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Effective Labeling of Molecular Surface Points to Matching Cavitiesand Locate Putative Binding Sites
No full textDiscovery of Similar Regions on Protein Surfaces
No full textDiscovery of a similar region on two protein surfaces can lead to important inference about the functional role or molecular interaction of this region for one of the proteins if such information is available for the other. We propose a new characterization of protein surfaces based on a spin image representation of the surfaces that facilitates the simultaneous search of the entire surface of each of two proteins for a matching region. For a surface point, we introduce spin image profiles which are related to the degree of exposure of the point to identify structurally equivalent surface regions in two proteins. Unlike some related methods, we do not assume that a known fixed region of one of the proteins surfaces is to be matched on the other protein surface. Rather, we search for the largest similar regions on each of the two surfaces. In spite of the fact that this approach is entirely geometric and no use is made of physicochemical properties of the protein surfaces or fold information, it is effective in identifying similar regions on both surfaces even when the region corresponds to a binding site on one of the proteins. The discovery of similar regions on two or more proteins also has implications for drug design and pharmacophore identification. We present experimental results from datasets of more than 50 protein surfaces
A case of occipital epilepsy in an elderly woman
No full textA 73-year-old woman experienced stereotype episodes of complex visual hallucinations over five months. Initially, they were rare and consisted of pleasant static pictures emerging from the left visual field, usually lasting 5 to 10 seconds. Subsequently, they became moving, tormenting pictures, recurring several times a day. On admission, neurological examination revealed reduced contact, nystagmus with fast phase to the left and a left homonymous hemianopia. Electroencephalography (EEG) demonstrated recurrent epileptic discharges starting from the right occipital lobe. The EEG showed sporadic occipital epileptiform activity during the attack-free periods. Phenytoin therapy stopped the seizures and normalized the EEG. An ischemic lesion in the right occipital lobe was detected on cerebral magnetic resonance imaging (MRI) with gadolinium. She continued antiepileptic treatment without recurrence of seizures in the following nine months. This observation of vascular damage-related occipital seizures indicates that epilepsy may be the cause of misdiagnosed behavioral and cognitive disturbances in the elderly. Its prompt recognition is important, since treatment may resolve this type of disorder
Effects of indomethacin and polyunsaturated phosphatidylcholine on short-term control of renal water excretion.
No full textRelation between acute changes in diuresis and renal prostaglandins. II. Induced antidiuresis].
No full text[Effects of acute changes in water balance on hydrosaluresis and on urinary excretion of prostaglandin E, in the presence and absence of a cyclooxygenase inhibitor]
No full text
Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria].
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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