72 research outputs found
Advances in PGPR research/ edited by Harikesh Bahadur Singh, Banaras Hindu University, India, Birinchi Kumar Sarma, Banaras Hindu University, India, Chetan Keswani, Banaras Hindu University, India.
No full textIncludes bibliographical references and index.This book includes 25 contributions from vastly experienced, global experts in PGPR research in a comprehensive and influential manner, with the most recent facts and extended case studies. Also, the chapters address the current global issues in biopesticide research.Mechanisms of Growth Promotion by Members of the Rhizosphere Fungal Genus Trichoderma / Artemio Mendoza-Mendoza, Guillermo Nogueira-L opez, Fabiola Padilla Arizmendi, Natalia Cripps-Guazzone, Mar ia Fernanda Nieto-Jacobo, Robert Lawry, Diwakar Kandula, Fatima Berenice Salazar-Badillo, Silvia Salas-Mu noz, Jorge Armando Mauricio-Castillo, Robert Hill, Alison Stewart and Johanna Steyaert -- Physiological and Molecular Mechanisms of Bacterial Phytostimulation / Randy Ortiz-Castro, Jes us Salvador L opez-Bucio and Jos e L opez-Bucio -- Real-time PCR as a Tool towards Understanding Microbial Community Dynamics in Rhizosphere / Gautam Anand, Upma Singh, Abhineet Sain, Virendra S. Bisaria and Shilpi Sharma -- Biosafety Evaluation: A Necessary Process Ensuring the Equitable Beneficial Effects of PGPR / Juan Ignacio V ilchez, Richard Daniel Lally and Rafael Jorge Le on Morcillo -- ^Role of Plant Growth-Promoting Microorganisms in Sustainable Agriculture and Environmental Remediation / Rama Kant Dubey, Vishal Tripathi, Sheikh Adil Edrisi, Mansi Bakshi, Pradeep Kumar Dubey, Ajeet Singh, Jay Prakash Verma, Akanksha Singh, B.K. Sarma, Amitava Rakshit, D.P. Singh, H.B. Singh and P.C. Abhilash -- Pseudomonas Communities in Soil Agroecosystems / Betina Cecilia Agaras, Luis Gabriel Wall and Claudio Valverde -- Management of Soilborne Plant Pathogens with Beneficial Root-Colonizing Pseudomonas / Dmitri V. Mavrodi, Mingming Yang, Olga V. Mavrodi and Shanshan Wen -- Rhizosphere, Mycorrhizosphere and Hyphosphere as Unique Niches for Soil-Inhabiting Bacteria and Micromycetes / Elena Voronina and Irina Sidorova -- ^The Rhizospheres of Arid and Semi-arid Ecosystems are a Source of Microorganisms with Growth-Promoting Potential / Fatima Berenice Salazar-Badillo, Silvia Salas-Mu noz, Jorge Armando Mauricio-Castillo, Jorge S aenz-Mata, Artemio Mendoza-Mendoza, Maria Fernanda Nieto-Jacobo and Johanna Steyaert -- Rhizosphere Colonization by Plant-Beneficial Pseudomonas spp.: Thriving in a Heterogeneous and Challenging Environment / Antoine Zboralski, Adrien Biessy and Martin Filion -- Endophytomicrobiont: A Multifaceted Beneficial Interaction / Shatrupa Ray, Vivek Singh, Kartikay Bisen, Chetan Keswani, Surendra Singh and H.B. Singh -- Contribution of Plant Growth-Promoting Bacteria to the Maize Yield / Vivian Jaskiw Szilagyi Zecchin, Angela Cristina Ikeda and Atila Francisco M ogor -- The Potential of Mycorrhiza Helper Bacteria as PGPR / Marieta Marin Bruzos -- Methods for Evaluating Plant Growth-Promoting Rhizobacteria Traits / Antonio Castellano-Hinojosa and E.J. Bedmar -- ^The Rhizosphere Microbial Community and Methods of its Analysis / Mukesh Meena, Manish Kumar Dubey, Prashant Swapnil, Andleeb Zehra, Shalini Singh, Punam Kumari and R.S. Upadhyay -- Improving Crop Performance under Heat Stress using Thermotolerant Agriculturally Important Microorganisms / M.K. Chitara, Chetan Keswani, Kartikay Bisen, Vivek Singh, S.P. Singh, B.K. Sarma and H.B. Singh -- Phytoremediation and the Key Role of PGPR / Elisabetta Franchi and Gianniantonio Petruzzelli -- Role of Plant Growth-Promoting Rhizobacteria (PGPR) in Degradation of Xenobiotic Compounds and Allelochemicals / Deepika Goyal, Janmejay Pandey and Om Prakash -- Harnessing Bio-priming for Integrated Resource Management under Changing Climate / Deepranjan Sarkar, Sumita Pal, H.B. Singh, Ranjeet Singh Yadav and Amitava Rakshit -- ^Unravelling the Dual Applications of Trichoderma spp. as Biopesticide and Biofertilizer / Vivek Singh, Shatrupa Ray, Kartikay Bisen, Chetan Keswani, R.S. Upadhyay, B.K. Sarma and H.B. Singh -- 21 Genome Insights into Plant Growth-Promoting Rhizobacteria, an Important Component of Rhizosphere Microbiome / Vasvi Chaudhry, Niladri Chaudhry and Shrikant S. Mantri -- Plant Growth-Promoting Rhizobacteria (PGPR): Mechanism, Role in Crop Improvement and Sustainable Agriculture / Pallavi Mittal, Madhu Kamle, Shubhangini Sharma, Pooja Choudhary, Devendra Pratap Rao and Pradeep Kumar -- PGPR: A Good Step to Control Several of Plant Pathogens / Laith K. Tawfeeq Al-Ani -- Role of Trichoderma Secondary Metabolites in Plant Growth Promotion and Biological Control / Jyoti Singh, Rahul Singh Rajput, Kartikay Bisen, Surendra Singh and H.B. Singh -- ^PGPR-Mediated Defence Responses in Plants under Biotic and Abiotic Stresses / Gagan Kumar, Jai Singh Patel, Anupam Maharshi, Arpan Mukherjee, Chetan Keswani, S.P. Singh, H.B. Singh and B.K. Sarma.1 online resourc
Abstract 5578: Small molecule modulators to understand the role of IDO1 and TDO2 in cancer
No full textAbstract
Introduction: Tumor immune escape mechanisms have been established as suitable targets for cancer therapy. Among these, tryptophan catabolism plays a central role in creating an immunosuppressive environment, leading to tolerance to potentially immunogenic tumor antigens. Tryptophan catabolism is initiated by either indoleamine 2,3-dioxygenase (IDO1/2) or tryptophan 2,3-dioxygenase 2 (TDO2), resulting in biostatic tryptophan starvation and l-kynurenine production. Recent literature has shown that IDO1 and TDO2 are expressed in multiple tumors, including solid tumors and play key roles in tumor progression other than immune escape. It has also been shown that IDO1 and TDO2 play distinct roles in driving the downstream effectors suggesting that their roles are perhaps non-redundant. Therefore, we developed series of novel small molecule modulators against IDO1 and TDO2 to understand their role in disease biology for multiple indications including cancer, depression and autoimmune disorders.
Methods: Rational design approaches were used to design novel IDO1 and TDO2 specific modulators; Potency of these inhibitors was assessed in the in vitro assays using purified IDO1 and TDO2 enzymes and in IDO1 and TDO2 over-expressing HEK293T cells by measuring the formation of kynurenine.
Results: In the in vitro biochemical assay using purified human TDO2, one of the NCEs from inhibitor series showed an IC50 of 0.09 μM against TDO2. Against purified human IDO1, this compound was inactive up to 30 μM, thereby showing >300-fold selectivity against IDO1. This TDO2 inhibitory activity translated well in TDO2-overexpressing HEK293 cells and, these NCEs inhibited kynurenine formation with an EC50 of ~2.5 μM. A second chemical series showed comparable dual inhibition of IDO1 and TDO2 activity. One of the molecules from this series showed IC50 of 0.2 and 0.08 μM in the biochemical assay and 1.7 and 0.8 μM in the cell based assay against IDO1 and TDO2, respectively. In addition, another series of NCEs showed strong activation of IDO1 and TDO2 activity. As compared to untreated control, formation of kynurenine was increased in a dose-dependent manner as observed by increase in fluorescence up to of 3-10 folds. One of the compounds from this series showed an EC50 of ~20- 30 μM in the biochemical assay as well as in 293T-based assay. Further mechanistic studies to understand the immune modulatory activity of these selective TDO2 modulators is underway. These tool compounds are being further optimized for potency and ADME properties to be developed as potential drug candidates.
Conclusion: To our knowledge such IDO1 and TDO2 specific small molecule activators have not been reported earlier. Therefore, these activators and inhibitors would serve as useful tool compounds in understanding the specific role(s) of IDO1 and TDO2 in disease biology and would also provide us the opportunity to target this pathway for various diseases, including cancer.
Citation Format: Shivani Rao Garapaty, Dhanalakshmi Sivanandhan, Guru Pavan Kumar Seerapu, Surendra Naidu, Shalini Chakelam, Pradeep Nagaraj, Reshma Das, Saravanan Vadivelu, Pravin Iyer, Chandrika Mulakala, Kannan Murugan, Somnath Mondal, Anjali Gautam, Saravanan Kandan, Manish Kumar Thakur, Sridharan Rajagopal, Sriram Rajagopal. Small molecule modulators to understand the role of IDO1 and TDO2 in cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5578. doi:10.1158/1538-7445.AM2017-5578</jats:p
A Study of Spider Diversity and Habitat Distribution in Rajnandgaon Block, Chhattisgarh, India
Get PDFThis study investigates the diversity and habitat of spiders in Rajnandgaon Block, Chhattisgarh, India, as well as their ecological roles. The research utilized random sampling and spiders were obtained through hand collection, sweep nets, pitfall traps, litter sifting, and beating techniques. Specimens were fixed in ethanol and identified morphologically based on taxonomic keys. Biodiversity was examined using Shannon-Wiener, Simpson\u27s Index, and evenness of species. A total of 25 spider species from 20 genera, 9 families, and the order Araneae were recorded across urban, forest, and agricultural habitats. Salticidae (jumping spiders) constituted a major part of the recorded species. Some common species include Marpissa obtusa, Menemerus bivittatus, and Plexippus paykulli. The study recorded that tropical forest ecosystems harbored tarantulas (Grammostola pulchra and Grammostola rosea), whereas lynx spiders (Peucetia viridans and Oxyopes salticus) thrived in forest and shrubland. Habitat diversity played a significant role in supporting spider species as they prefer microhabitats such as tree trunks, rocks, and shaded areas. The contribution of spiders toward ecological services also focuses on pest control. The findings suggest that seasonal variations impact species distribution, which aligns with earlier studies on spider diversity in India. This study highlights the necessity of conservation to preserve spider habitats and maintain their ecological functions. Further research should include seasonal patterns, microhabitat preferences, and pest control functions of spiders
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No full textABSTRACT: An accurate, precise and reproducible UV-spectrophotometric methods and liquid chromatographic assay method were developed and validated for the determination of Levofloxacin and Ornidazole in tablet dosage form. Spectrophotometric estimation was done by simultaneous equation method and 50 % methanol as solvent. In this method λmax for LEVO and OZ were selected at 293.5nm and 318nm. RP-HPLC analysis was carried out using Prontosil C-18 column (4.6 x 250mm, 5μ particle size) and mobile phase composed of Acetonitrile: 0.05 % Ortho-phosphoric acid in water pH 3.0 (45:55 % v/v)at a flow rate of 1.0 ml/min and chromatogram was recorded at 303 nm. Linearity was evaluated over the concentration range of 4-20 μg/ml and 8-40 μg/mL for LEVO and OZ in both UV spectrophotometric and RP-HPLC method (the value of r 2 Keywords
ALLELOPATHIC INVESTIGATION OF CHENOPODIUM MURALE (L.) ON ZEA MAYS (L.) AND HORDEUM VULGARE (L.)
No full textThe aspects of allelopathy, allelochemicals, mechanism of allelopathy of weed plants and their impact on crops are discussed in this review paper. An overview of the mode of action of the weed and different strategies and their direct and indirect impact on the overall agricultural system were analyzed. After the passing of the 20th century, the curiosity of the researchers took a remarkable work in comparison to the last decades of the 19th century that was needed too mainly because there was little awareness to the farmers of farming. They are using old practices and synthetic agrochemicals still now, thus having a long-lasting negative impact on the overall factors that have the ability to keep ecosystem balance. There are advanced agriculture techniques and tools that are exploring day by day with the reference to sustainable problems. Allelochemicals are present in all types of tissues and are released by a variety of mechanisms, including decomposition of residues, volatilization and root exudation into the rhizosphere. Allelochemical its structure and mode of action are different and may offer a potential for the future development of herbicide. In this context, there is the discussion of the invasiveness of Chenopodium murale (L.) on certain selected crop species and the aggressiveness of different plant species on the same
Modeling of a neural network based controller for vibration suppression of a building structure
No full text<b>PRODUCTOMETRIC STUDY OF SCIENTISTS OF ICAR'S NATIONAL RESEARCH</b> <b>CENTRE FOR SOYBEAN (NRCS)</b>
No full text11-21
Information personnel conduct studies on citation and
bibliometric analysis for knowing the extent of utility of
joumals, conference proceedings and other literature.
In this study, productometric analysis of contributions of
National Research Centre for Soybean, Indore,
has been
carried out for the period 1987 - 2001
in terms of number
of research articles produced by its scientists. The study
is based on a chronological documentation list prepared
for the purpose along with author and subject indexes.
Also analyses average number of papers per year, types
of documents publishing the papers along with names of
the journals, subject and language distribution.
Authorship pattern is also studied in this paper. It also
gives method of calculating score of individual authors,
calculates their scores and rank orders. Concludes with
strengths and weaknesses of soybean research in India.
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Synthesis and evaluation of biological activity of some novel carbazole derivatives
No full text60-64Natural and synthetic carbazoles contains potent activity against inflammation. Some novel carbazole derivatives have
been synthesized and also checked for activity against inflammation by using Carrageenan Induced Inflammation in Rat
Paw Edema Model. Structures of synthesized carbazole derivatives have been confirmed on the basis of FT-IR, 1H NMR
and elemental analysis. During the evaluation of biological activity, newly synthesized compounds (4a) and (4f) are found
more potent against inflammation
Ossifying fibroma of nasal cavity: A rare case report
Get PDFOssifying fibroma (OF) is considered a rare benign fibro-osseous lesion that occurs most commonly in female patients. It mainly involves the mandibular and maxillary bones, although in rare cases, it may develop within the nasal cavity. Here, we present a rare case report of OF of the nasal cavity in a 30-year-old female. OF is usually diagnosed by histopathological examination and treated by enucleation. However, larger lesions require radical resection
ENHANCEMENT OF OPTICAL PROPERTIES OF BAGASSE PULP BY IN-SITU FILLER PRECIPITATION
No full textIn-situ precipitation of calcium carbonate in bagasse fibers resulted in a very significant increase in specific scattering coefficient and consequently large improvements in opacity and brightness of the handsheets made from such pulp. At the same level of filler loading, the scattering coefficient of in-situ precipitated pulp was much greater than for directly loaded pulp. In-situ precipitation of calcium carbonate caused a drop in strength properties of bagasse pulp, but such loss could be recovered to a large extent by blending with other pulps. The effect of in-situ precipitation of calcium carbonate on pulp fibers was quite different for bagasse pulp from hardwood pulp. In-situ precipitation of calcium carbonate on hardwood fibers showed neither much improvement in optical properties nor much reduction in strength properties
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