25 research outputs found
Correction to: Efficacy of Collagenase Clostridium histolyticum (Xiapex®) in Patients with the Acute Phase of Peyronie’s Disease (Clinical Drug Investigation, (2020), 40, 6, (583-588), 10.1007/s40261-020-00916-4)
No full textThe original version of this article unfortunately contained a mistake. The fifth author’s given name is Francesco and the family name is Lotti. Title page: Authors’ names, which previously read: Andrea Cocci, Fabrizio Di Maida, Giorgio Ivan Russo, Paolo Capogrosso, Lotti Francesco, Michele Rizzo, Marina Di Mauro, Andrea Salonia, Gianmartin Cito, Marco Falcone, Andrea Romano, Gaia Polloni, Juan Ignacio Martinez-Salamanca, Esaù Fernández-Pascual, Andrea Minervini & Nicola Mondaini Should read: Andrea Cocci, Fabrizio Di Maida, Giorgio Ivan Russo, Paolo Capogrosso, Francesco Lotti, Michele Rizzo, Marina Di Mauro, Andrea Salonia, Gianmartin Cito, Marco Falcone, Andrea Romano, Gaia Polloni, Juan Ignacio Martinez- Salamanca, Esaù Fernández-Pascual, Andrea Minervini & Nicola Mondain
Penile length and circumference dimensions: A large study in young Italian men
No full textThe aim of the present study was to evaluate the size of the penis in flaccidity and in erection of Italian men. A total of 4,685 men living in Italy and who have been visited at the Italian urology operating units were involved in the study between January 2019 and January 2020. Each patient was given details on how to measure their penis (erect length and circumference) in flaccidity and in erection, from the lower base to the distal penile tip. Mean (standard deviation [SD]) flaccid penis length was 9.47 (2.69), mean (SD) flaccid penis circumference was 9.59 (3.08), mean (SD) erect penis length was 16.78 (2.55) and mean (SD) erect penis circumference was 12.03 (3.82). At the linear regression analysis, height was associated with flaccid penis length (β = 0.04; p-value = .01), and erect penis length was (β = 0.05; p-value
< .01) and erect penis circumference was (β = 0.06; p-value < .01). Height is proportional to the length of the penis in flaccidity and in erection, and to the circumference in erection. The increase in BMI leads to a reduction in the length of the erect penis, as well as weight gain reduces the length of the flaccid penis
La Naturaleza sufre: el Buen Vivir como salida educativa
No full textEstamos más cerca del colapso mundial de lo esperado; si el extractivismo descarnado, el consumismo sin control y el individualismo extremo de las sociedades capitalistas no se detiene, “herida de muerte”, Gaia, no podría recuperarse. No hay consenso aún en cómo salir de dicha crisis. Una de las salidas propuestas es el Buen Vivir, esta cosmovisión ancestral, como una filosofía política impulsada por movimientos indígenas andinos, ha sido incluida en las Constituciones boliviana y ecuatoriana. En el contexto chileno, desde el pueblo Mapuche también se comparte el concepto de Buen Vivir, Kyme Mogen; aún sin permear las capas de movimientos políticos, esta comprensión se hace presente en la lucha educativa territorial. Desde una aproximación del análisis crítico del discurso, se confronta el texto de lo que puede ser una de las primeras currícula comunitaria que se levanta y aprueba impulsada por comunidades organizadas en Chile. Desde lo analizado, se desprende la simbiótica relación que se tiene con la naturaleza, y la forma complementaria que presenta esta comprensión del mundo, tanto el visible físico como el invisible espiritual. La salida educativa aquí presentada se vuelve otra de las luchas necesarias para poder superar la presente crisis ambiental
War powers: reforming the law, with case studies of US Military participation in the Persian Gulf and Haiti
No full textThe thesis studies the U.S. legal framework on war powers, concluding that it has not allowed the President and Congress to work together on war powers issues. From the constitutional viewpoint, this lack of friendly environment arises from the fact that the Constitution shares war powers between the presidency and the Congress, producing the conflict. From a political viewpoint, this dispute is explained by the presidential willingness to use the war powers without congressional authorization. In addition, every time lawmakers have sued the president for violations of the War Powers Resolution, the judiciary has ruled that this is a political question. Legally speaking, this conflict could end in a constitutional conflict. Politically speaking, this dispute could also have an important impact on the role that the United States plays within the community of nations and on the U.S. national security goal of promoting democracy abroad. In order to offer a possible solution, the thesis proposes legal changes that would strengthen the consultation process established by both the War Powers Resolution and the National Security Act of 1947.Approved for public release; distribution is unlimited.Chilean Army author (retired).http://archive.org/details/warpowersreformi10945937
Predictive Factors of Patients’ and Their Partners’ Sexual Function Improvement After Collagenase Clostridium Histolyticum Injection for Peyronie's Disease: Results From a Multi-Center Single-Arm Study
No full textBackground: Collagenase Clostridium histolyticum (CCH; Xiapex) injections represent the only licensed medical treatment for Peyronie's disease (PD). Aim: To evaluate the efficacy and safety of CCH injections in men with stable PD, using a modified treatment protocol and to assess partners’ bother improvement in a large cohort of White-European sexually active heterosexual men treated in a single tertiary-referral center. Methods: All the 135 patients enrolled underwent a thorough assessment, which included history taking, physical examination, and pharmacologically induced artificial erection test (intra-cavernous injection) to assess the degree of penile curvature (PC) at baseline and after the completion of the treatment. Patients with calcified plaque and/or ventral curvature were excluded. All patients underwent a modified treatment protocol, which consisted of 3 intra-lesional injections of 0.9 mg of CCH performed at 4-week intervals at the point of maximum curvature. After each injection, patients were instructed to follow a strict routine involving daily penile stretching in the intervals between injections. Outcomes: International Index of Erectile Function (IIEF)–15, Global Assessment of PD, PD questionnaires (PDQ), and Female Sexual Function Index (FSFI) questionnaire were performed at baseline and at the end of treatment. Results: Overall, 135 patients completed the study protocol. Before treatment, 18 (13.33%) partners showed a degree of sexual dysfunction. Baseline median IIEF–15, FSFI, and PDQ scores were, respectively, 59.0, 35.0, and 23.0. Overall, both IIEF–total and all domains significantly improved after treatment (all P <.01). A PC mean change of 19.07 (P =.00) was measured. At the univariate linear regression analysis, IIEF–15, IIEF–erectile function, IIEF–sexual desire, and IIEF–intercourse satisfaction were positively associated with FSFI (all P ≤.03); conversely, PDQ–penile pain, PDQ–symptom bother, and post-treament penile curvature (P ≤.04) were associated with a decreased FSFI score. Furthermore, median change of PC was significantly associated with median change of FSFI (r = 0.25; 95% CI 0.02–0.11; P =.004). Global satisfaction after treatment was 89.6% (121/135). Clinical Translation: This modified CCH treatment protocol could improve both patients’ and partner's sexual function. Strength and limitations: This was an open-label, single-arm clinical study, without placebo. where only heterosexual couples in stable relationships were included. Furthermore, no real assessment of female sexual distress was carried out and long-term sexual function in both patients and female partners were not taken into account. Conclusions: The modified treatment schedule with CCH injections for stable PD has a positive impact on both patients’ and partners’ sexual function in heterosexual couples with a stable sexual relationship. Cocci A, Russo GI, Salonia A, et al. Predictive Factors of Patients’ and Their Partners’ Sexual Function Improvement After Collagenase Clostridium Histolyticum Injection for Peyronie's Disease: Results From a Multi-Center Single-Arm Study. J Sex Med 2018;15:716–721
Efficacy of Collagenase Clostridium histolyticum (Xiapex®) in Patients with the Acute Phase of Peyronie’s Disease
No full textBackground and Objective: Plaque formation ordinarily takes place in the acute phase of Peyronie’s disease. There is no unanimous consent regarding the management of the acute phase of Peyronie’s disease. The objective of this study was to evaluate the advantages of using a single intralesional injection of collagenase Clostridium histolyticum in patients with the active phase of Peyronie’s disease and to assess its effect on disease progression by reducing penile curvature and ameliorating pain during sexual intercourse. Methods: Sexually active men aged older than 18 years with the acute phase of Peyronie’s disease were enrolled. All patients received treatment with a single intralesional injection of collagenase Clostridium histolyticum. The primary outcome of the study was the change in penile curvature after treatment while secondary outcomes were the change in sexual function (International Index of Erectile Function [IIEF-5]) and in the Peyronie Disease Questionnaire (PDQ) and its sub-scores, PDQ-PS (psychological symptoms), PDQ-PP (penile pain) and PDQ-BD (bother disease). Results: Overall, 74 patients were enrolled. Mean penile curvature at baseline was 41.1° ± 12.2°. The mean changes before and at the 3-month evaluation in terms of penile curvature, Visual Analog Scale score at rest, and Visual Analog Scale score during intercourse were − 19.3 ± 8.4 (p < 0.0001), − 0.8 ± 1.1 (p < 0.0001) and − 3.8 ± 0.9 (p < 0.0001) with the benefit persisting also after 6 months. Moreover, improvements of mean IIEF-5 score (1.1 ± 0.9, p = 0.03; 0.9 ± 0.5, p = 0.02), PDQ-PS (− 2.7 ± 2.2; − 2.5 ± 2.0, p = 0.01), PDQ-PP (− 1.2 ± 1.6; − 1.1 ± 1.2, p = 0.02) and PDQ-BD (− 3.8 ± 3.4; − 3.5 ± 3.1, p = 0.001) were observed 3 and 6 months after the end of treatment, respectively. At the multivariable regression analysis, the time since disease onset (modelled with non-linear terms) and baseline curvature were independently associated with the degree of curvature improvement (coefficient: 0.30; 95% confidence interval 0.16–0.44) after a single intralesional injection (all p < 0.03). Conclusions: Although intralesional therapy with collagenase Clostridium histolyticum is not yet indicated for the acute phase of Peyronie’s disease, these preliminary results suggest the effectiveness of this minimally invasive option by improving penile curvature and IIEF-5 and PDQ scores
Documenti e studi sulla tradizione filosofica medievale, 28, 2017
No full textThe present volume hosts the proceedings of the conference “A Crossroad between East and West: The Latin Medieval Translations of the Kitāb al-Šifāʾ (Book of the Cure) of Ibn Sīnā (Avicenna)”, which took place in Pisa, Scuola Normale Superiore, on 1-3 July 2015 in the framework of the project “Philosophy on the Border of Civilizations and Intellectual Endeavours: Towards a Critical Edition of the Metaphysics (Ilāhiyyāt of Kitāb al-Šifāʾ) of Avicenna (Ibn Sīnā)”, financed by the European Research Council (ERC Advanced Grant, 2014-2019, www.avicennaproject.eu). Some additional articles (N. Caminada, A. Astesiano, N. Polloni, I. Panzeca) complement the papers first presented at the conference. The decision to devote a conference expressly to the Latin translations of the various parts of Avicenna’s philosophical masterpiece produced during the Middle Ages, and, now, to publish the papers of the meeting in a self-standing volume that deals comprehensively with the topic – in both cases for the first time, to the best of our knowledge – finds its justification in the necessity of approaching this key event of the Arabic-into-Latin transmission of philosophical culture in a comprehensive rather than piecemeal way.Table of contents
DOCUMENTI E STUDI SULLA TRADIZIONE FILOSOFICA MEDIEVALE XXVIII, 2017:
AMOS BERTOLACCI, TOMMASO ALPINA, Introduction — FRANÇOISE HUDRY, La traduction latine de la Logica Avicennae et son auteur — SILVIA DI VINCENZO, Is There a versio vulgata of Avicenna's Kitāb al-Šifāʾ ? On the Hypothesis of a Double Recension of Kitāb al-Madḫal — NICCOLÒ CAMINADA, A Latin Translation ? The Reception of Avicenna in Albert the Great's De praedicamentis — RICCARDO STROBINO, Avicenna's Kitāb al-Burhān, II.7 and its Latin Translation by Gundissalinus : Content and Text — GAIA CELLI, The Rhetoric Section of the Kitāb al-Šifāʾ : Hermannus Alemannus' Latin Translation and the Arabic Witnesses — FRÉDÉRIQUE WOERTHER, Citer/traduire. La traduction arabo-latine de la Rhétorique d'Aristote par Hermann l'Allemand et les citations d'al-Fārābī et Averroès — JULES JANSSENS, The Liber primus naturalium, i.e., the Physics of the Avicenna latinus — ALESSIA ASTESIANO, L'inizio di un movimento nella fisica del continuo : Avicenna lettore di Aristotele (Libro della guarigione, Fisica, III, 6) — CRISTINA CERAMI, The De Caelo et Mundo of Avicenna's Kitāb al-Šifāʾ : An Overview of its Structure, its Goal and its Polemical Background — SILVIA DI DONATO, Les trois traductions latines de la Météorologie d'Avicenne : notes pour l'histoire du texte — ELISA RUBINO, The Commentary of Alfred of Shareshill on the pseudo-Aristotelian De mineralibus — TOMMASO ALPINA, Al‐Ǧūzǧānī Insertion of On Cardiac Remedies in Avicenna's Book of the Soul : the Latin Translation as a Clue to his Editorial Activity on the Book of the Cure ? — AAFKE VAN OPPENRAAY, Avicenna's Liber de animalibus ('Abbreviatio Avicennae'). Preliminaries and State of Affairs — RÜDIGER ARNZEN, Double Translations in the Latin Version of the Metaphysics of Avicenna's Kitāb al-Šifāʾ — ALFONSO QUARTUCCI, Avicenna's Notion of al-mawḍūʿ al-awwal ('first subject') in Ilāhiyyāt, I, 1-2 and its Latin Reception — AMOS BERTOLACCI, The Latin Translation and the Original Version of the Ilāhiyyāt (Science of Divine Things) of Avicenna's Kitāb al-Šifāʾ — NICOLA POLLONI, Gundissalinus and Avicenna : Some Remarks on an Intricate Philosophical Connection — IVANA PANZECA, On the Persian Translations of Avicenna's Ilāhiyyāt — INDICE DEI MANOSCRITTI — INDICE DEI NOM
Effectiveness and Safety of Oro-Dispersible Sildenafil in a New Film Formulation for the Treatment of Erectile Dysfunction: Comparison Between Sildenafil 100-mg Film-Coated Tablet and 75-mg Oro-Dispersible Film
No full textBACKGROUND:
A new oro-dispersible film (ODF) formulation of sildenafil has been developed for the treatment of erectile dysfunction (ED) to overcome the drawbacks that some patients experience when taking the conventional film-coated tablet (FCT).
AIM:
To assess the effectiveness and safety of sildenafil ODF formulation in patients with ED who were using the conventional FCT.
METHODS:
From May 2017 through July 2017, 139 patients with ED were enrolled. Data from penile color-duplex ultrasound, medical history, hormonal evaluation, and patient self-administered questionnaires were collected. All patients were administered sildenafil 100-mg FCT for 4 weeks. Thereafter, they underwent a 2-week washout period and subsequently took sildenafil 75-mg ODF for 4 weeks.
OUTCOMES:
The International Index of Erectile Function (IIEF-15), Hospital Anxiety and Depression Scale (HADS), Patient Global Impressions of Improvement (PGI-I), and Clinician Global Impressions of Improvement (CGI-I) questionnaires were administered and severity of ED was classified as severe (IIEF-15 score ≤ 10), moderate (IIEF-15 score 11-16), or mild (IIEF-15 score = 17-25).
RESULTS:
All patients completed the final protocol. Differences in mean IIEF scores for erectile function, orgasmic function, sexual desire, and intercourse satisfaction were significantly in favor of sildenafil 100-mg FCT, whereas the mean score for overall satisfaction was in favor of sildenafil 75-mg ODF. A significant difference in changes in HADS score was found from washout to final follow-up (mean difference = -0.19; P < .01). For the ODF formulation, the median CGI-I score was 3.5 (interquartile range [IQR] = 2.5-4.5) and the median PGI-I score was 3.0 (IQR = 2.0-4.0). The median action time was 20.0 minutes (IQR = 15.0-30.0) and the median mouth time was 60.0 seconds (IQR = 30.0-120.0).
CLINICAL IMPLICATIONS:
The ODF formulation of a widely known drug, with the same safety and effectiveness of the FCT, was better appreciated by patients in overall satisfaction.
STRENGTHS AND LIMITATIONS:
This is the first clinical trial to assess the efficacy of a new formulation of sildenafil in patients with ED. The limitations of the study are related to the methodology used: it was not a case-control study and the patients were not drug-naïve for ED treatment. Therefore, only the "additional" side effects of the ODF formulation compared with FCT are reported.
CONCLUSION:
The new ODF formulation is as efficient and safe as the FCT formulation and offers a new choice of treatment to specialists for more precisely tailored therapy. Cocci A, Capece M, Cito G, et al. Effectiveness and Safety of Oro-Dispersible Sildenafil in a New Film Formulation for the Treatment of Erectile Dysfunction: Comparison Between Sildenafil 100-mg Film-Coated Tablet and 75-mg Oro-Dispersible Film. J Sex Med 2017;X:XXX-XXX
Documenti e studi sulla tradizione filosofica medievale. An International Journal on the Philosophical Tradition from Late Antiquity to the Late Middle Ages of the Società Internazionale per lo Studio del Medioevo Latino (S.I.S.M.E.L.) Founded by Francesco Del Punta
No full textThe present volume hosts the proceedings of the conference “A Crossroad between East and West: The Latin Medieval Translations of the Kitāb al-Šifāʾ (Book of the Cure) of Ibn Sīnā (Avicenna)”, which took place in Pisa, Scuola Normale Superiore, on 1-3 July 2015 in the framework of the project “Philosophy on the Border of Civilizations and Intellectual Endeavours: Towards a Critical Edition of the Metaphysics (Ilāhiyyāt of Kitāb al-Šifāʾ) of Avicenna (Ibn Sīnā)”, financed by the European Research Council (ERC Advanced Grant, 2014-2019, www.avicennaproject.eu). Some additional articles (N. Caminada, A. Astesiano, N. Polloni, I. Panzeca) complement the papers first presented at the conference. The decision to devote a conference expressly to the Latin translations of the various parts of Avicenna’s philosophical masterpiece produced during the Middle Ages, and, now, to publish the papers of the meeting in a self-standing volume that deals comprehensively with the topic – in both cases for the first time, to the best of our knowledge – finds its justification in the necessity of approaching this key event of the Arabic-into-Latin transmission of philosophical culture in a comprehensive rather than piecemeal way.
Documenti e studi sulla tradizione filosofica medievale XXVIII, 2017:
Amos Bertolacci, Tommaso Alpina, Introduction — Françoise Hudry, La traduction latine de la Logica Avicennae et son auteur — Silvia Di Vincenzo, Is There a versio vulgata of Avicenna’s Kitāb al-Šifāʾ ? On the Hypothesis of a Double Recension of Kitāb al-Madḫal — Niccolò Caminada, A Latin Translation ? The Reception of Avicenna in Albert the Great’s De praedicamentis — Riccardo Strobino, Avicenna’s Kitāb al-Burhān, II.7 and its Latin Translation by Gundissalinus : Content and Text — Gaia Celli, The Rhetoric Section of the Kitāb al-Šifāʾ : Hermannus Alemannus’ Latin Translation and the Arabic Witnesses — Frédérique Woerther, Citer/traduire. La traduction arabo-latine de la Rhétorique d’Aristote par Hermann l’Allemand et les citations d’al-Fārābī et Averroès — Jules Janssens, The Liber primus naturalium, i.e., the Physics of the Avicenna latinus — Alessia Astesiano, L’inizio di un movimento nella fisica del continuo : Avicenna lettore di Aristotele (Libro della guarigione, Fisica, III, 6) — Cristina Cerami, The De Caelo et Mundo of Avicenna’s Kitāb al-Šifāʾ : An Overview of its Structure, its Goal and its Polemical Background — Silvia Di Donato, Les trois traductions latines de la Météorologie d’Avicenne : notes pour l’histoire du texte — Elisa Rubino, The Commentary of Alfred of Shareshill on the pseudo-Aristotelian De mineralibus — Tommaso Alpina, Al‐Ǧūzǧānī Insertion of On Cardiac Remedies in Avicenna’s Book of the Soul : the Latin Translation as a Clue to his Editorial Activity on the Book of the Cure ? — Aafke van Oppenraay, Avicenna’s Liber de animalibus (‘Abbreviatio Avicennae’). Preliminaries and State of Affairs — Rüdiger Arnzen, Double Translations in the Latin Version of the Metaphysics of Avicenna’s Kitāb al-Šifāʾ — Alfonso Quartucci, Avicenna’s Notion of al-mawḍūʿ al-awwal (‘first subject’) in Ilāhiyyāt, I, 1-2 and its Latin Reception — Amos Bertolacci, The Latin Translation and the Original Version of the Ilāhiyyāt (Science of Divine Things) of Avicenna’s Kitāb al-Šifāʾ — Nicola Polloni, Gundissalinus and Avicenna : Some Remarks on an Intricate Philosophical Connection — Ivana Panzeca, On the Persian Translations of Avicenna’s Ilāhiyyāt — Indice dei manoscritti — Indice dei nom
