1,721,150 research outputs found
Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors
No full textBackground: D-chiro-inositol (DCI) and glucose transporter inhibitors may inhibit myo-inositol (MI) transporters, and the aim is to clinically evaluate their effect on MI absorption. Research design and methods: Fasting 18 healthy volunteers received orally 6000 mg MI, 6000 mg MI with 1000 mg DCI, and 6000 mg MI with SelectSIEVE® Apple PCQ and Sorbitol, Maltodextrin and Sucralose (PCQ- SMS), in three different phases with a washout period of 7 days. At each phase, blood samples were collected before administration, and every 60 minutes until 540 minutes after administration. MI plasma levels (μmol/L) were quantified by gas chromatography-mass spectrometry; maximum plasma concentration (Cmax), time to reach it (Tmax), and the area under the time-concentration curve of MI (AUC 0-540) were evaluated. Results: The Cmax of MI alone (Tmax=180min) was 1.29-fold higher than those of MI with DCI (Tmax=180min) (p<0.001) and 1.69-fold higher than those of MI with PCQ-SMS (Tmax=240min) (p<0.001). The AUC 0-540 was reduced by 19.09% in MI plus DCI (p=0.0118) and of 31.8% in MI plus PCQ-SMS (p<0.001) as compared to MI alone. Conclusions: DCI, glucose transporter inhibitors and sugars, such as sorbitol and maltodextrin, seem to inhibit MI absorption, decreasing MI plasma concentration as compared to MI alone
Risk, safety, and outcome monitoring in the IVF clinic
No full textRisk, safety, and outcome monitoring in the IVF clini
Reply to Research on intrauterine manipulators for endometrial cancer: attention to study-level characteristics
No full textRepl
The Significant Risk Factors of Intra-Operative Hemorrhage during Laparoscopic Myomectomy: A Systematic Review
No full textLaparoscopic myomectomy (LM) is becoming increasingly common in the management of uterine myomas and is usually offered regardless of the number, location, and size of the myomas. It has a generally low rate of periprocedural complications and is preferred to laparotomy for several reasons that are not limited to decreased length of hospital stay, number of sutures, smaller incisions, and decreased pain. However, blood loss during LM remains a challenge. To be able to stratify patients and provide better management after LM, it is crucial to identify these predictors of blood loss. Therefore, the aim of this review was to identify the risk factors for periprocedural blood loss after laparoscopic uterine myomectomy. According to our data synthesis, age, body mass index, and phase of the menstrual cycle do not seem to affect the blood loss during LM. Conversely, size and number of myomas, as well as operative time, was directly related to the increase of blood loss
Intraoperative findings of duplicated Inferior Vena Cava during laparoscopic para-aortic lymphadenectomy
No full textA 57-year-old patient with a diagnosis of ovarian clear cell carcinoma after bilateral adnexectomy underwent surgical staging at our gynecologic oncologic center. During laparoscopic para-aortic lymphadenectomy, we identified and exposed the double infrarenal vena cava (Edwards’ Classification [ 1 ]), with the left inferior vena cava terminating in the left renal vein (Figure 1). No paracaval or interaortocaval lymph nodes were found on the left side. Surgery was performed without intraoperative or postoperative complications
Primary hepatic pregnancy: report of a case treated with laparoscopic approach and review of the literature
No full textObjective: To report a case of primary hepatic pregnancy complicated by acute hemoperitoneum that was treated with a laparoscopic approach. Design: Case report and review of the literature. Setting: Obstetrics and gynecology unit of a university hospital. Patient(s): A 37-year-old pregnant woman who presented with vaginal bleeding. Intervention(s): Diagnosis by abdominal ultrasound and computed tomography. Main Outcome Measure(s): Patient recovery after minimally invasive laparoscopic surgery and monitoring. Result(s): A hepatic ectopic pregnancy complicated by hemoperitoneum was diagnosed. The hepatic pregnancy was surgically removed via laparoscopy through a retroperitoneal approach, and the patient's human chorionic gonadotropin level was subsequently monitored. The patient's postoperative course was uneventful, and the serum human chorionic gonadotropin level dropped to zero. Conclusion(s): Only 39 cases of hepatic pregnancy have been reported in the literature, making it an exceptional category among abdominal pregnancies. Hepatic localization should be ruled out in cases of unknown pregnancy location. Abdominal ultrasound has a key role detecting hepatic localization and excluding other abdominal implantation sites. Laparoscopic surgery represents a feasible approach for the treatment of first trimester hepatic pregnancies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Association of a large vulvar tumor in a young premenopausal woman with recurrent pseudoangiomatous stromal hyperplasia of the breasts
Full text linkPseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the breast tissue that typically affects women in the reproductive age. Pseudoangiomatous stromal hyperplasia usually presents as a localized, painless, firm mass or as a diffuse thickened area of the breast. Rarely, it can arise along the embryonic milk line, up to the anogenital region, where it simulates angiosarcomas. Awareness of this uncommon condition is important in order to avoid unnecessary aggressive excisional surgical procedures. For this purpose, we present a case of nodular pseudoangiomatous stromal hyperplasia arising in the vulva in a patient with recurrent pseudoangiomatous stromal hyperplasia of the breast
Molecular Biology of Human Fertility: Stepping towards a Tailored Approach
No full textClinical pregnancies and live births result from a complex interaction of molecular pathways at the level of the female and male gametes during their development and interaction for fecundation, and the subsequent development of the embryo before, during, and after implantation [...
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