1,721,014 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
THE METABOLISM-DEPENDENT MAINTENANCE OF CELL VOLU-ME AND ULTRASTRUCTURE IN SLICES OF MORRIS HEPATOMA 3924 A.
No full textTransport of pyruvate in mitochondria from different tumor cells.
No full textA comparative study of the transport of pyruvate in mitochondria isolated from normal rat liver and from three tumors has been carried out. The Km for net pyruvate uptake in mitochondria isolated from Ehrlich ascites tumor cells is practically equal to that measured in normal rat liver mitochondria while, on the other hand, it is higher in Morris hepatomas 44 and 3924A. The Vmax of pyruvate uptake is depressed in all three types of tumor mitochondria as compared to that in the rat liver mitochondria, with the depression being higher in Morris hepatoma 3924A mitochondria. The lower activity of pyruvate translocator in mitochondria isolated from tumor cells as compared to that in rat liver mitochondria is also shown by depression of the rate of pyruvate-supported oxygen uptake. The results document a decreased activity of the pyruvate translocator in tumor mitochondria which seems to be correlated with the growth rate of the tumor cells
Maternal Technology Distraction and Its Associations With Stress and Parenting During the COVID-19 Pandemic
No full textThe widespread adoption of digital technology devices has introduced unique challenges to modern parenthood, especially during the COVID-19 pandemic when parents relied on digital technology more than ever before. Parents have experienced significant challenges during the COVID-19 pandemic, with mothers being especially vulnerable to stress and mental health problems. This study investigates associations between technology distraction of mothers while spending time with their offspring, psychological well-being (stress sensitivity), and parenting behaviors (warmth and indifference) during the COVID-19 pandemic. Mothers (n = 246) of adolescents (aged 13-18) who attended public secondary schools in Italy completed an online survey during the fourth wave of COVID-19. The pattern of associations was analyzed via path analysis. COVID-19 pandemic-induced stressors were positively associated with perceived stress, which was positively associated with technology distraction of mothers when spending time with their offspring. Furthermore, maternal technology distraction was positively associated with indifference and negatively associated with warmth. Perceived stress was negatively associated only with warmth. Strategies to mitigate stress during times of crisis and adversity might be useful for potentially vulnerable targets (e.g., mothers living with offspring during the COVID-19 pandemic). Information and prevention actions should be focused on how parents use digital devices while with their offspring
Proton-cation translocation in tumor cell mitochondria.
No full textThe capacity of mitochondria isolated from tumor cells to conserve the transmembrane electrochemical proton gradient set up by respiration has been studied. In a K+ medium, mitochondria from Ehrlich ascites tumor cells exhibit a capacity to conserve aerobic delta microH comparable to that displayed by normal rat liver mitochondria. Mitochondria from Morris hepatoma 3924A show a decreased capacity to store delta microH+, which is principally due to lowering of delta pH. In a Na+ medium, both species of tumor mitochondria show a significant decrease of aerobic delta pH, while delta psi is the same, with respect to rat liver mitochondria. Experiments on passive swelling show that mitochondria from ascites tumor cells have an enhanced permeability to chloride salts of monovalent cations and increased activity of the Na+ (K+)-H+ exchange system of the mitochondrial membrane with respect to normal mitochondria. The enhanced activity of this system in ascites cells is also shown by the characteristics of respiration-linked proton translocation in submitochondrial particles and subsequent anaerobic proton diffusion. It is concluded that the decreased capacity of mitochondria from tumor cells to conserve aerobic delta pH is due to enhanced cyclic flow of Na+ across the membrane
Monoclonal antibody 35.8 recognizes human, mouse and rat MnSOD in western blot and immunostaining.
No full textOBSERVATIONS ON THE REGULATION OF CELL VOLUME AND METABOLIC CONTROL IN VITRO. CHANGES IN THE COMPOSI-TION AND ULTRASTRUCTURE OF LIVER SLICES UNDER CONDI-TIONS OF VARYING METABOLIC AND TRANSPORTING ACTIVITY.
No full textINTERACTION OF Na+ AND K+ TRANSPORT WITH AEROBIC ENERGY METABOLISM IN SLICES OF MORRIS HEPATOMA 3924 A.
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