11,860 research outputs found
Il Finanziamento Pubblico alle Nuove Imprese dei Servizi ICT: scenario e prospettive future
No full textDistribution of Al, Ca, Fe and Mg in weathering extracts from Campanian Ignimbrite (yellow facies)
No full textA study was started aiming at assessing the pedogenic potential of zeolitized tuffs as possible substrates to soil formation, especially for soil rebuilding in degraded lands. This paper deals with Ca, Al, Mg and Fe distribution in leachates obtained by a sequence of experimental weathering cycles of Campanian Ignimbrite (yellow facies) by water (W) and Na-humate (Na-Hu). The cation amounts were Al>Ca>Mg>Fe in W and Ca>Al>Mg>Fe in Na-Hu extracts, the latter being more efficient. © 2008 Elsevier B.V. All rights reserved
Pharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. I. Frontal cortex
No full textPharmacological characterization of D1 and D2 dopamine receptors in rat limbocortical areas. II. Dorsal hippocampus
No full textIssues concerning soils treated with wastewater: Pedotechnical management with zeolitized tuffs as an option for turning N and P pollutants into potential fertilizers
No full textWe studied the effects of amendment with zeolitized tuffs (ZT) in recovering nitrogen and phosphorus as potential plant nutrients in soils treated with wastewater (WW). The surface horizon of two contrasting soils (a sandy, alkaline Entisol, and a sandy-loam, sub-acidic Alfisol), was pedotechnically managed with different ratios of Neapolitan Yellow Tuff (NYT) and a clinoptilolite bearing tuff (ZCL). It was then exposed to repeated treatments with 'dirty' municipal wastewater (DMW). Results showed that the presence of ZTs had several favorable effects. As concerns the aspect connected with the investigation into the supernatant/soil solution, total N and total P decreased sharply in the supernatant as ZT content in soil/zeolite samples increased. Large quantities of nitrate were removed from the solution, most probably via bio-chemical reaction. Investigation of the soil/zeolite samples after twelve consecutive treatment cycles showed that the concentration of the essential plant macronutrients N and P increased as ZT content increased. Overall, the ZTs added directly to the poorly-resilient soils appeared to be a useful amendment in reducing the pollutants load caused by irrigation with untreated wastewater. It also played a positive role in pedotechnique strategies, improving both the natural intrinsic soil resilience and soil functionality
Calcium signals induced by extracellular application of NAADP in developing neurons and glial cells
No full textSolutions for critical raw materials under extreme conditions: A review
No full textIn Europe, many technologies with high socio-economic benefits face materials requirements that are often affected by demand-supply disruption. This paper offers an overview of critical raw materials in high value alloys and metal-matrix composites used in critical applications, such as energy, transportation and machinery manufacturing associated with extreme working conditions in terms of temperature, loading, friction, wear and corrosion. The goal is to provide perspectives about the reduction and/or substitution of selected critical raw materials: Co, W, Cr, Nb and Mg. © 2017 by the authors
Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts.
No full textDi Napoli P, Taccardi AA, Grilli A, De Lutiis MA, Barsotti A, Felaco M, De Caterina R. Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc Res. 2005 Jun 1;66(3):462-71. Epub 2005 Mar 2.
Laboratory of Experimental Cardiology, Department of Clinical Sciences and Bioimaging, and Center of Excellence of Aging, G. d'Annunzio University, Chieti, Italy.
OBJECTIVE: Due to reported modulatory effects of statins on nitric oxide synthase (NOS) expression, we tested the hypothesis of protective effects of in vivo chronic treatment with rosuvastatin, a novel 3-hydroxy-3-methyl-glutaryl coenzyme A-reductase inhibitor, on ischemia-reperfusion injury, and investigated mechanisms involved.
METHODS: After 3 weeks of in vivo treatment with rosuvastatin (0.2-20 mg/kg/day) or placebo, excised hearts from Wistar rats were subjected to 15 min global ischemia and 22-180 min reperfusion. We evaluated creatine-phosphokinase and nitrite levels in the coronary effluent, heart weight changes, microvascular permeability (extravasation of fluoresceine-labeled albumin), ultrastructural alterations, and the expression of endothelial (e) and inducible (i) nitric oxide synthase (NOS) (by reverse-transcription polymerase chain reaction and Western blotting).
RESULTS: Rosuvastatin 0.2 and 2 mg/kg/day significantly reduced myocardial damage and vascular hyperpermeability, concomitant with a reduction in endothelial and cardiomyocyte lesions. At 2 mg/kg/day, rosuvastatin significantly increased eNOS mRNA and protein compared with untreated hearts, and conversely decreased iNOS mRNA and protein, as well as nitrite production after ischemia-reperfusion. The addition of the NOS inhibitor N(omega)-nitro-L-arginine methylester (L-NAME, 30 micromol/L) significantly reduced cardioprotection against ischemia-reperfusion.
CONCLUSIONS: Chronic treatment with rosuvastatin before ischemia reduces ischemia-reperfusion injury and prevents coronary endothelial cell and cardiomyocyte damage by NO-dependent mechanisms
Study on the Mg-Li-Zn ternary alloy system with improved mechanical properties, good degradation performance and different responses to cells
No full textNovel Mg-(3.5, 6.5wt%)Li-(0.5, 2, 4wt%)Zn ternary alloys were developed as new kinds of biodegradable metallic materials with potential for stent application. Their mechanical properties, degradation behavior, cytocompatibility and hemocompatibility were studied. These potential biomaterials showed higher ultimate tensile strength than previously reported binary Mg-Li alloys and ternary Mg-Li-X (X=Al, Y, Ce, Sc, Mn and Ag) alloys. Among the alloys studied, the Mg-3.5Li-2Zn and Mg-6.5Li-2Zn alloys exhibited comparable corrosion resistance in Hank's solution to pure magnesium and better corrosion resistance in a cell culture medium than pure magnesium. Corrosion products observed on the corroded surface were composed of Mg(OH)2, MgCO3 and Ca-free Mg/P inorganics and Ca/P inorganics. In vitro cytotoxicity assay revealed different behaviors of Human Umbilical Vein Endothelial Cells (HUVECs) and Human Aorta Vascular Smooth Muscle Cells (VSMCs) to material extracts. HUVECs showed increasing nitric oxide (NO) release and tolerable toxicity, whereas VSMCs exhibited limited decreasing viability with time. Platelet adhesion, hemolysis and coagulation tests of these Mg-Li-Zn alloys showed different degrees of activation behavior, in which the hemolysis of the Mg-3.5Li-2Zn alloy was lower than 5%. These results indicated the potential of the Mg-Li-Zn alloys as good candidate materials for cardiovascular stent applications. Statement of significance: Mg-Li alloys are promising as absorbable metallic biomaterials, which however have not received significant attention since the low strength, controversial corrosion performance and the doubts in Li toxicity. The Mg-Li-Zn alloy in the present study revealed much improved mechanical properties higher than most reported binary Mg-Li and ternary Mg-Li-X alloys, with superior corrosion resistance in cell culture media. Surprisingly, the addition of Li and Zn showed increased nitric oxide release. The present study indicates good potential of Mg-Li-Zn alloy as absorbable cardiovascular stent material.Accepted Author ManuscriptBiomaterials & Tissue Biomechanic
Modeling pedogenization of zeolitized tuffs: effects of water and phenolic substances on weathering rates of the Campanian Ignimbrite (yellow facies)
No full textAn experimental pedology research project, based on a ‘‘process-system’’
pedogenetic model, was initiated to investigate the weathering of Phlegraean Yellow Tuff (PYT)
the yellow facies of the Campanian Ignimbrite with phillipsite > chabazite as representative of
the parent rock material as the soil-forming factor. PYT was weathered by water (W) and tannic acid
solutions (TA) at concentrations ranging from 36101 to 36104 mmol l1. The most concentrated TA
solution (36104 mmol l1) showed the greatest extracting efficiency. Na and K were continually
solubilized by W; Al, Ca and Mg contributed to the ionic composition of all the TA supernatants. A
significant dissolution of the amorphous component and an associated decrease of the zeolite content,
especially phillipsite, were noted. The features of PYT weathered outcomes fitted the ‘‘processsystem’’
model very well. PYT showed a pedogenic potential, in being prone to weathering, as well
as in releasing elements of importance for plant settlement and development, such as K, Ca, Mg and
Fe
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