1,721,011 research outputs found
Sustainable Production in the Age of Mass Customization: an Example in the Footwear Industry
No full textValidation of a Virtual Prototyping Tool for Uniaxial Flexible Parts
No full textModern 3D CAD systems piping modules are powerful tools for modeling solids as rigid bodies but neglect their physical behavior. On the contrary, Virtual Prototyping requires the realistic representation of components especially for flexible parts. A finite element based system is presented to model flexible uniaxial components like hoses, wires and cables on the base of mounting and loading conditions. It interacts with a 3D CAD system in order to generate geometries and assess optimal solutions, interferences and overall stress condition.
The proposed system requires an adequate validation in order to be efficiently integrated in the design workflow. The first investigated aspect was material characterization. Since metallic reinforced elastomeric hoses show non linear behavior, a simplified model based on mean section characteristics was drawn from numeric models and experimental measurements. Then, some significant configurations have been physically reproduced on a test bed, acquired through a Reverse Engineering system and compared with simulation outputs of identical setups.
The approach, the validation activity, results and some meaningful application examples are presented in the paper
The design process of additively manufactured mesoscale lattice structures: A review
Full text linkThis review focuses on the design process of additively manufactured mesoscale lattice structures (MSLSs). They are arrays of three-dimensional (3D) printed trussed unit cells, whose dimensions span from 0.1 to 10.0 mm. This study intends to detail the phases of the MSLSs design process (with a particular focus on MSLSs whose unit cells are made up of a network of struts and nodes), proposing an integrated and holistic view of it, which is currently lacking in the literature. It aims at guiding designers' decisions with respect to the settled functional requirements and the manufacturing constraints. It also aims to provide an overview for software developers and researchers concerning the design approaches and strategies currently available. A further objective of this review is to stimulate researchers in exploring new MSLSs functionalities, consciously considering the impact of each design phase on the whole process, and on the manufactured product
Supporting product innovation in uncertainuty conditions: a UsDSP based decision making approach
No full textThe influence of slicing parameters on the multi-material adhesion mechanisms of FDM printed parts: an exploratory study
Full text linkThe potentiality of the Fused Deposition Modeling (FDM) process for multi-material printing has not yet been thoroughly explored in the literature. That is a limitation considering the wide diffusion of dual extruders printers and the possibility of increasing the number of these extruders. An exploratory study, based on tensile tests and performed on double-material butt-joined bars, was thus conceived; the aim was to explore how the adhesion strength between 3 pairs of filaments (TPU-PLA, PLA-CPE, CPE-TPU) is influenced by the material printing order, the type of slicing pattern used for the layers at the interface, and the infill density of the layers below the interface. Results confirm the effectiveness of mechanical interlocking strategies in increasing the adhesion strength even when thermodynamic and diffusion mechanisms of adhesion are not robust enough. Besides, thermal aspects also demonstrated to play a relevant role in influencing the performance of the interface
A step-based framework to combine creativity, project management and technical development in industrial innovation
No full textThe intracellular antibody capture technology (IACT): Towards a consensus sequence for intracellular antibodies
No full textWe describe the application of an intracellular antibody capture technology (IACT) as a generic in vivo selection procedure for isolating intracellular antibodies or ICAbs. IACT was applied to the de novo selection of functional ICAbs against the microtubule-associated protein TAU, found in neurofibrillary lesions of Alzheimer's disease brains. A panel of 17 different ICAbs was created which bind TAU inside cells and the epitopes recognized by the selected ICAbs have been determined by an in vivo epitope mapping procedure. Finally, sequence analysis showed that the IACT-derived ICAbs are characterized by a common signature of conserved amino acid residues, suggesting that the IACT naturally selects a sort of "captured consensus sequence" for intracellular antibodies. The development of IACT, together with the possibility of scaling up in a high throughput and automated format, makes IACT a new enabling tool for target validation in functional genomics and global proteomics
In vivo expression of anti-tau intrabodies selected by the intrabody trap technology (ITT).
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