198,968 research outputs found
Caracterització dels tipus d'activació de diferents poblacions de macròfags durant la pancreatitis aguda experimental i la seva relació amb la severitat del procés
No full textMalgrat els esforços dedicats a investigar la pancreatitis aguda (PA), segueixen sense resposta la major part de les preguntes plantejades fa anys. En particular, encara no es coneixen tots els mecanismes pels que una lesió localitzada en el pàncrees pot induir una afecció en òrgans distants, com el pulmó.
Durant els últims anys s’ha pogut establir que l’activació de les cèl•lules inflamatòries juga un paper central en el desenvolupament d’aquesta malaltia.
Per una altra banda, els macròfags poden presentar diferents fenotips en funció del tipus d’activació a la que es veuen sotmesos, destacant l’activació clàssica (induïda per INFγ) i l’alternativa (induïda per citocines com IL4, IL13, IL10, glucocorticoids..). Aquests tipus d’activació podrien condicionar la progressió de la pancreatitis cap a formes lleus o severes.
En aquesta tesi s’ha avaluat el tipus d’activació que presenten diferents poblacions de macròfags i la seva relació amb la severitat del procés (lleu, moderada o severa). El treball s’ha realitzat a nivell experimental in vivo, utilitzant un model de PA per infusió de sals biliars. També s’ha analitzat la resposta de les diferents poblacions de macròfags als estímuls generats durant la pancreatitis i s’ha treballat sobre aquests macròfags amb la finalitat de modificar la via d’activació que presenten i ,amb això, modular el procés inflamatori sistèmic associat a la PA.
La hipòtesi de partida és que el tipus d’activació de les diferents poblacions de macròfags implicats en la pancreatitis aguda condiciona l’evolució i la severitat de la malaltia. Actuant sobre el tipus d’activació de diferents poblacions de macròfags es podria modificar el curs de la malaltia de severa a lleu.
Així doncs els objectius concrets d’aquest treball serien:
1. Obtenir i caracteritzar el tipus d’activació presentat per els macròfags peritoneals i pulmonars durant el desenvolupament de la pancreatitis aguda. Correlacionar el tipus d’activació de les diferents poblacions de macròfags amb el grau de severitat de la patologia.
2. Avaluar el paper de les diferents vies de senyalització intracel•lular implicades en el fenotip dels macròfags.
3. Determinar els possibles mediadors implicats en l’activació dels macròfags durant la pancreatitis aguda
Modeling and Evaluation of Multisource Streaming Strategies in P2P VoD Systems
No full textIn recent years, multimedia content distribution has largely been moved to the Internet, inducing broadcasters, operators and service providers to upgrade with large expenses their infrastructures. In this context, streaming solutions that rely on user devices such as set-top boxes (STBs) to offload dedicated streaming servers are particularly appropriate. In these systems, contents are usually replicated and scattered over the network established by STBs placed at users' home, and the video-on-demand (VoD) service is provisioned through streaming sessions established among neighboring STBs following a Peer-to-Peer fashion. Up to now the majority of research works have focused on the design and optimization of content replicas mechanisms to minimize server costs. The optimization of replicas mechanisms has been typically performed either considering very crude system performance indicators or analyzing asymptotic behavior. In this work, instead, we propose an analytical model that complements previous works providing fairly accurate predictions of system performance (i.e., blocking probability). Our model turns out to be a highly scalable, flexible, and extensible tool that may be helpful both for designers and developers to efficiently predict the effect of system design choices in large scale STB-VoD system
Environmental Impact Assessment Permanent Campus Universiti Malaysia Sarawak Kota Sarawak
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Phase 1b/2 study of margetuximab (M) plus pembrolizumab (P) in advanced HER2+ gastroesophageal junction (GEJ) or gastric (G) adenocarcinoma (GEA)
No full text140 Background: Trastuzumab (T) + chemotherapy (ctx) is standard for 1st line advanced HER2+ GEA, yet subsequent targeted options are lacking. M is an anti-Her 2 monoclonal antibody with an optimized Fc domain to increase affinity for activating CD16A Fc-receptors (FcR) on NK cells. Outcomes for T-treated patients (pts) carrying the low-affinity CD16A-F allele are generally worse than pts homozygous for the high-affinity V allele. M is designed to be FcR genotype independent. Evidence of clinical activity of M alone has been seen in HER2+ GEA pts post T, while P has demonstrated durable activity. Loss of HER2 amplification may occur after T failure in a subset of initially HER2+ GEA pts. Preclinical studies suggest that engagement of innate and adaptive immunity with the combination of anti-HER-2 antibodies and T-cell checkpoint inhibition could achieve greater antitumor activity than either agent alone. Methods: Advanced HER2+, PD-L1-unselected GEA pts post T failure were eligible. Dose escalation evaluated 10 and 15 mg/kg M and 200 mg P for 2nd line or higher pts. Cohort expansion evaluates safety and objective response rate (ORR) by RECIST v1.1 in 2nd line pts. M + P is given every 21 days; response assessed every 6 weeks. HER2 amplification status was assessed in a subset of pts by plasma circulating tumor (ct) DNA analysis prior to Cycle 1 of M+P. Results: Dose escalation enrolled 9 pts; cohort expansion 48 pts at 15 mg/kg M: 30 in North America (NA) and 18 in Asia (A). Treatment was well tolerated, with 1 drug-related serious adverse event. Of 38 evaluable pts to date in expansion (24 NA and 14 A), the best overall responses include 7 pts (18.4%) with PR (4 confirmed and 3 unconfirmed) and 11 (28.9%) with SD. Higher ORR trends were observed in A vs NA (35.7% vs 8.3%) and G vs GEJ (31.6% vs 5.3%). Of 25 pts with ctDNA results, HER2 amplification detection was higher in GC than GEJ (80% vs 53%). Responses were independent of FcR genotype; CD16A genotype for evaluable pts with PR: 1 V/V, 2 V/F, 2 F/F with similar allelic distribution among non-responders. Conclusions: M+P is a well-tolerated ctx-free regimen that has shown preliminary antitumor activity in 2nd line pts with advanced/metastatic GEA. Clinical trial information: NCT02689284
Legionelosis en España, 2010-2015
No full textIntroduction: Legionellosis is a bacterial respiratory disease with an environmental origin in the community or in hospitals; it is usually associated with devices, facilities, and buildings. The most common clinical form is the pneumonic, known as legionnaires’ disease.Objective: To determine the evolution of legionellosis cases in Spain from 2010 to 2015. Materials and methods: This was a descriptive study of time series with an analysis of the legionellosis cases notified to the Centro Nacional de Epidemiología (Government of Spain). Case distribution was determined according to sex, the autonomous community of origin, month, and age groups differentiating in the latter between men and women. Results: Case count in men was more than double compared to that in women. The cases notified by nine of the autonomous communities showed an increase at the end of the period, especially in Castilla y León, Navarra, and the Basque Country but also notable in Castilla-La Mancha. A seasonal pattern was identified with an epidemic peak in July-September and a greater number of cases among 50-years old people from both sexes.Conclusion: Despite its low prevalence compared to other respiratory diseases, legionellosis has a great impact on public health. Its distribution in Spain is global and heterogeneous with cases increasing in the last two years. Therefore, better disease prevention and control measures are recommended.Introducción. La legionelosis es una enfermedad respiratoria bacteriana de origen ambiental que puede ser adquirida en el ámbito comunitario u hospitalario, y suele estar asociada con equipos, instalaciones y edificios. La forma clínica más conocida es la neumónica, conocida como enfermedad del legionario.Objetivo. Determinar la evolución de los casos de legionelosis en España en el periodo de 2010 a 2015.Materiales y métodos. Se hizo un estudio descriptivo de series temporales y se analizaron los casos de legionelosis notificados al Centro Nacional de Epidemiología del Gobierno de España. Se determinó la distribución de los casos según el sexo, la comunidad autónoma, el mes y los grupos de edad. Para el último se diferenció entre hombres y mujeres.Resultados. El recuento de casos en hombres fue superior al doble con respecto a las mujeres. La distribución en las comunidades autónomas presentó un aumento de los casos notificados al final del periodo en nueve de ellas, siendo notable en Castilla y León, Navarra y el País Vasco, y muy relevante en Castilla-La Mancha. Se estableció un patrón estacional con un pico epidémico en julio-septiembre y un mayor número de casos en torno a los 50 años de edad en ambos sexos.Conclusiones. A pesar de mostrar una prevalencia baja con respecto a otras enfermedades respiratorias, la legionelosis tiene gran impacto en la salud pública. Presenta una distribución global y heterogénea en el territorio español, con un aumento de casos en los dos últimos años
ESPAI GEA: A new platform for promoting Geology in Catalonia
No full textX Congreso Geológico de España, 5-7 Julio 2021, Vitoria - GasteizESPAI GEA es una comunidad abierta que nace con el objetivo de promover las Ciencias de la Tierra y divulgar la importancia del conocimiento geológico entre la ciudadanía. La voluntad de ESPAI GEA es la de conectar a todas las instituciones, asociaciones, entidades, museos, centros de interpretación, etc., que realizan actividades relacionadas con las Ciencias de la Tierra y la Geología en el territorio catalán.
La primera acción que se está llevando a cabo desde ESPAI GEA es la de crear una agenda con el objetivo de centralizar las actividades de divulgación en una única plataforma que sirva al mismo tiempo de escaparate y altavoz. Con estas premisas se está implementando la agenda en un visor web, en el que se mostrarán principalmente dos tipos de información: i) por una parte, actividades y eventos de carácter temporal, y ii) por otra parte, la geolocalización de información geológica disponible permanentemente (paneles informativos, itinerarios geológicos, área geográfica de las guías publicadas, centros de interpretación, museos, centros de investigación, u otras instalaciones singulares relacionadas) así como otra información de interés complementaria.
ESPAI GEA también quiere incidir de una manera muy especial en la comunidad educativa, realizando actividades formativas, proporcionando recursos didácticos y favoreciendo la actualización científica del profesorado.ESPAI GEA is an open community that is born with the aim of promoting Earth Sciences and to disseminate the importance of geological knowledge among citizens. The goal of ESPAI GEA is to connect all the institutions, associations, entities, museums, interpretation centres, etc., that carry out activities related to Earth Sciences and Geology in the Catalan territory.
The first action undertaken within ESPAI GEA is to create an agenda to assemble all the dissemination activities in a common platform that works both as a showcase and as amplifier of the activities. Under these premises, the agenda is being implemented into a web viewer, this will display two main types of data; i) on the one hand, temporary activities and events, and ii) on the other hand, the location of existing permanent geological data (information boards, geological itineraries, geographical areas of published guides, interpretation centres, museums, research centres, etc.) along with other information.
ESPAI GEA wants to pay special attention to the educational community, carrying out training activities, providing instructional resources and promoting continuing education in Geology for teacher community.Peer reviewe
GEA-R7: redes, territórios e novos olhares estéticos
No full textThe aim of this article is presenting the reader how a networking strategy that has allowed to keep alive two groups over time, through interaction of technological media that overcome the body’s barrier. For this, the aim is to recognize the fundamental concepts that give shape to this interaction and are: the territory, the soro-rity and the network configuration. Subsequently, a brief account of the organizations and way of working will be given, to finalize by relating some of the experiences of the participants of the organizations of GEA and R7, their feeling, thinking, recognizing their voices on working with the organizations.Este artículo tiene como objetivo dar a conocer al lector una estrategia de trabajo en red y formativa, que ha permitido la continuidad de dos colectivos en el tiempo, mediante la interacción con medios tecnológicos que superan la barrera del cuerpo. Para ello se pretende reconocer los conceptos fundamentales que dan forma a dicha interacción y son: el territorio, la sororidad y la configuración de red. Posteriormente, se dará un breve recuento de las organizaciones y la forma de trabajo, para al final relacionar algunas de las experiencias de los participantes de las organizaciones de GEA y R7, su sentir pensar, reconociendo sus voces sobre el trabajo con las organizaciones.Este artigo tem como objetivo definir um parceiro para uma estratégia de trabalho em vermelho e formativo que tenha permitido a continuidade de grupos no tempo, a partir da interação com os meios tecnológicos que supe-ram a barreira do cuerpo. Para definir se deseja reconec-tar os conceitos fundamentais que formam e interagem com o filho: o território, a irmandade e a configuração do vermelho. Posteriormente, selecione um breve retorno das organizações e forma de trabalho, para relacionar as algas com as experiências dos participantes das organi-zações de GEA e R7, no sentido de pensar, reconectando os vocais sobre a organização com as organizações
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
The GEA pipeline for characterizing Escherichia coli and Salmonella genomes
No full textAbstract Salmonella enterica and Escherichia coli are major food-borne human pathogens, and their genomes are routinely sequenced for clinical surveillance. Computational pipelines designed for analyzing pathogen genomes should both utilize the most current information from annotation databases and increase the coverage of these databases over time. We report the development of the GEA pipeline to analyze large batches of E. coli and S. enterica genomes. The GEA pipeline takes as input paired Illumina raw reads files which are then assembled followed by annotation. Alternatively, assemblies can be provided as input and directly annotated. The pipeline provides predictive genome annotations for E. coli and S. enterica with a focus on the Center for Genomic Epidemiology tools. Annotation results are provided as a tab delimited text file. The GEA pipeline is designed for large-scale E. coli and S. enterica genome assembly and characterization using the Center for Genomic Epidemiology command-line tools and high-performance computing. Large scale annotation is demonstrated by an analysis of more than 14,000 Salmonella genome assemblies. Testing the GEA pipeline on E. coli raw reads demonstrates reproducibility across multiple compute environments and computational usage is optimized on high performance computers
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
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