161,418 research outputs found
Paediatric Patient with Multiple Sclerosis and High Disease Activity
No full textWe describe a boy with first symptoms of childhood multiple sclerosis (MS) at the age of 11 years. The diagnosis MS was established after the second attack and a disease-modifying therapy was started with glatiramer acetate (Copaxone (R)). Due to high frequency of relapses and a progressing lesion load in cerebral MRI a conversion to interferon beta-1b (Betaferon (R)) was initiated and well tolerated. After a short stable period of disease further progression of MS has now occurred
Pediatric multiple sclerosis (encephalomyelitis disseminata)
No full textMultiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system of unknown etiology normally affecting young adults. Approximately 3-5% of MS patients have onset before the age of 16 (pediatric MS). Neurological deficiencies can occur in multifocal localisations. McDonald's criteria include the dissemination in space and time of the disease activity. Symptoms include, for example, visual dysfunction and sensory or motor impairments. The most frequent clinical manifestation in the pediatric group is a relapsing-remitting disease course, with a milder course of disease and a lower rate of progression when compared to adult MS. Typical diagnostic findings are periventricular lesions of the white matter, oligoclonal bands in the cerebrospinal fluid and delayed evoked potentials. Relapses are treated with high-dose methylprednisolone. Prophylactic, immunomodulative therapies as suggested for adult MS patients are also used for children
NTP-binding properties of the blue-light receptor YtvA and effects of the E105L mutation
No full textTryptophan fluorescence in the Bacillus subtilis phototropin-related protein YtvA as a marker of interdomain interaction
No full textListening to the blue: the time-resolved thermodynamics of the bacterial blue-light receptor YtvA and its isolated LOV domain
No full textOn the motivational primacy of the individual self: “I” is stronger than “We”
No full textThe self-concept is dynamic, with momentary definition shifting from a representation of self as a unique and independent social agent to an undifferentiated and interchangeable group member. Indeed, the individual self and collective self are fundamental components of the self-concept, with each being important and meaningful to human experience. However, are those selves equally important and meaningful? We review a program of research empirically testing three competing hypotheses that suggests that the motivational core of human experience is (a) the individual self, (b) the collective self, or (c) determined by contextual factors that make a given self momentarily accessible. The research furnished unanimous and consistent evidence that the individual self is the motivationally primary form of self-definition
Prof. Th. W. Adorno and the author Hans Erich Nossack.
No full textProf. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB
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