1,721,039 research outputs found
Jet evolution in steep spectrum radio quasars: A multiwavelength study
No full textThanks to the Fermi γ-ray satellite, it is now confirmed that Misaligned Active Galactic Nuclei (MAGN), i.e. radio galaxies and steep spectrum radio quasars, are a new class of GeV emitters. In this work we present the first γ-ray and multiwavelength study of the two steep spectrum radio quasars, i.e. 3C 207 and 3C 380, belonging to the MAGN sample. From the γ -ray variability study we estimate the physical size of the zone where high-energy photons are dissipated: for both sources this region should be very compact, not larger than 0.05 pc. As a successive step, we build multiwavelength light curves of 3C 207 and 3C 380 to search for possible simultaneous outbursts in different wavebands with the aim of localizing the compact emitting region. This is an important issue with strong impact on theoretical models: indeed, knowing where highenergy photons are dissipated (at sub-pc or pc-scale) provides information on the nature of the seed photons involved in the production of the GeV radiation. © Owned by the authors, published by EDP Sciences, 2013
Targeting HSV amplicon vectors
No full textSeveral techniques have been developed to deliver DNA directly into mammalian cells, spanning in difficulty from simple mixing procedures to complex systems requiring expensive equipment. Viral vectors have proven able to deliver genes into mammalian cells with high efficiency and low toxicity. In particular, herpes simplex virus type-1 (HSV-1) amplicon vectors are well suited for gene transfer studies as they can infect many cell types, both non-dividing and dividing, have a large transgene capacity and are easy to manipulate. For some applications, it may be desirable to target gene delivery to specific cell populations or to transduce normally non-susceptible cells. This can be achieved by modifying one or more of the glycoproteins found in the viral envelope. Glycoprotein C (gC) has a well-characterized heparan sulfate binding domain (HSBD) necessary for HSV binding to cells. Replacing this region with unique ligands can result in less efficient binding to natural target cells and increase binding to cells which express receptors for these ligands. A method to retarget amplicon vectors by replacing gC HSBD with a model ligand, the hexameric histidine-tag, is described, as well as means to evaluate the binding of modified vector as compared to wild-type virus to cells with or without the appropriate receptor, in this case, a his-tag pseudo-receptor. This protocol demonstrates increased binding of modified virus to receptor-positive cells (at levels greater than wild-type) with no loss of infectivity. Retargeted vectors can provide an additional tool for increasing the efficiency of gene delivery to specific cell type
JETS AND OUTFLOWS IN RADIO GALAXIES: IMPLICATIONS FOR AGN FEEDBACK
No full textOne of the main debated astrophysical problems is the role of the AGN
feedback in galaxy formation. It is known that massive black holes have a
profound effect on the formation and evolution of galaxies, but how black holes
and galaxies communicate is still an unsolved problem. For Radio Galaxies,
feedback studies have mainly focused on jet/cavity systems in the most massive
and X-ray luminous galaxy clusters. The recent high-resolution detection of
warm absorbers in some Broad Line Radio Galaxies allow us to investigate the
interplay between the nuclear engine and the surrounding medium from a
different perspective. We report on the detection of warm absorbers in two
Broad Line Radio Galaxies, 3C 382 and 3C 390.3, and discuss the physical and
energetic properties of the absorbing gas. Finally, we attempt a comparison
between radio-loud and radio-quiet outflows
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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