1,721,020 research outputs found
The Potential of Form. Assessing the transformative potential of existing buildings in post-functional Europe
Full text linkL'abstract è presente nell'allegato / the abstract is in the attachmen
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma
No full textc-MET is the membrane receptor for hepatocyte growth factor (HGF), also known as scatter factor or tumor cytotoxic factor, a mitogenic growth factor for hepatocytes. HGF is mainly produced by cells of mesenchymal origin and it mainly acts on neighboring epidermal and endothelial cells, regulating epithelial growth and morphogenesis. HGF/MET signaling has been identified among the drivers of tumorigenesis in human cancers. As such, c-MET is a recognized druggable target, and against it, targeted agents are currently under clinical -investigation. c-MET overexpression is a common event in a wide range of human malignancies, including gastric, lung, breast, ovary, colon, kidney, thyroid, and liver carcinomas. Despite c-MET overexpression being reported by a large majority of studies, no evidence for a c-MET oncogenic addiction exists in hepatocellular carcinoma (HCC). In particular, c-MET amplification is a rare event, accounting for 4%-5% of cases while no mutation has been identified in c-MET oncogene in HCC. Thus, the selection of patient subgroups more likely to benefit from c-MET inhibition is challenging. Notwithstanding, c-MET overexpression was reported to be associated with increased metastatic potential and poor prognosis in patients with HCC, providing a rationale for its therapeutic inhibition. Here we summarize the role of activated HGF/MET signaling in HCC, its prognostic relevance, and the implications for therapeutic approaches in HCC
Desiging the Future of the Past. A survey across the contemporary international debate
Full text linkHow to preserve (or not) what we have inherited is a critical contemporary issue that significantly influences the shaping of a sustainable and desirable future. In a world grappling with the challenge of conserving our cultural heritage for the years to come, the boundaries defining what constitutes heritage have grown increasingly nuanced.
This booklet delves into the ongoing international discourse surrounding the preservation (or not) of the built legacy. By examining how even unacknowledged aspects of our inheritance play an integral role in the broader conversation, this publication offers insights into the evolving perspectives shaping the potential futures of our built legacy.
This volume collects the outcomes of the International Seminar “Designing the Future of the Past,” held on 17-18th February 2022 in Turin. The event was conducted in collaboration with the Doctoral programs in “Architecture: History and Project” and featured the participation of the PhD program in “Architectural and Landscape Heritage” at Politecnico di Torino. This intensive seminar served as an integral component of the DASP PhD Course titled “Designing the Future of the Past” for the academic year 2022-2023
Insta-Turin: Revising the notion of space, community and proximity in the contemporary city through Instagram social urban data
No full textCo-productive Energy Landscape Project: Borgo Monteruga
Full text linkAssuming that an agricultural landscape is an energetic solar landscape, the article describes the premises and the strategy for the regeneration of Borgo Monteruga in Salento, a region known in ancient times for producing lamp oil. After becoming an agricultural site dedicated exclusively to oil production for food purposes, it is now wholly unproductive due to the spread of Xylella Fastidiosa. The absence of unequivocal legislation on agrivoltaics and the need to identify a productive layout that could reactivate and renew the site led the owner to appoint a third-party research institution to determine the most appropriate strategy for the economic regeneration of this non-productive landscape. The method proposed for pursuing the design of a new multifunctional landscape is grounded in the historical reading of the landscape. The visual essay consists of a timeline divided into four sections corresponding to four landscapes. Each section describes how the changing demand for energy, local and supralocal, has modified the actions imprinted on this solar landscape. The last section presents the project scenario reconciling two energy landscapes perceived as inconsistent into a co-productive energy landscape, assuming the historical analysis as design support
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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