342 research outputs found
Gerald Pizzuto Folder
No full text2 pages of family history documents containing and related to Gerald Pizzuto; Alberta L. Herndon; Dale D. Herdon' Judge George Reinhart - including: The Star News, The Idaho Statesma
The concept of reality as seen through the works of Antonio Pizzuto /
No full textLike many other authors of the experimental genre, Pizzuto believed that the conceptual framework imposed upon reality by literary tradition was too restrictive and illusory. In taking up the challenge of reality in a contemporary context which also demanded deference to a sophisticated modern audience, the author presents a composite image of the whole which cannot be captured except in its multiplicity through mimicry, satire, parody, lyricism and elements of the fantastic. Pizzuto's refreshing and unique style may be seen in four major areas: the presentation of reality, the depiction of time, character portrayal and lastly, word technique. The simultaneous interaction of these elements in Pizzuto's production brings a bold new dimension to the portrayal of reality and to the Italian literary scene. Essentially, this is the substance of the thesis
Kinematic Segmentation and Velocity in Earth Flows: A Consequence of Complex Basal-slip Surfaces
No full textAbstractWe investigated relations between geomorphic structures, movement velocity, and basal-slip surface geometry within individual kinematic domains of two large earth flows in the Apennine Mountains of southern Italy: the “Montaguto” earth flow and the “Mount Pizzuto” earth flow. Our analyses indicated that the earth flows are composed of distinct kinematic zones characterized by specific deformational patterns and longitudinal velocity profiles. Variations in velocity within individual kinematic zones is controlled by the geometry of the basal-slip surface, and, in particular by local variations in slope angle. Slip-surface geometry and slope also seem to control the density of extensional structures in driving earth-flow elements
Radiomics in Oncological PET Imaging: A Systematic Review-Part 2, Infradiaphragmatic Cancers, Blood Malignancies, Melanoma and Musculoskeletal Cancers
Full text linkThe objective of this review was to summarize published radiomics studies dealing with infradiaphragmatic cancers, blood malignancies, melanoma, and musculoskeletal cancers, and assess their quality. PubMed database was searched from January 1990 to February 2022 for articles performing radiomics on PET imaging of at least 1 specified tumor type. Exclusion criteria includd: non-oncological studies; supradiaphragmatic tumors; reviews, comments, cases reports; phantom or animal studies; technical articles without a clinically oriented question; studies including <30 patients in the training cohort. The review database contained PMID, first author, year of publication, cancer type, number of patients, study design, independent validation cohort and objective. This database was completed twice by the same person; discrepant results were resolved by a third reading of the articles. A total of 162 studies met inclusion criteria; 61 (37.7%) studies included >100 patients, 13 (8.0%) were prospective and 61 (37.7%) used an independent validation set. The most represented cancers were esophagus, lymphoma, and cervical cancer (n = 24, n = 24 and n = 19 articles, respectively). Most studies focused on 18F-FDG, and prognostic and response to treatment objectives. Although radiomics and artificial intelligence are technically challenging, new contributions and guidelines help improving research quality over the years and pave the way toward personalized medicine
Collegium Musicum, October 23, 1980
No full textConcert program for Collegium Musicum, October 23,
198
Collegium Musicum, October 23, 1980
No full textConcert program for Collegium Musicum, October 23,
198
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11
No full textCaspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 functions, as well as their clinical potential for the treatment of LPS-linked diseases through CASP4/11 inhibition. Here, we identify mitochondrial cardiolipin as a selective inhibitor of CASP4/11-dependent cell death and inflammatory cytokine secretion, without affecting CASP1 function. Cardiolipin targets the CARD domain of CASP4/11, impeding its interaction with LPS to restrain CASP4/11 activation, thereby suppressing LPS-induced systemic inflammation in vivo. By identifying cardiolipin as a selective inhibitor of CASP4/11, we provide an urgently needed tool for studying caspase-4/11 and noncanonical inflammasome functions in inflammatory pathways and LPS-induced pathogenesis.
© 2025. The Author(s)
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Full text linkAuthor Correction: Spatial communication systems across languages reflect universal action constraints
Full text linkCorrection to: Nature Human Behaviour https://doi.org/10.1038/s41562-023-01697-4, published online 30 October 2023
Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in 11 adult intensive care units from 10 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)
Full text linkYalcin, Ata Nevzat/0000-0002-7243-7354; Dursun, Oguz/0000-0001-5482-3780; Leblebicioglu, Hakan/0000-0002-6033-8543; dursun, oguz/0000-0001-5482-3780; UNAL, SERHAT/0000-0003-1184-4711; Geyik, Mehmet Faruk/0000-0002-0906-0902; Topeli, Arzu/0000-0002-5874-9087WOS: 000316641000020PubMed: 23355330Purpose To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on the reduction of ventilator-associated pneumonia (VAP) in adult patients hospitalized in 11 intensive care units (ICUs), from 10 hospitals, members of the INICC, in 10 cities of Turkey. Methods A prospective active before-after surveillance study was conducted to determine the effect of the INICC multidimensional approach in the VAP rate. The study was divided into two phases. In phase 1, active prospective surveillance of VAP was conducted using the definitions of the Centers for Disease Control and Prevention National Health Safety Network, and the INICC methods. In phase 2, we implemented the multidimensional approach for VAP. The INICC multidimensional approach included the following measures: (1) bundle of infection control interventions, (2) education, (3) outcome surveillance, (4) process surveillance, (5) feedback of VAP rates, and (6) performance feedback of infection control practices. We compared the rates of VAP obtained in each phase. A time series analysis was performed to assess the impact of our approach. Results In phase 1, we recorded 2,376 mechanical ventilator (MV)-days, and in phase 2, after implementing the multidimensional approach, we recorded 28,181 MV-days. The rate of VAP was 31.14 per 1,000 MV-days during phase 1, and 16.82 per 1,000 MV-days during phase 2, amounting to a 46 % VAP rate reduction (RR, 0.54; 95 % CI, 0.42-0.7; P value, 0.0001.) Conclusions The INICC multidimensional approach was associated with a significant reduction in the VAP rate in these adult ICUs of Turkey.Foundation to Fight against Nosocomial InfectionsThe authors thank the many health care professionals at each member hospital who assisted with the conduct of surveillance in their hospital, including the surveillance nurses, clinical microbiology laboratory personnel, and the physicians and nurses providing care for the patients during the study; without their cooperation and generous assistance this INICC would not be possible; Mariano Vilar, Debora Lopez Burgardt, Santiago Suarez, Cecilia Cappelini, Denise Brito, Eugenia Manfredi, Luciana Soken, Dario Pizzuto, Yuan Ding, Katie Saunders, and Isaac Kelmeszes who work at INICC headquarters in Buenos Aires, for their hard work and commitment to achieve INICC goals; the INICC country coordinators (Altaf Ahmed, Carlos A. Alvarez Moreno, Anucha Apisarnthanarak, Luis E. Cuellar, Bijie Hu, Hakan Leblebicioglu, Eduardo A. Medeiros, Yatin Mehta, Lul Raka, Namita Jaggi, and Toshihiro Mitsuda); the INICC Advisory Board (Carla J. Alvarado, Gary L. French, Nicholas Graves, William R. Jarvis, Patricia Lynch, Dennis Maki, Russell N. Olmsted, Didier Pittet, Wing Hong Seto, Syed Sattar, and William Rutala), who have so generously supported this unique international infection control network; and specially to Patricia Lynch, who inspired and supported us to follow our dreams despite obstacles. The funding for the activities carried out at INICC head quarters were provided by the corresponding author, Victor D. Rosenthal, and Foundation to Fight against Nosocomial Infections
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