1,722,584 research outputs found
Use of blockchain technology for smart health-care services: a critical perspective of ethnic minority group
No full textPurposeThe essence of blockchain governance is a far departure from the cryptocurrency or Bitcoin that has led to innovation and changing the outline of medical services. The major challenge in medical services is the lack of accessibility of medical services and lack of awareness. A large group of the population belonging to an ethnic minority has a high rate of complications, re-operation and graft rejection. To connect with a minority group and address privacy and safety issues, blockchain-based e-health-care services have massive potential in the medical industry, especially from the perspective of the social aspect.Design/methodology/approachThe study proposed a framework that describes the complex interplay of different stated factors, including perceived ease of use, trust, perceived usefulness and perceived security and privacy. The paper uses structural equation modeling to understand the ethnic minority group’s readiness to adopt blockchain-based e-health-care services.FindingsIt was found that all the direct relationships between variables are supported by the findings and have a significant positive relationship with the adoption intention. The tested framework will help regulatory bodies and marketers to develop support health-care service mechanisms for ethnic minority groups by addressing their issues related to security and privacy.Originality/valueBlockchain-based e-health-care services have massive potential in the medical industry, although, its actual diffusion has not been explored much, with particular reference to an ethnic minority group. This study will explore the diffusion of smart health-care services with respect to ethnic minority group
Does the world need to change its vaccine distribution strategy for COVID-19?
No full textDuring an emergency, there are many activities in a pharmaceutical supply chain (PSC) which are rendered ineffective. This study aims to propose a holistic approach for Big Data Driven Pharmaceuticals Supply Chain (BDDPSC) during medical emergencies. During unprecedented situations, the quality of healthcare services by using traditional supply chain becomes a challenge. The current study aims to generate a model wherein multiple entities will be the part of data entries like hospitals, clinical trials, medical practitioners, and drug manufacturing companies during COVID-19. The study has considered certified medical practitioners as the experts and based their responses for proposing a theoretical framework deploying E-Delphi–Qualitative Data Analysis approach. By critically examining experts’ responses and comments, the study formulated four major themes and ten sub-themes for smooth functioning of BDDPSCs during an emergency. The E-Delphi was conducted in two rounds to reach final consensus and to find a balance for PSC in terms of efficiency and quality. This research is novel wherein big data enabled PSC theoretical model has been formulated using a qualitative approach for handling COVID-19. The proposed framework provides an enriched way to capture data from the important link viz. “health officials” of PSCs
Lectotypification of four names in the genus Smilax (Smilacaceae)
No full textSukhramani, Geetika, Choudhary, Ritesh Kumar (2022): Lectotypification of four names in the genus Smilax (Smilacaceae). Phytotaxa 532 (1): 107-113, DOI: 10.11646/phytotaxa.532.1.1
Silica-coated magnetic nanoparticles impair proteasome activity and increase the formation of cytoplasmic inclusion bodies in vitro
No full textThe potential toxicity of nanoparticles, particularly to neurons, is a major concern. In this study, I assessed the cytotoxicity of silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate dye (MNPs@SiO2(RITC)) in HEK293 cells, SH-SY5Y cells, and rat primary cortical and dopaminergic neurons. In cells treated with 1.0 µg/µl MNPs@SiO2(RITC), the expression of several genes related to the proteasome pathway was altered, and proteasome activity was significantly reduced, compared with control and with 0.1 µg/µl MNPs@SiO2(RITC)-treated cells. Due to the reduction of proteasome activity, formation of cytoplasmic inclusions increased significantly in HEK293 cells over-expressing the α–synuclein interacting protein synphilin-1 as well as in primary cortical and dopaminergic neurons. Primary neurons, particularly dopaminergic neurons, were more vulnerable to MNPs@SiO2(RITC) than SH-SY5Y cells. Cellular polyamine metabolism related enzymes, which are associated with protein aggregation, were significantly altered in SH-SY5Y cells treated with MNPs@SiO2(RITC). These findings highlight the mechanisms of neurotoxicity incurred by nanoparticles.A. INTRODUCTION 1
B. RESULTS
1) Clathrinmediated endocytosis related genes are altered in MNPs@SiO2(RITC) treated HEK293 cells 8
2) MNPs@SiO2(RITC) disturb the expression pattern of proteasome related genes in HEK 293 cells 10
3) MNPs@SiO2(RITC) facilitate formation of inclusion bodies in Synphilin1 stably overexpressed 293 (Synph293) cells 13
4) MNPs@SiO2(RITC) cause disturbance in proteasome activity of primary neuronal cells 17
5) MNPs@SiO2(RITC) facilitate the formation of inclusion bodies in SHSY5Y cells and primary neuronal cells 19
6) Nanoparticles induce mild Endoplasmic Reticulum (ER) stress in HEK293 cells 25
7) MNPs@SiO2(RITC) induce ROS generation and cell death in primary neurons 27
8) MNPs@SiO2(RITC) alter polyamine metabolism in SHSY5Y cells 31
C. DISCUSSION 33
D. MATERIALS AND METHODS
a) Cell culture 39
b) Primary neuronal culture 39
c) MNPs@SiO2(RITC) and silica nanoparticles 41
d) RNA purification 41
e) Quantitative realtime PCR (qPCR) and reverse transcription PCR (RTPCR) 42
f) Proteasome activity assay 47
g) MTS assay 48
h) Immunocytochemistry 48
i) ROS measurement in neuronal cells 51
j) Western blotting 51
k) Statistical analysis 52
E. REFERENCES 53Docto
FIGURE 2 in Lectotypification of four names in the genus Smilax (Smilacaceae)
No full textFIGURE 2. Lectotype of Smilax kingii J.D.Hooker K000292116 © copyright of the Board of Trustees of the Royal Botanic Gardens, Kew.Published as part of Sukhramani, Geetika & Choudhary, Ritesh Kumar, 2022, Lectotypification of four names in the genus Smilax (Smilacaceae), pp. 107-113 in Phytotaxa 532 (1) on page 109, DOI: 10.11646/phytotaxa.532.1.10, http://zenodo.org/record/590079
TDO882529 Supplemetal Material - Supplemental material for Koebner phenomenon induced by Mantoux testing in a case of papulonecrotic tuberculid
No full textSupplemental material, TDO882529 Supplemetal Material for Koebner phenomenon induced by Mantoux testing in a case of papulonecrotic tuberculid by Geetika Chhabra, Prashant Verma and Shruti Sharma in Tropical Doctor</p
A Systematic Review of Contactless Technologies Research in Hospitality and Tourism During the COVID-Pandemic
Full text linkSince the onset of the COVID-19 pandemic, the implementation of contactless technologies in hospitality and tourism has grown exponentially, making understanding consumer adoption of these technologies an important research area. A systematic literature review of relevant studies published in hospitality and tourism journals was conducted to identify three main subsets of the antecedents of contactless technologies adoption: system, user, and the environment. An analysis of 44 peer-reviewed articles from top hospitality and tourism journals is presented, along with an identification of 10 main categories of contactless technology. Findings indicate the specific technologies adopted since the onset of the COVID-19 pandemic and the common factors studied related to contactless technologies in past research. Theoretical/managerial implications and directions for future research are discussed
Circular Economy and Re-Commerce in the Fashion Industry
No full textThe apparel industry has the scale, reach, and technical expertise to deliver on-target sustainable development goals within the industry’s sphere of influence in its interconnected global and local value chains. From the farm to the consumer, the textile, retail, and apparel production industry has an array of economic, environmental, social, and governance impacts. In order to meet sustainable goals, the industry is challenged to buy and produce goods and services that do not harm the environment, society, and the economy.Circular Economy and Re-Commerce in the Fashion Industry is a pivotal reference source that explores and proposes solutions for best practices to meet sustainable development goals in the fashion industry and provides guidelines for assessing the technological landscape and modeling sustainable business practices. Highlighting a wide range of topics including digital marking, consumer behavior, and social and legal perspectives, this book is ideally designed for suppliers, brand managers, retailers, multinational investors, marketers, executives, designers, manufacturers, policymakers, researchers, academicians, and students
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