1,721,029 research outputs found
Atypical Anorexia in a Male Patient Accompanied by Strong Obsessive-compulsive Symptoms Successfully Treated with Naltrexone
No full textWe present a patient diagnosed with atypical anorexia accompanied by mainly food intake-related OCD-like symptoms who failed to respond to clomipramine, risperidone, fluoxetine and olanzapine treatment, cognitive behavioural therapy (CBT) and psychodynamic psychotherapy. Naltrexone at a dose of 50 mg/d was added to the current medication consisting of fluoxetine and olanzapine, which resulted in a significant reduction of obsessive-compulsive symptoms as measured by Yale-Brown obsessive-compulsive scale (Y-BOCS) after 8 weeks into naltrexone treatment. The patient's eating behaviour normalised, resulting in an increased body mass index and substantial improvement in his quality of life
Elevated plasma homocysteine in patients with renal failure suffering from restless legs syndrome
No full textPredictors of symptomatic remission in first-episode psychosis outpatients treated with quetiapine: A naturalistic study
No full textObjectives. The aim of this naturalistic study was to assess course and predictors of symptomatic remission in outpatients with first-episode psychosis during quetiapine monotherapy. Methods. In 131 outpatients presenting with first-episode psychosis, socio-demographic and clinical variables including PANSS-8 and CGI-S scores were compared at baseline and follow-up between the subgroups with and without symptomatic remission during 12 weeks of flexible-dose treatment with quetiapine. Results. Logistic regression revealed a low degree of negative symptoms at baseline, younger age, shorter duration of psychotic episode, early treatment response, and the absence of concomitant diseases as predictors for symptomatic remission whereas general disease severity, PANSS-8 total score, gender, alcohol or substance abuse had no predictive value. Conclusions. Our study underlines the predictive value of early treatment response and a low degree of negative symptoms in outpatients with first-episode psychosis. It also confirms the usability of the symptomatic remission criterion as a cross-sectional threshold criterion in clinical practice
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Effect of copy number variant burden on Global Assessment of Functioning in schizophrenia
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