1,721,071 research outputs found
Spontaneous rupture of the spleen : histologic, immunohistochemical and ultrastructural study
No full textPathological examination in the spleen of an 81-year old female with
hemoperitoneum, hypovolemic shock, anemia, thrombocytopenia and hyperglicemia
revealed the presence of an angiosarcoma. On histological examination,
characteristically the neoplasm was formed by vascular lumina and cystic spaces
into which papillary fronds projected and solid nests. Neoplastic cells had scant
cytoplasm, hyperchromatic, oval or reniform nuclei, with prominent nucleoli. The
necrosis was evident and mitoses were frequent. Immunohistochemical analysis
revealed positivity for endothelial (CD31, CD34) and histiocytic markers (CD68
and lysozyme) and negativity for CD21. Ultrastructural examination also disclosed
a biphasic differentiation, showing the presence of organelles associated with
histiocytic and endothelial differentiation. These findings suggest that this
lesion can be considered a conventional splenic angiosarcoma with focal
histocytic differentiation
Endometrial carcinoma metastatic to the vulva: A case report and review of the literature
No full textVulvar acantholitic squamous carcinoma: a cse report with immunohistochemical and molecular stydy
No full textActivity of lenvatinib plus everolimus combination in a heavily pretreated patient with papillary renal cell carcinoma: a case report
No full textBackground: Papillary renal cell carcinoma (pRCC) represents the second most common histologic subtype of renal cell carcinoma and comprises 2 subtypes. Prognosis for type 2 is associated with poor clinical outcome. Current guidelines are based on phase II trials, phase III trials in patients with clear cell histology, or retrospective data. Case description: To our knowledge, we describe for the first time a case of a patient with heavily pretreated metastatic pRCC who benefited from the combination of lenvatinib plus everolimus for more than 2 years. Conclusion: According to immunohistologic and biological findings in our patient both on primary tumor and liver metastasis, we hypothesize that selected patients with metastatic pRCC, progressed to standard/available treatments (including angiogenic drugs, mTOR inhibitors, and immunotherapy) and dissociated response to everolimus, could benefit from adding lenvatinib to everolimus
Oncocytic mucoepidermoid carcinoma of a submandibular gland: a case report and review of the literature.
Full text linkThis report describes the first recognized case of oncocytic mucoepidermoid carcinoma of a submandibular gland, and emphasizes the role of immunohistochemical study in the correct diagnosis of this tumour. This is only the second case in which this tumour has appeared as a completely cystic lesion. A review of the literature was carried out to clarify the clinical and pathological features of this rare malignancy
Metastatic extragenital neoplasms to the uterus: A clinicopathological study of four cases.
Full text linkThe aim of this study was to elucidate the clinicopathologic features, the
differential diagnostic problems, and the prognostic consequences of patients
with metastatic extragenital malignancies to uterus. The patients with metastatic
extragenital malignancies to the uterus were evaluated. We considered the
metastases in non-genital tract organs at diagnosis of primary neoplasm, the
distribution of the metastases in the uterus, and the presence of concomitant
metastases in other genital and non-genital tract organs. There were four cases
of metastatic extragenital malignancies to the uterus. The breast was the most
frequent primary site (two cases: 50%). The other two primary tumors were
adenocarcinoma of the cecum and malignant melanoma of the skin. The diagnosis was
facilitated by clinical history, revealing the previous primary neoplasm, and by
specific immunohistochemical study. Almost all the patients died from
disseminated disease. Thus, the prognosis of metastatic extragenital malignancies
to the uterus alone or simultaneously to the uterus and other organs of the
genital tract is poor. Thus, the metastases to the uterus and to other organs of
the genital tract can be considered a preterminal event
KRAS: A Druggable Target in Colon Cancer Patients
Full text linkMutations in KRAS are among the most frequent aberrations in cancer, including colon cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule inhibition. Moreover, its elevated affinity to cellular guanosine triphosphate (GTP) has made the design of specific drugs challenging. Indeed, KRAS was considered ‘undruggable’. KRASG12C is the most commonly mutated variant of KRAS in non-small cell lung cancer. Currently, the achievements obtained with covalent inhibitors of this variant have given the possibility to assess the best therapeutic approach to KRAS-driven tumors. Mutation-related biochemical assets and the tissue of origin are expected to influence responses to treatment. Further attempts to obtain mutant-specific KRAS (KRASG12C) switch-II covalent inhibitors are ongoing and the results are promising. Drugs targeted to block KRAS effector pathways could be combined with direct KRAS inhibitors, immunotherapy or T cell-targeting approaches in KRAS-mutant tumors. The development of valuable combination regimens will be essential against potential mechanisms of resistance that may arise during treatment
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