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Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis.
No full textBackground/Aims: Portal vein thrombosis in patients with liver cirrhosis is usually associated to hepatocellular
carcinoma. Clinical presentation of non-neoplastic portal vein thrombosis (PVT) in cirrhotic patients has not been
specifically studied and risk factors of PVT in this group of patients are still poorly understood.
Methods: We studied all patients with PVT and liver cirrhosis admitted to our Unit from January 1998 to December
2002. They were paired (by gender, age and Child-Pugh score) to a group of cirrhotic patients without PVT and
screened for acquired and inherited thrombophilic risk factors. These factors together with the site of thrombosis and
the severity of the liver disease were correlated to the clinical presentation of PVT.
Results: Out of a total of 701 cirrhotic patients admitted to our hospital and routinely screened with Doppler
ultrasound, 79 (11.2%) were found to have PVT. Of these, 34 (43%) were asymptomatic and 45 (57%) were
symptomatic (31 presented with portal hypertensive bleed and 14 with abdominal pain, 10 of whom had intestinal
infarction). Mesenteric vein involvement was never asymptomatic and lead to intestinal ischemia or infarction. Most
patients were in class Child-Pugh B and C. Among thrombophilic risk factors studied only the mutation 20210 of the
prothrombin gene resulted independently associated to PVT.
Conclusions: Portal vein thrombosis may be completely asymptomatic in patients with liver cirrhosis; however in
more than half of cases presents with life-threatening complications such as gastrointestinal haemorrhage and
intestinal infarction. Cirrhotic patients with PVT usually have an advanced liver disease and the presence of the
mutation 20210 of the prothrombin gene increases more than fivefold the risk of PVT
Acute portal and mesenteric thrombosis: unusual presentation of cytomegalovirus infection
No full textIncreased plasma prothrombin concentration in cirrhotic patients with portal vein thrombosis and prothrombin G20210A mutation.
No full text.Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis. J Hepatol. 2004; 40(5):736-41.
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A new JAK2 gene mutation in patients with polycythemia vera and splanchnic vein thrombosis.
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