3,692 research outputs found
Tradurre per comprendere. Gobetti tra Croce e Gentile
No full textStudio comparato degli scritti di Gobetti, Gentile e Croce sulla critica e teoria della traduzione
La questione del signe saussuriano nella Scuola linguistica romana
No full textL’articolo si propone di indagare la ricezione della nozione di segno di Ferdinand de Saussure in Italia in séguito alla pubblicazione del Cours de linguistique générale. All’interno di questa prospettiva Mario Lucidi e Walter Belardi ebbero un ruolo pioneristico nella diffusione e nell’esegesi della teoresi di Saussure, oggetto di studio privilegiato nella storiografia linguistica. Lucidi e Belardi reinterpretarono, infatti, il signe saussuriano come “segno-frase” alla luce degli insegnamenti del loro comune maestro Antonino Pagliaro. In ultima analisi, l’articolo prende in esame la relazione fra l’opera di Saussure e la teoria sviluppata da Lucidi e Belardi.This paper aims at investigating the reception of Ferdinand de Saussure’s definition of linguistic sign in Italy after the publication of the Cours de linguistique générale. On this matter, Mario Lucidi and Walter Belardi have played a prominent role in the dissemination and criticism of the theory proposed by Saussure, which heated a lively debate among scholars. Indeed, according to their mentor Antonino Pagliaro’s teachings, Lucidi and Belardi have revisited the Saussurean sign and provided a new definition of linguistic sign as “utterance-sign”. Therefore, the paper deals with the relationship between Saussure’s work and the theory developed by Lucidi and Belardi
La missione educativa di Anna Vertua Gentile e Simone Weil: un filosofare scomodo
No full textThe contribution aims to provide an analysis of the intellectual positioning of two thinkers who, through their lucid pedagogical-theoretical reflection, illuminated the darkness of the 19th century: Anna Vertua Gentile and Simone Weil. From Galatei's proposal to the Epistles emerges the identity of being a teacher as a living metaphor of a witness education, of an uncomfortable educational philosophy
Systematic review of platelet-rich plasma use in androgenetic alopecia compared with minoxidil®, finasteride®, and adult stem cell-based therapy
No full textThe number of articles evaluating platelet-rich plasma (PRP) efficacy in androgenic alopecia (AGA) have exponentially increased during the last decade. A systematic review on this field was performed by assessing in the selected studies the local injections of PRP compared to any control for AGA. The protocol was developed in accordance with the Preferred Reporting for Items for Systematic Reviews and Meta-Analyses-Protocols (PRISMA-P) guidelines. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases was performed to identify studies on hair loss treatment with platelet-rich plasma. Of the 163 articles initially identified, 123 articles focusing on AGA were selected and, consequently, only 12 clinical trials were analyzed. The studies included had to match predetermined criteria according to the PICOS (patients, intervention, comparator, outcomes, and study design) approach. In total, 84% of the studies reported a positive effect of PRP for AGA treatment. Among them, 50% of the studies demonstrated a statistically significant improvement using objective measures and 34% of the studies showed hair density and hair thickness improvement, although no p values or statistical analysis was described. In total, 17% of the studies reported greater improvement in lower-grade AGA, while 8% noted increased improvement in higher-grade AGA. Only 17% of the studies reported that PRP was not effective in treating AGA. The information analyzed highlights the positive effects of PRP on AGA, without major side effects and thus it be may considered as a safe and effective alternative procedure to treat hair loss compared with Minoxidil® and Finasteride®
Rozpor ako východisko, láska ako smer u Simone Weilovej (Contradiction as base, Love as direction in writings of Simone Weil)
No full textArticle is explaining contradiction and love, Simone Weil‘s essential terms of hermeneutics of human Being. It introduces close relation of these terms with her understanding of God as well as with her overall concept of religion. Author also mentions Simone Weil‘s inspirations with philosophical and spiritual concepts of the East
Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development
No full textThe use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation)
Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair
No full textAdipose-derived stem cells (ASCs) have been routinely used from several years in regenerative surgery without any definitive statement about their potential pro-oncogenic or anti-oncogenic role. ASCs has proven to favor tumor progression in several experimental cancer models, playing a central role in regulating tumor invasiveness and metastatic potential through several mechanisms, such as the paracrine release of exosomes containing pro-oncogenic molecules and the induction of epithelial-mesenchymal transition. However, the high secretory activity and the preferential tumor-targeting make also ASCs a potentially suitable vehicle for delivery of new anti-cancer molecules in tumor microenvironment. Nanotechnologies, viral vectors, drug-loaded exosomes, and micro-RNAs (MiR) represent additional new tools that can be applied for cell-mediated drug delivery in a tumor microenvironment. Recent studies revealed that the MiR play important roles in paracrine actions on adipose-resident macrophages, and their dysregulation has been implicated in the pathogenesis of obesity, diabetes, and diabetic complications as wounds. Numerous MiR are present in adipose tissues, actively participating in the regulation of adipogenesis, adipokine secretion, inflammation, and inter-cellular communications in the local tissues. These results provide important insights into Adipocyte-secreted exosomal microRNA (A-SE-MiR) function and they suggest evaluating the potential role of A-SE-MiR in tumor progression, the mechanisms underlying ASCs-cancer cell interplay and clinical safety of ASCs-based therapies
“I beg you to tell me what has become of Djamila”: The Political Mobilization of Simone de Beauvoir’s Readers During the Boupacha Affair
No full textBy Sophia Millman This is a condensed version of a Masters thesis dedicated to the political mobilization of Simone de Beauvoir’s readers. The citations from the letters were translated from French by the author. *** On June 2, 1960, the French government ordered all copies of the daily Algiers edition of Le Monde seized and destroyed to suppress the publication of Simone de Beauvoir’s article “Pour Djamila Boupacha.” Beauvoir, a self-professed “woman of letters”, not “of action[1]”, and one ..
La nozione di (protero)semema di Belardi. Un capitolo (poco noto) di storia del pensiero linguistico
No full textIl contributo intende presentare la nozione di (protero)semema elaborata da Walter Belardi all’interno della sua teoria del segno. La riflessione di Belardi intorno alla tipologia della struttura formale della parola, sviluppata a partire dagli insegnamenti, soprattutto orali, di Antonino Pagliaro, e dalle considerazioni di Mario Lucidi si inserisce in una più ampia discussione sul segno linguistico cui presero parte anche Émile Benveniste e André Martinet
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