1,720,975 research outputs found
Has IL2 a role in the management of minimal residual disease for acute leukemia?
No full textBased on pre-clinical findings and on more recent preliminary in vivo data it has been suggested that immunotherapy with Interleukin 2 (IL2) may be employed in the treatment of acute leukemia patients. Here we shall discuss the biological and clinical observations which indicate that this innovative therapeutic approach may play a role in the management of minimal residual disease
Modifications of cellular oncogenes and MHC Class II genes expression during in vitro differentiation of human hemopoietic cell lines
No full textTreatment of acute myeloid leukaemia patients with recombinant interleukin 2: a pilot study.
No full textIL-2 in the treatment of chronic myeloid leukemia after lymphoid blast crisis: a pilot study
No full textFive patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and at the lower doses as outpatients. Concerning the therapeutic efficacy, our preliminary results indicate that IL2 might be useful in enhancing the chemosensitivity of the leukemic blasts. It remains to be seen if this will result in a rapid return of the CP and in a prolongation of survival
Ontogeny, gene rearrangements and immunophenotype of acute leukaemias
No full textThe progressive availability of more sophisticated technologies has over the last few years allowed a more precise definition of the biological properties of acute leukaemia cells. This, in turn, has enabled to recognize the ontogeny of practically all cases, with particular emphasis to acute lymphoblastic leukaemia, the lineage affiliation of which had, for many years remained uncertain in over half of the cases. Here, we shall review the main achievements, obtained with extensive immunotyping coupled to the use of probes for the immunoglobulin and T-cell receptor genes, which have led to these important clinico-biological acquisitions, and discuss specific situations in which this combined phenotypic and genotypic approach (as well as response to cloned growth factors) may be of particular value
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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