170,629 research outputs found
Ambulatory capacity in cerebral palsy: prognostic criteria and consequences for intervention
No full textIn conclusion, although the importance of encouraging the development of physical abilities remains, in certain cases we cannot simply wait for years to see whether a child will eventually become an effective walker as a result of physiotherapy or orthopaedic interventions. Powered mobility should be considered as a means of providing efficient, autonomous locomotion for children with severe motor disabilities, so enabling them to become more active participants in their own lives rather than remaining spectators. Children with moderate levels of motor impairment could be encouraged to see wheelchair use as beneficial in some circumstances and not an irreversible failur
The beginning of wisdom is paranoia : an overlooked aspect of the 'fear of Yhwh' in the context of Lacanian psycho-epistemology : Old Testament wisdom, human dignity and the poor
No full textMuch has been written on the concept of 'the fear of Yhwh' in biblical wisdom literature. The scope thereof is said to include anything from sheer terror before the deity to pious respect for benevolence. In this article, a different necessary property of the basic disposition is identified. It is argued that if as many texts in the Hebrew Bible state a) wisdom involves the fear of Yhwh, and that b) possessing knowledge of some sort is a necessary condition for having wisdom, and that c) all knowledge is essentially paranoiac as Lacanian psycho-epistemology suggests, then it follows that d) the quest for wisdom itself is partly driven by paranoia.http://reference.sabinet.co.za/document/EJC13374
First Total Synthesis of the Bioactive Anthraquinone Kwanzoquinone C and Related Natural Products by a Diels–Alder Approach
No full textThe first total synthesis of the novel anticancer agent kwanzoquinone C (1), an anthraquinone glycoside which has been isolated from extracts of the roots of orange daylilies (Kaempfer) (Hemerocallis fulva) is reported. The strategy involves the preparation of the tetrasubstituted 1,3-butadiene 6 by an electrocyclic conrotatory ring opening of the cyclobutanone rac-11, which is obtained by a [2+2] cycloaddition. Diels-Alder reaction of 6 with the juglone derivative 5 gives the bis-benzyl-protected anthraquinone 4 after aromatization. Finally, glycosidation of the phenolic hydroxy group using 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl trichloroacetimidate followed by the cleavage of the benzyl ethers and the solvolysis of the acetate groups yields the natural product 1. A related anthraquinone natural product 2 with antioxidative properties was obtained by using the 1,3-butadiene 17 and the juglone derivative 16 as substrates. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Enantioselective total synthesis and structure determination of the antiherpetic anthrapyran antibiotic AH-1763 IIa
No full textTotal synthesis of the proposed structure of the anthrapyran metabolite delta-indomycinone
No full textThe first total synthesis of the proposed structure of delta-indomycinone has been accomplished. The key steps involve the Diels-Alder reaction of a bromonaphthoquinone (6) and 1-methoxy-3-methyl-1-trimethylsiloxy- 1,3-butadiene (7) to access the anthraquinone skeleton, representing a common building block of other naturally occurring anthraquinone antibiotics, regioselective bromination of anthraquinone (14) and a highly diastereoselective alkylation of enantiomerically pure dioxotanone 8. The reported synthetic approach has the advantage of high yields, excellent selectivity and a remarkable general applicability for the total synthesis of other anthrapyran natural products. ne spectroscopic data obtained for the synthetic compounds 2 and 36 are not in agreement with those reported for the natural product, and therefore revision of the assigned structure is required
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity
No full textHighly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels-Alder reaction as key step. The introduction of the proposed pharmaco-phoric side chain unit has been achieved by an addition of an aryllithimn species onto different aldehydes. Furthermore, the antitumor activity of these novel compounds has been studied by the in vitro growth inhibition of human lung carcinoma cells of line A549. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
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