33,001 research outputs found
Pharmacological characterization of excitatory synaptic potentials in rat basolateral amygdaloid neurons
No full textEpileptiform activity involved by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors
No full textThe involvement of metabotropic glutamate receptors in long-term depression of N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus
No full textActivation of metabotropic glutamate receptors in conjunction with postsynaptic depolarization triggers a long-term depression of the N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus
No full textLong-term enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala
No full textFaith in Wu Po and Social Vicissitudes of Guilin Area
No full text运用历史人类学方法探讨了桂林地区武婆信仰的起源、发展和衰落的过程,纠正了以往研究的一些错误结论。并着重分析了宋、明两次打击武婆事件的经过,指出其实质是国家正统力量与地方性知识的博弈。武婆信仰的命运反射的是一个区域的历史进程。In this article,the author discusses about the origin,development and decline of faith in Wu Po in Guilin,correcting wrong conclusions in previous studies.Stress is laid on the analysis of the two suppressions of Wu Po in the Song and Ming dynasties;then its pointed out that they are essentially a comparison of strength between the government force and local knowledge.The vicissitudes of Wu Po are a mirror of the history of the Guilin area.广西民族大学少数民族艺术硕士点经费资
Abstract 5103: Development of MJ-66 as a novel anticancer agent for the treatment of malignant gliomas
No full textAbstract
Malignant glioma is the most common aggressive adult primary tumor of the central nervous system. Treatments of malignant gliomas include surgery, radiotherapy and adjuvant temozolomide (TMZ) chemotherapy. However, inherent- and acquired resistance to TMZ present major obstacles to successful treatment, and the prognosis of patients with malignant gliomas remains very poor.
MJ-66, a synthetic qunazoline compound, was identified in our study as a potent anti-proliferative agent especially on human glioma with IC50 of approximately 60 nM. In intracranial glioma xenograft model, MJ-66 (0.14 mg/kg in saline, i.p., q.d., 10 days) significantly inhibited tumor growth and increased the survival of the experimental mice, however, did not decrease the body weight of mice.
Currently, there is a profound unmet medical need for a new drug in the treatment of malignant brain tumor. The MJ-66 demonstrated superior efficacy to TMZ that are the only first-line-drug in clinical use. MJ-66 is suggested to be a promising anticancer candidate.
Note: This abstract was not presented at the meeting.
Citation Format: Mann-Jen Hour, Tai-Lin Chen, Po-Wu Gean, Hong-Zin Lee. Development of MJ-66 as a novel anticancer agent for the treatment of malignant gliomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5103. doi:10.1158/1538-7445.AM2017-5103</jats:p
Control and Filtering for Discrete Linear Repetitive Processes with H infty and ell 2--ell infty Performance
No full textRepetitive processes are characterized by a series of sweeps, termed passes, through a set of dynamics defined over a finite duration known as the pass length. On each pass an output, termed the pass profile, is produced which acts as a forcing function on, and hence contributes to, the dynamics of the next pass profile. This can lead to oscillations which increase in amplitude in the pass to pass direction and cannot be controlled by standard control laws. Here we give new results on the design of physically based control laws for the sub-class of so-called discrete linear repetitive processes which arise in applications areas such as iterative learning control. The main contribution is to show how control law design can be undertaken within the framework of a general robust filtering problem with guaranteed levels of performance. In particular, we develop algorithms for the design of an H? and dynamic output feedback controller and filter which guarantees that the resulting controlled (filtering error) process, respectively, is stable along the pass and has prescribed disturbance attenuation performance as measured by and – norms
Penser l’hégémonie dans le monde contemporain
No full textIs There a Possible Dialogue Between Hegemony and Cosmopolitanism? Interview with Frédéric Ramel -- What do the two concepts of hegemony and cosmopolitanism imply? Are they opposed or is there a possible dialogue between them? In a recently published chapter (“Competition for Hegemony ” in the edited volume Cosmopolitanism in Hard Times), Professor of political science at Sciences Po CERI Frédéric Ramel questions these concepts and explores their scope. The following is an interview with the author. Interview by Miriam Perier, CERI
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