1,720,974 research outputs found
Cardiolipin fingerprinting of leukocytes by MALDI-TOF/MS as a screening tool for Barth syndrome
Get PDFBarth syndrome (BTHS), an X-linked disease associated with cardioskeletal myopathy, neutropenia, and organic aciduria, is characterized by abnormalities of cardiolipin (CL) species in mitochondria. Diagnosis of the disease is often compromised by lack of rapid and widely available diagnostic laboratory tests. The present study describes a new method for BTHS screening based on MALDI-TOF/MS analysis of leukocyte lipids. This generates a "CL fingerprint" and allows quick and simple assay of the relative levels of CL and monolysocardiolipin species in leukocyte total lipid profiles. To validate the method, we used vector algebra to analyze the difference in lipid composition between controls (24 healthy donors) and patients (8 boys affected by BTHS) in the high-mass phospholipid range. The method of lipid analysis described represents an important additional tool for the diagnosis of BTHS and potentially enables therapeutic monitoring of drug targets, which have been shown to ameliorate abnormal CL profiles in cells
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
El uso de las mentes : ontología para una política de la vida ecológica.
Get PDFThe research on the production of political “qualified” or “unqualified” life forms was at the centre of the philosophical and sociological analytic of the last decades. In this frame, the concept of biopolitics revolutionised the topography and the analytical tools of the political as well as of the social relations and systems, allowing thus to make new connections and analogy visible. To such an analytical abundance, however, does not correspond a comparable reflection about praxis of emancipation from and in the biopolitical relations. In this paper I will show the theoretical and practical potential of the concept of use and its importance for the definition of an ontology of the ecological life, that could be ethical and political, in so much as this concept could allow a suspension and neutralization of the biopolitical dispositifs. In this perspective the recent works of Giorgio Agamben and Ottavio Marzocca are particularly important. Both authors – in different ways – adopt the concept of use in order to think and to live a new way to be in the world, which unlocks the bios from the biopolitical and bioeconomic cages of our time.El análisis filosófico, politológico y sociológico de las últimas décadas ha hecho hincapié en la búsqueda de la producción de formas de vida políticamente “cualificadas” o “descalificadas”. En este marco, el concepto de biopolítica ha revolucionado la topografía y los instrumentos de las facetas analíticas de lo político, así como de las relaciones y de los sistemas sociales. Sin embargo, a esta riqueza analítica no se ha ajustado otra reflexión tan rica acerca de las praxis de emancipación a partir de y en las relaciones biopolíticas. En este artículo queremos mostrar las potencialidades teoréticas y prácticas del concepto de uso, y su importancia para la definición de una ontología para una vida ecológica, que sea al mismo tiempo ética y política, si y cuando este concepto permite la superación y la desactivación de los dispositivos biopolíticos dominantes. Desde esta perspectiva, muy útiles son las recientes obras de Giorgio Agamben y Ottavio Marzocca. Ambos autores –aunque de forma diferente– consideran el concepto de uso como elemento para pensar y vivir una nueva manera de existir en el mundo, que libere al bíos de las jaulas biopolíticas y bioeconómicas de nuestro presente
The use of minds. Ontology for an ecological life policy
Get PDFEl análisis filosófico, politológico y sociológico de las últimas décadas ha hecho hincapié en la búsqueda de la producción de formas de vida políticamente “cualificadas” o “descalificadas”. En este marco, el concepto de biopolítica ha revolucionado la topografía y los instrumentos de las facetas analíticas de lo político, así como de las relaciones y de los sistemas sociales. Sin embargo, a esta riqueza analítica no se ha ajustado otra reflexión tan rica acerca de las praxis de emancipación a partir de y en las relaciones biopolíticas. En este artículo queremos mostrar las potencialidades teoréticas y prácticas del concepto de uso, y su importancia para la definición de una ontología para una vida ecológica, que sea al mismo tiempo ética y política, si y cuando este concepto permite la superación y la desactivación de los dispositivos biopolíticos dominantes. Desde esta perspectiva, muy útiles son las recientes obras de Giorgio Agamben y Ottavio Marzocca. Ambos autores –aunque de forma diferente– consideran el concepto de uso como elemento para pensar y vivir una nueva manera de existir en el mundo, que libere al bíos de las jaulas biopolíticas y bioeconómicas de nuestro presente.The research on the production of political “qualified” or “unqualified” life forms was at the centre of the philosophical and sociological analytic of the last decades. In this frame, the concept of biopolitics revolutionised the topography and the analytical tools of the political as well as of the social relations and systems, allowing thus to make new connections and analogy visible. To such an analytical abundance, however, does not correspond a comparable reflection about praxis of emancipation from and in the biopolitical relations. In this paper I will show the theoretical and practical potential of the concept of use and its importance for the definition of an ontology of the ecological life, that could be ethical and political, in so much as this concept could allow a suspensión and neutralization of the biopolitical dispositifs. In this perspective the recent works of Giorgio Agamben and Ottavio Marzocca are particularly important. Both authors – in different ways – adopt the concept of use in order to think and to live a new way to be in the world, which unlocks the bios from the biopolitical and bioeconomic cages of our time
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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