47 research outputs found
Strutton, J. (2011) The Tyranny of Grammar. Fishmarket Gallery, Northampton. 12 March – 20 April 2011.
No full textThe Tyranny of Grammar was a group exhibition exploring the work and legacy of the Northamptonshire vernacular poet John Clare. Part of this exhibition was ‘The Salon of the Vernacular’, which featured contemporary painting and works on paper by twenty two artists selected by John Strutton. As well as artworks in the gallery, there were events and talks, including a talk on Clare and the land by Professor John Goodridge, and a reading from the Author Alan Moore. For the artists in the Salon, landscape or place is returned to through the “detours” of myth, folklore, science fiction and personal narrative. The graphic is filtered through long lost allegiances and devotion to cultural icons of youthful protest and adoration. The figure is always particular and full of visual and stylistic idiosyncrasies, while acts of nostalgia are as much about revenge as they are sentiment. Even towering authorities such as modernism are recalled through compositions that owe as much to hand-painted shop signs as to considered geometric abstraction. The term “Salon” could not be more at odds with many of the values one associates with the vernacular, with its allusions to the academy and elite endorsement. The clustered and random connections conjured in this collection are more akin to the makeshift memorial or ex voto wall where each individual offering and heavily accented voice becomes part of a larger and less than melodic chorus invoking the late great Malcolm McLaren mantra to “live yesterday tomorrow!” Artists involved in the project were, Phillip Allen, Nathan Barlex, Lydia Corry, Graham Crowley, Stephen Dunne, Rhiannon Edwards, David Fletcher, Sara Gilies, Peter Harris, James Harrison, Lucy Harrison, Zoe Hodgson, Bibi Katholm, Ansel Krut, Simon Mathers, Chris Orr, David Rayson, George Shaw, John Strutton, Neal Tait, Milly Thompson, and Sam Windett
Atypical fibroxanthoma arising in a tracheostomy scar: A rare cicatricial neoplasm
No full textDear Editor,
Atypical fibroxanthoma (AFX) is a cutaneous neoplasm that classically occurs in heavily sun‐damaged skin on the head and neck of elderly patients.1 We report the case of a 70‐year‐old man who presented with a 1‐year history of a slowly enlarging, nodular lesion on his anterior neck (Fig. 1). The lesion was asymptomatic, apart from scant straw‐yellow discharge that had emanated from the lesion since its onset. The lesion was at the site of a scar from a tracheostomy, which was performed 40 years earlier following a motor vehicle accident. On examination, a nontender, flesh‐coloured nodule was found at the superior aspect of the scar, with a central pit and serous crusting. The lesion was mobile with deglutition due to cicatricial tethering to the trachea. A punch biopsy revealed a pleomorphic tumour with immunohistochemistry consistent with AFX, and the excision specimen supported this diagnosis (Fig. 2a–c).No Full Tex
Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases
No full textWe conducted a transcriptomic screen of osteosarcoma (OS) biopsies and found that expression of osteoclast-specific tartrate-resistant acid phosphatase 5 (ACP5/TRAP) is significantly downregulated in OS compared with nonmalignant bone (P < 0.0001). Moreover, lesions from OS patients with pulmonary metastases had 2-fold less ACP5/TRAP expression (P < 0.018) than lesions from patients without metastases. In addition, we found a direct correlation (P = 0.0166) between ACP5/TRAP expression and time to metastasis. Therefore, we examined whether metastasis-competent (MC) OS cells could induce loss of ACP5(+) osteoclasts and contribute to metastasis. We found that MC OS cell lines can inhibit osteoclastogenesis in vitro and in vivo. In addition, osteoclasts can inhibit the migration of MC OS cells in vitro. Finally, ablation of osteoclasts with zoledronic acid increases the number of metastatic lung lesions in an orthotopic OS model, whereas fulvestrant treatment increases osteoclast numbers and reduces metastatic lesions. These data indicate that the metastatic potential of OS is determined early in tumor development and that loss of osteoclasts in the primary lesion enhances OS metastasis.Liliana Endo-Munoz, Andrew Cumming, Danny Rickwood, Danielle Wilson, Claudia Cueva, Charlotte Ng, Geoffrey Strutton, A. Ian Cassady, Andreas Evdokiou, Scott Sommerville, Ian Dickinson, Alexander Guminski, and Nicholas A. Saunder
Skin surface topography grading is a valid measure of skin photoaging
No full textThe technique of grading the surface topography of sun-exposed skin using silicone impressions of the skin surface is a simple, non-invasive method for measuring skin damage because of sun exposure, but it has never been validated in a community setting
A rare pitfall in the molecular interpretation of BRAF V600E status in melanoma in the setting of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma
No full textBRAF mutation status is a critical predictive and prognostic biomarker in guiding management of unresectable and metastatic melanoma. We recently observed a case of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) intermixed with BRAF V600E wild-type melanoma reported to harbor BRAF V600E mutation on molecular testing. Our observation underscores the importance of appropriate tumor selection for molecular studies and knowledge of mutational status of co-existing tumors. This article is protected by copyright. All rights reserved
Bladder perivascular epithelioid cell tumour and tuberous sclerosis complex: a rare association
No full textExsanguination from an ulcerated, atypical, superficial venous malformation
No full textVenous malformations (VMs) are the most common vascular malformations, and their diagnosis can be challenging. They may develop in any region of the body, with highly variable clinical presentations. Although they typically present early in life, many case reports have documented the sudden appearance of a previously unrecognized venous malformation in adulthood. Pain is the major complaint in most of the cases, and other complications include phlebolith formation and bleeding. To our knowledge, fatal hemorrhage from a VM has not previously been reported in the medical literature. We present a case of exsanguination from a previously undiagnosed lower limb superficial VM. This case stresses the importance of proper diagnosis and management of VM
PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer
No full textThe non-canonical Wnt pathway, a regulator of cellular motility and morphology, is increasingly implicated in cancer metastasis. In a quantitative PCR array analysis of 84 Wnt pathway associated genes, both non-canonical and canonical pathways were activated in primary and metastatic tumors relative to normal prostate. Expression of the Wnt target gene PITX2 in a prostate cancer (PCa) bone metastasis was strikingly elevated over normal prostate (over 2,000-fold) and primary prostate cancer (over 200-fold). The elevation of PITX2 protein was also evident on tissue microarrays, with strong PITX2 immunostaining in PCa skeletal and, to a lesser degree, soft tissue metastases. PITX2 is associated with cell migration during normal tissue morphogenesis. In our studies, overexpression of individual PITX2A/B/C isoforms stimulated PC-3 PCa cell motility, with the PITX2A isoform imparting a specific motility advantage in the presence of non-canonical Wnt5a stimulation. Furthermore, PITX2 specific shRNA inhibited PC-3 cell migration toward bone cell derived chemoattractant. These experimental results support a pivotal role of PITX2A and non-canonical Wnt signaling in enhancement of PCa cell motility, suggest PITX2 involvement in homing of PCa to the skeleton, and are consistent with a role for PITX2 in PCa metastasis to soft and bone tissues. Our findings, which significantly expand previous evidence that PITX2 is associated with risk of PCa biochemical recurrence, indicate that variation in PITX2 expression accompanies and may promote prostate tumor progression and metastasis
