C. Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality. Molecular and Cellular Biology. 2006;26(15):5615-5620
Minimal Delaunay Triangulations of Hyperbolic Surfaces
No full textMotivated by recent work on Delaunay triangulations of hyperbolic surfaces, we consider the minimal number of vertices of such triangulations. First, we show that every hyperbolic surface of genus g has a simplicial Delaunay triangulation with O(g) vertices, where edges are given by distance paths. Then, we construct a class of hyperbolic surfaces for which the order of this bound is optimal. Finally, to give a general lower bound, we show that the Ω(√g) lower bound for the number of vertices of a simplicial triangulation of a topological surface of genus g is tight for hyperbolic surfaces as well
Societal need for multifunctional flood defenses: Introduction
No full textProf.dr.ir. Matthijs Kok is Professor of Flood Risk at the Faculty of Civil Engineering and Geosciences at TU Delft; he was Program leader of the ‘Integral and Sustainable Design of Multifunctional Flood Defenses’ research program, funded by the Dutch Science and Technology Foundation STW. Presently, he is Program leader of the STW-Perspectief research program ‘All RISK’, which will study the implementation of new risk standards in the Dutch national flood protection program (2017-2022). Hydraulic Structures and Flood Ris
Experimental study on bed-material transport over entrance sills at longitudinal training walls
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Rivers, Ports, Waterways and Dredging EngineeringEnvironmental Fluid Mechanic
Exploring informed choice in preconception reproductive genetic carrier screening by using a modified Multidimensional Measure of Informed Choice
No full textOBJECTIVES: To explore informed choice in reproductive genetic carrier screening (RGCS). METHODS: Women visiting a gynaecologist practice in Flanders (Belgium) were asked to consider participation in a study where RGCS was offered for free to them and their male partner. A modified Multidimensional Measure of Informed Choice was used to determine whether couples who opted for RGCS made an informed choice. In addition, we assessed risk perception, feelings towards RGCS, anxiety and decisional conflict. RESULTS: Most participants (82 %, n = 63/77) made an informed choice with regard to RGCS according to our modified MMIC. Thirteen participants made an uninformed choice due to insufficient knowledge and one participant because of insufficient knowledge and value-inconsistency. Anxiety scores were elevated for three participants. Two participants presented with decisional conflict. CONCLUSION: Our results show high rates of informed choice among non-pregnant couples who were offered RGCS in a research study and received up to 30 min of pre-test counseling. PRACTICE IMPLICATIONS: Limited resources outside a research context may impact informed choice. Pre-test counselling initiatives for RGCS should ideally be organized in such a way that information can be provided at multiple time points to avoid information overload and to allow for a reflection period.sponsorship: This project was financially supported by the Research Fund Flanders (FWO) (grant number G094518N). (Research Fund Flanders (FWO), G094518N)status: Publishe
Are couples making informed choices when opting for reproductive genetic carrier screening?
No full textResearch Fund Flanders (FWO) [G094518N
Are couples making informed choices when opting for reproductive genetic carrier screening?
No full textResearch Fund Flanders (FWO) [G094518N
A New Missense Mutation in theCASRGene in Familial Interstitial Lung Disease with Hypocalciuric Hypercalcemia and Defective Granulocyte Function
No full textThe support of the Broere Charitable Foundation is
acknowledge
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