1,720,983 research outputs found
Platelet function in diabetes mellitus : studies on postprandial platelet activation and aspirin treatment
No full textDiabetes mellitus (DM) is a prothrombotic disease which is associated with a high risk for cardiovascular events, especially in type 2 DM (T2DM). The aim of this work is to contribute to the improvement of cardiovascular risk in DM. Patients with DM have reduced responses to antiplatelet treatment with aspirin, perhaps due to an increased platelet turnover, and this is associated with a poor outcome. Postprandial hyperglycemia is an independent risk factor for cardiovascular complications.We compared the laboratory responses to twice daily dosing of aspirin 75 mg, the regular once daily dose of 75 mg or a higher once daily dose of 320 mg in an open cross-over study in 25 patients with T2DM and micro/macrovascular complications, We found an improved response to 75 mg twice daily as compared to both once daily doses using two whole blood methods; impedance platelet aggregometry and the IMPACT-R cone and platelet analyzer. Both patients with a high and low platelet turnover could benefit from twice daily dose of aspirin.The role of postprandial hyperglycemia in postprandial platelet activation was examined in a randomized cross-over study comparing premeal insulin (0.1 and 0.2 U/kg insulin aspart) and placebo in 18 patients with T2DM. Platelet activation was studied in the fasting state, before and after normalizing glucose levels, and 90 min after a carbohydrate rich meal. Although postprandial glucose levels decreased after insulin injection, platelet activation increased. Glucose normalization with IV insulin aspart before the meal also resulted in platelet activation mainly via the thromboxane pathway as studied with the thromboxane analogue U46619 using flow cytometry. The postprandial platelet activation was correlated directly to insulin levels and inversely to glucose levels. We therefore concluded that postprandial platelet activation in T2DM is related to insulin rather than to glucose levels.The role of insulin in postprandial platelet activation was further investigated by comparing T1DM (n=11) and T2DM (n=9), without premeal insulin before and after a carbohydrate rich meal. T1DM patients, who had very high postprandial glucose levels due to inability to secrete insulin, had no platelet activation after the meal. These findings further support the role of insulin in postprandial platelet activation.Microparticles derived from platelets, monocytes and endothelial cells were formed after a carbohydrate meal in both patients with T1DM and T2DM in the above study. The microparticles had a prothrombotic potential (thrombin generation assay) which was related to phosphatidylserine and not to tissue factor expression. As opposed to the importance of insulin in postprandial platelet activation seen in T2DM, the procoagulant microparticles increased similarly or even more in T1DM. Therefore microparticle release may be related to hyperglycemia rather than hyperinsulinemia.This work suggests that twice daily dosing can improve the response to low-dose aspirin treatment in T2DM which might improve cardiovascular prognosis, and that liberal usage of premeal insulin may not benefit patients with T2DM as it contributes to postprandial platelet activation, and insulin treatment has been related to increased cardiovascular risk in DM. Postprandial platelet activation does not occur without premeal insulin in T1DM but should also be studied after insulin. Prothrombotic microparticle release however occurs in both T1DM and T2DM after the meal.List of scientific papersI. Spectre G, Arnetz L, Östenson CG, Brismar K, Li N, Hjemdahl P. Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. Thromb Haemost. 2011 Sep;106(3):491-9. https://doi.org/10.1160/TH11-04-0216 II. Spectre G, Östenson CG, Li N, Hjemdahl P. Postprandial platelet activation is related to postprandial plasma insulin rather than glucose in patients with type 2 diabetes. Diabetes. 2012 Sep;61(9):2380-4. https://doi.org/10.2337/db11-1806 III. Spectre G, Stålesen R, Östenson CG, Hjemdahl P. Meal-induced platelet activation differs between patients with type 1 and type 2 diabetes. [Submitted].IV. Spectre G, Mobarrez F, Stålesen R, Varon D, Wallén H, Östenson CG, Hjemdahl P. Meal intake increases procoagulant microparticle formation in diabetes. [Manuscript].</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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