1,720,964 research outputs found
“Retinoids and malignant Melanoma: a pathways of proliferation inhibition on SK MEL28 cell line”
No full textRetinoids and Malignant Melanoma: a pathway of proliferation inhibition on SK MEL 28 cell line
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Histone deacetylase Inhibitors enhance retinoid response in human breast cancer cell lines
No full textSolid tumors develop resistance to retinoids during
carcinogenesis. One of the strategies to overcome this
resistance may include the combination of these molecules
with other differentiating, cytotoxic or chromatin-remodelling
agents. We analysed the anti-proliferative activity of two
histone-deacetylase inhibitors (HDACIs), Trichostatin A
(TSA) and Sodium Phenylbutyrate (PB), alone or combined
with retinoids, all-trans retinoic acid (ATRA) and Ro 41-5253,
on two human breast cancer cell lines: the hormone-dependent
MCF-7 and the hormone-independent MDA-MB-231. These
lines responded differently to retinoids: MCF-7 were sensitive,
whilst MDA-MB-231 were rather resistant. When the retinoids
were combined with HDACIs, these molecules potentiated the
retinoid activity on growth inhibition, especially for the
association Ro 41-5253 and TSA. By FACS analysis we
observed that the anti-proliferative effects were only partially
due to pro-apopotic mechanisms, suggesting a cell-cycle block.
The efficacy of the retinoids/HDACIs combinations could
represent a new strategy in breast cancer chemotherapy,
allowing inhibition of both ER+ and ER- cell populations
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Prognostic value of cell cycle regulatory proteins in muscle-infiltrating bladder cancer
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
4-OH Tamoxifen does not interfere with Bicalutamide inhibitory effects on human prostatic cancer cells in vitro.
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