126,382 research outputs found
Entre linguistique ey anthropologie. Observations de terrain, modèles d'analyse et expérience d'écriture.
No full textL'introduzione mette a confronto la linguistica e l'antropologia settanta anni dopo l'incontro comune delle due discipline con lo strutturalismo
Perusinis II. Fall: Der Alzheimer Patient R.M. Geschichte, Genealogie und Genetik eines psychiatriehistorischen Falls
No full text1.American Journal of Alzheimer`s Disease and Other Dementias: 2010; 25:189-192 100th anniversary of PERUSINI`S SECOND CASE: PATIENT RM and his KINDRED
Im Jahre 1907 wurde der Münchener Korbmacher RM als ,,Zweifelhafter Fall“ in der damals ,,Königlich Psychiatrischen Klinik“ in München behandelt. Die diesbezüglich 1909 von Alzheimers Assistenten Gaetano Perusini publizierte Kasuistik siedelt den offensichtlichen Symptomausbruch im Jahr 1899 an. Dieser gemutmaßte extrem frühe Krankheitsbeginn (38.Lebensjahr des RM) sowie Perusinis familienanamnestischer Hinweis ,,ein Bruder desselben soll nicht recht gescheut sein“ erforderte intensive Recherche zu Geschichte und Genealogie dieses psychiatriehistorischen Falls, um das eventuelle Vorliegen einer heredofamiliären Form von Morbus Alzheimer mit Beginn im frühen Lebensalter zu diskutieren. Detaillierte Untersuchungen über acht Generationen konnten zwar psychiatrische Auffälligkeiten im Stammbaum des Probanden aufzeigen, aber keinen Nachweis einer autosomal-dominanten Form der “Early-Onset Alzheimer`s Disease“ erbringen.
2.Nervenheilkunde: 2010; 29:850-852 Alzheimer und Perusini: Patient RM und sein Stammbaum 1773-2009
Die ersten vier Fälle der Alzheimerschen Krankheit wurden in Alzheimers histopathologischem Laboratorium von dem italienischen Neuropathologen Gaetano Perusini untersucht. Das Weiterverfolgen von Perusinis Hinweis zur auffälligen Psychopathologie des Bruders des RM zeigt noch 1923 die identische differentialdiagnostische Überlegung „Arteriosklerose“ wie bereits 1907 beim Probanden selbst. Das Nachvollziehen der damals angewandten relevanten Untersuchungsmethoden zur Sicherung der Verdachtsdiagnose „Progressive Paralyse“ weist erhebliche Ungenauigkeiten in der Dokumentation auf, so dass verschiedene Differentialdiagnosen zu diskutieren sind. Kurz vor ihrem Tod konnte eine APOE-Genotypisierung der gemäß nervenärztlicher Diagnose an dementiellem Syndrom erkrankten Enkeltochter von Perusinis II.Fall durchgeführt werden. Die Genotypisierung konnte das Vorliegen einer autosomal-dominanten Form des Morbus Alzheimer mit frühem Beginn nicht belegen.
3.Nervenarzt: 2011; 82:363-368
La malattia di Alzheimer-Perusini: Zum 100. Jahrestag der Publikation Gaetano Perusinis
Die Arbeit zielt ab auf Honorierung der Verdienste des Wissenschaftlers Gaetano Perusini (1879-1915). Durch seine genau ein Jahrhundert zurückliegende Veröffentlichung ,,Über klinisch und histologisch eigenartige psychische Erkrankungen des späteren Lebensalters“ kann er als Wegbereiter für das moderne Konzept des altersunspezifischen Beginns der Alzheimerschen Krankheit gelten. Gaetano Perusini arbeitete wissenschaftlich zusammen mit Ugo Cerletti, Alois Alzheimer, Franz Nissl sowie Emil Kraepelin und war beteiligt an der Herausgabe der ,,Folia Neurobiologica“. In seinem persönlichen Schicksal spiegelt sich die Tragik des 1.Weltkrieges: An den Folgen seiner Verwundung durch einen Granatsplitter verstarb Gaetano Perusini im Alter von nur 36 Jahren
L' elisir d'amore : melodramma in due atti
No full textposto in musica dal maestro Gaetano DonizettiVorlageform des Erscheinungsvermerks: Milano presso Gio. Ricordi dirimpetto all'I. R. Teatro alla Scala, Firenze presso Ricordi e Co. Parigi presso L. Launer. Londre presso T. Boosey e Co
Le sens de l'événement
No full textL'introduzione analizza il concetto di evento in chiave multidisciplinare e ne approfondisce l'evoluzione in prospettiva diacronica
A lexicon for Italian cinema: A conversation about history, theory and critique
No full textThis article represents the outcome of a round table organized and conducted by Giacomo Tagliani about the Lessico del cinema Italiano/Lexicon of Italian Cinema (2014–2016). This research and editorial project comprises three volumes and 21 entries that address the history of Italian cinema through an original and challenging approach, namely to detect a list of conceptual clusters able to provide new perspectives over the heritage of Italian films. In this refined version, the authors who took part in that round table, that is, Roberto De Gaetano (also editor of the volumes), Massimiliano Coviello, Luca Venzi and Francesco Zucconi, outline their involvement in the research project, their specific methodological references, their peculiar vision of the history of Italian cinema and eventually their point of view onto its current situation. This written conversation offers a broad survey of Lessico’s key aspects and addresses important methodological, theoretical and critical issues, trying to establish an interdisciplinary dialogue among different fields of studies
Class of invariants for the two-dimensional time-dependent Landau problem and harmonic oscillator in a magnetic field
No full textAbstract: We consider an isotropic two-dimensional harmonic oscillator with arbitrarily time-dependent mass M(t) and frequency Omega(t) in an arbitrarily time-dependent magnetic field B(t). We determine two commuting invariant observables (in the sense of Lewis and Riesenfeld) L, I in terms of some solution of an auxiliary ordinary differential equation and an orthonormal basis of the Hilbert space consisting of joint eigenvectors φ λ of L, I. We then determine time-dependent phases α_λ (t) such that the ψ_λ = e^[iα_λ] φ_λ are solutions of the time-dependent Schroedinger equation and make up an orthonormal basis of the Hilbert space. These results apply, in particular, to a two-dimensional Landau problem with time-dependent M, B, which is obtained from the above just by setting Omega(t) ≡ 0. By a mere redefinition of the parameters, these results can be applied also to the analogous models on the canonical non-commutative plane
Improving nonlinear search with Self-Organizing Maps - Application to Magnetic Resonance Relaxometry
No full textQuantification of myelin in vivo is crucial for the understanding of neurological diseases, like multiple sclerosis (MS). Multi-Component Driven Equilibrium Single Pulse Observation T1 and T2 (mcDESPOT) is a rapid and precise method for determination of the longitudinal and transverse relaxation times in a voxel wise fashion. Briefly, mcDESPOT couples sets of SPGR (spoiled gradient-recalled echo) and bSSFP (fully balance steady-state free precession) data acquired over a range of flip angles (α) with constant interpulse spacing (TR) to derive 6 parameters (free-water T1 and T2, myelin-associated water T1 and T2, relative myelin-associated water volume fraction, and the myelin-associated water proton residence time) based on water exchange models. However, this procedure is computationally expensive and extremely difficult due to the need to find the best fit to the 24 MRI signals volumes in a search of nonlinear 6 dimensional space of model parameters. In this context, the aim of this work is to improve mcDESPOT efficiency and accuracy using tissue information contained in the sets of signals (SPGR and bSSFP) acquired. The basic hypothesis is that similar acquired signals are referred to tissue portions with close features, which translate in similar parameters. This similarity could be used to drive the nonlinear mcDESPOT fitting, leading the optimization algorithm (that is based on a stochastic region contraction approach) to look for a solution (i.e. the 6 parameters vector) also in regions defined by previously computed solutions of others voxels with similar signals. For this reason, we clustered the sets of SPGR and bSSFP using the neural network called Self Organizing Map (SOM), which uses a competitive learning technique to train itself in an unsupervised manner. The similarity information obtained from the SOM was then used to accordingly suggest solutions to the optimization algorithm. A first validation phase with in silico data was performed to evaluate the performances of the SOM and of the modified method, SOM+mcDESPOT. The latter was further validated using real magnetic resonance images. The last step consisted of applying the SOM+mcDESPOT to a group of healthy subjects ( ) and a group of MS patients ( ) to look for differences in myelin-associated water fractions values between the two groups. The validation phases with in silico data verified the initial hypothesis: in more the 74% of the times, the correct solution of a certain voxel is in the space dictated by the cluster which that voxel is mapped to. Adding the information of similar solutions extracted from that cluster helps to improve the signals fitting and the accuracy in the determination of the 7 parameters. This result is still present even if the data are corrupted by a high level of noise (SNR=50). Using real images allowed to confirm the power of SOM+mcDESPOT underlined through the in silico data. The application of SOM+mcDESPOT to the controls and to the MS patients allowed firstly obtaining more feasible results than the traditional mcDESPOT. Moreover, a statistically significant difference of the myelin-associated water fraction values in the normal appearing white matter was found between the two groups: the MS patients, in fact, show lower fraction values compared to the normal subjects, indicating an abnormal presence of myelin in the normal appearing white matter of MS patients. In conclusion, we proposed the novel method SOM+mcDESPOT that is able to extract and exploit the information contained in the MRI signals to drive appropriately the optimization algorithm implemented in mcDESPOT. In so doing, the overall accuracy of the method in both the signals fitting and in the determination of the 7 parameters improves. Thus, the outstanding potentiality of SOM+mcDESPOT could assume a crucial role in improving the indirect quantification of myelin in both healthy subjects and patient
Savi Gaetano
No full textBotanico: Savi, Gaetano (1769-1844).
Professore di botanica e prefetto dell\u27Orto botanico dell\u27Università di Pisa.
Titolo manoscritto sul recto.
Incollata su carta 55 x 34 mm.
1 incisione? ; 48 x 28 mm.
Vai alla scheda bibliografica: https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99001522096020604
Marriage record of Ciccarello, Gaetano and Grana, Epifania
No full textMarriage license for Gaetano Ciccarello and Epifania Grana. L. Leblanc was the officiant
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