1,720,969 research outputs found
The role of multidisciplinary approach in the clinical management of differentiated thyroid cancer
No full textThyroid cancer is, in general, the most frequent endocrinological neoplasm, characterized however by an extremely low mortality rate, morbidity and persistence of disease. This is due in part to the often indolent nature of the disease, but also to the ever increasing appropriateness of primary treatments, often capable of eradicating the disease in the face of low burdens of adverse events.
The availability of increasingly targeted approaches to the specific condition of the individual patient makes it necessary for shared management among the various specialist figures involved in the treatment of the pathology. During the PhD course, some of the issues relating to multidisciplinary management and the integration of skills in the diagnostic-therapeutic pathway of thyroid cancer were studied, from the initial stages to the treatment of advanced disease.
After the diagnosis, the surgical approach represents the first line of treatment of the disease. Over the last few years, the use of increasingly less invasive techniques has made it possible to reduce adverse events and complications. However, this must be based on a correct classification and estimation of the risk of recurrence. In particular, papillary microcarcinoma (mPTC) has demonstrated a particularly indolent behavior and a minimal recurrence rate. In this sense, we evaluated a cohort of patients affected by mPTC and studied the factors that could predict its recurrence and therefore be considered in the treatment definition.
Following surgery, the need for radioiodine therapy (RAI), aimed at identifying and selectively targeting any residual thyroid tissue, must also be evaluated on the basis of the characteristics of the surgically removed disease and the available clinical and biochemical parameters post-surgery. Close cooperation between the endocrinologist, pathologist and nuclear doctor is therefore mandatory. From this point of view, we considered the impact of minimal extrathyroidal extension (understood as microscopic invasion beyond the organ capsule) of differentiated thyroid cancer (DTC) on the risk of recurrence, finding that this does not significantly change the risk of recurrence.
Another retrospective study was also conducted in order to compare the efficacy and adverse events of RAI performed at standard doses with that at low doses. The latter, now widely approved in patients at low and sometimes intermediate risk of recurrence, has confirmed excellent efficacy data, showing a slightly superior clinical tolerability profile and no significant changes from the haematochemical point of view compared to the standard treatment.
An important aspect in the management of patients with thyroid cancer, given the excellent response rate to primary treatments, is represented by the long-term follow-up and the prevention of complications, from an endocrine point of view but above all from a cardiovascular point of view. In this sense, in addition to investigating the association between thyroid cancer and other endocrine pathologies such as hyperparathyroidism, which has demonstrated an independent impact on the patient's prognosis, we evaluated the incidence and possible predictive factors of cardiovascular events in a DTC population with at least 5 years of follow-up, confirming the role of careful cardiovascular evaluation, especially in patients maintained in TSH suppression.
Furthermore, the incidence of vascular events, specifically those of a thromboembolic nature (TEE), was also studied in the context of advanced and iodine-refractory thyroid cancer, initially in a small cohort of patients receiving tyrosine inhibitor therapy. kinase, thus evaluating the possible predictive factors of TEE within a court of patients affected by advanced cancer.
Finally, with regard to the treatment of advanced and iodine-refractory thyroid cancer, the cooperation of diversified professional figures appears essential, given the great development in this context of target-therapies aimed at the specific typology and mutational profile of the disease. In this regard, a limited case series of patients subjected to mutational and immunohistochemical analysis was retrospectively analysed, confirming the importance of the BRAF, TERT genes and PDL1 expression in defining the prognostic picture and possible therapeutic approaches. Also for these patients, the comparison between the endocrinologist and the nuclear doctor is necessary in order to integrate conventional radiology data with information deriving from functional imaging such as PET with FDG, in order to study the initial prognosis, the progress of the disease and the response to different treatment regimens
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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