11,777 research outputs found
Microglia and mast cells: two tracks on the road to neuroinflammation.
No full textOne of the more important recent advances in neuroscience research is the understanding that there is extensive communication between the immune system and the central nervous system (CNS). Proinflammatory cytokines play a key role in this communication. The emerging realization is that glia and microglia, in particular, (which are the brain's resident macrophages), constitute an important source of inflammatory mediators and may have fundamental roles in CNS disorders from neuropathic pain and epilepsy to neurodegenerative diseases. Microglia respond also to proinflammatory signals released from other non-neuronal cells, principally those of immune origin. Mast cells are of particular relevance in this context. These immunity-related cells, while resident in the CNS, are capable of migrating across the blood-spinal cord and blood-brain barriers in situations where the barrier is compromised as a result of CNS pathology. Emerging evidence suggests the possibility of mast cell-glia communications and opens exciting new perspectives for designing therapies to target neuroinflammation by differentially modulating the activation of non-neuronal cells normally controlling neuronal sensitization, both peripherally and centrally. This review aims to provide an overview of recent progress relating to the pathobiology of neuroinflammation, the role of microglia, neuroimmune interactions involving mast cells, in particular, and the possibility that mast cell-microglia crosstalk may contribute to the exacerbation of acute symptoms of chronic neurodegenerative disease and accelerate disease progression, as well as promote pain transmission pathways. We conclude by considering the therapeutic potential of treating systemic inflammation or blockade of signaling pathways from the periphery to the brain in such settings.-Skaper, S. D., Giusti, P., Facci, L. Microglia and mast cells: two tracks on the road to neuroinflammation
Romanian alt in a pan-Romance perspective
No full textThis paper confirms Nicolae and Cornilescu’s (2011, 2012) hypothesis that alt ‘other’ can be an existential quantifier and can be part of complex existential quantifiers in combination with the indefinite article, cardinals and vague quantifiers. This creates a number of competing forms (bare alt vs. un alt, alt > Card vs Card > alt, Q > alt vs alt > Q) which interact in a complex fashion with the pronominalizing morphology appearing in nominal ellipsis. The diagnostics applied to Italian altro and Portuguese outro by Brugè and Giusti (2021) are systematically applied to alt in a survey, whose results confirm the same tendencies of speaker preferences found in the other Romance languages: bare alt is favoured onto un alt, alt > Card wins over Card > alt and Q > alt wins over alt Q. This confirms Brugè and Giusti’s hypotheses that complex quantifiers are listed in the lexicon and not freely formed in the syntax. It also favours the hypothesis that QP is above DP and not vice versa
Jornadas Internacionales de Econometría: parte 1
No full textConferenciaVideo donde el decano de la Facultad de Ciencias Económicas, José Luis Giusti, da apertura a las Jornadas Internacionales de Econometría realizadas el día 14 de Agosto del 2014. Da inicio a estas Jornadas Marcos Dal Bianco, representante de BBVA Research, y Laura D’Amat
Correspondence: Laura Kephart and Arthur Stupka
No full textThis 1936 correspondence, between Laura Kephart (Mrs. Horace Kephart) and Arthur Stupka, concerns a possible Kephart Memorial. Horace Kephart (1862-1931) was a noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park. Arthur Stupka (1905-1999) was the first park naturalist to work at the Great Smoky Mountains National Park
Mindscapes: Laura Riding's poetry and poetics /
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Esta tese propõe uma leitura revisionista da poesia contemporânea através do exame do caso de um dos mais esquecidos escritores norte-americanos do século XX: Laura (Riding) Jackson (1901-1991). O objetivo é demonstrar que Riding não apenas possuía uma poética definida e singular, mas que ela permanece uma das instâncias mais extremas e paradoxais do modernismo anglo-americano, a ponto de Riding abandonar a escrita da poesia em 1938. Recorrendo a conceitos de "formação do cânone" bem como às noções de "discurso" e "função do autor", em Foucault, investigo a construção do cânone da poesia moderna anglo-americana, recuperando o contexto e as circunstâncias da ocultação de Riding. Enquanto cubro os "discursos" poéticos em circulação na primeira metade do século XX-o "imagismo" de Pound, a "dissociação da sensibilidade", "impersonalidade" e "tradição" de Eliot, a "unidade orgância" e "ambigüidade" da Nova Crítica-ofereço um panorama crítico de modernismos alternativos sendo articulados à época. Minha intenção é demonstrar que os poemas de Riding são expressões vigorosas de um escritor para quem "a mente pensando se torna a força ativa do poema", para usar a apta formulação de Charles Bernstein. Entre minhas descobertas sobre as várias e complexas razões que levaram à não-canonização de Riding estão a hegemonia da Nova Crítica, o exílio voluntário de Riding da cena literária (onde são feitas ou desfeitas as reputações), sua recusa em ser antologiada, bem como em ser explicada em termos críticos que não os dela. Todos esses fatores, mais a "dificuldade" de sua poesia, contribuíram para fazer de Riding "a maior poeta esquecida da poesia norte-americana", como escreveu Kenneth Rexroth. Ajudado pelos insights de dois importantes críticos de poesia norte-americana, Charles Bernstein e Marjorie Perloff, defendo que a "poesia da mente" de Riding-onde o que está em jogo é que o que pensamos ser a nossa realidade-representa uma mudança radical no paradigma da poética modernista: de uma poesia centrada na imagem para uma poesia centrada na linguagem. Focalizando a experiência consciente e o tempo duracional do pensamento presente em seus poemas, concluo que as "pensagens" de Riding têm o objetivo preciso de constatar um fato universal: enquanto seres humanos e pensantes, estamos numa condição permanente chamada linguagem
A protocol for the Syntax of ‘Other’ in Indefinite Nominal Expressions across Romance Languages
No full textIn Romance languages “other” derives from the Vulgar Latin word alteru(m) (from alter) “another (different) among two/many”:
(1) a. o/ (um) outro amigo Portuguese
b. el/ Ø otro amigo Spanish
c. l’/Un altre amic Catalan
d. l’/Un autre ami French
e. l’/Un altro amico Italian
f. celălalt / (Un) alt prieten Roumanian
“the other/another friend”
and its contribution to the meaning of the noun phrase is related to the context. A noun phrase modified by “other” denotes an entity “which is either different from or additional to some other entity already mentioned or known about.
In the (recent) literature this lexical items is analyzed either as an adjective with functional properties that is merged in a high position inside the extended projection of the noun –it is preceded by a definite or indefinite determiner and it precedes all the other prenominal adjective classes– or as a determiner in indefinite contexts –it appears in a very high position and goes into complementary distribution with the indefinite article (Spanish, (1b))–.
In this chapter we will study, in a comparative perspective, the syntactic and interpretive behavior of “other” in Romance languages represented in (1). We will argue that this lexical item has two different statuses: it is a quantifier, and not a determiner, and also an adjective, as it occurs with many of existential quantifiers. Its status as a quantifier can be found in indefinite contexts (outro amigo (port.); otro amigo (sp.); alt prieten (roum.) “another friend”). In fact, in all these languages it can introduce a subject singular nominal expression (outro homem comprou o jornal (port.); otro hombre compró el periódico (sp.) “another man bought the newspaper”), can appear as complement of the existential verb (havia outro/outros (port.); había outro/otros (sp.)) and can appear in an object position with the elliptical noun (comprou outro (port.)/ compró otro (sp.) “he/she bought another”). Moreover, in those Romance languages in which “other” must be preceded by the indefinite article, the elliptical nouns triggers the obligatory presence of the partitive clitic ne/en:
(2) a. M’estimo més llegir-ne una altra vs. *En vaig veure un últimi
Catalan
b. Je préfère en lire un autre *J'en ai vu un dernier
French
c. Preferisco leggerne un’altra *Ne ho visto un ultimo
Italian
“I prefer to read another” “*I saw a last”
The contrasts in (2), together with other syntactic behavior that we will discuss in the paper show that the indefinite article and “other” form a complex quantifier. We will extend this proposal also in those cases in which “other” combines either with a cardinal “other two” or with an existential (weak) quantifier “many/few other(s)”. The results of these combination show a large overlap across Romance with interesting parametrization which lead us to propose that the complex quantifiers must be listed as such in the lexicon of individual languages, while the hierarchy of Q > Det > Adj is common across Romance (and indeed universal). In those languages such as Italian, in which, for example, altro “other” can precede or follow the cardinal (altri due N/ due altri N “two other N”), the complex quantifier is represented by the order “other > Cardinal” in the inverse order “other” should be analysed as an adjective, as the following contrasts show:
(3) a. Preferisco leggerne altre due
b. *Preferisco leggerne due altre
“I prefer to read two others”
The status of “other” as an adjective can be detected in the definite domain. “Other” behaves as an adjective when it appears preceded by the definite article (o outro amigo (port.); el otro amigo (sp.); l’altre amic (cat.); l’autre ami (fr.); l’altro amico (it.); celălalt prieten (roum.)
Letter, Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869
No full textALS of Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869, about interviewing other first ladies. ALS.Found in:Mss. 65 T97 Additions, Series 1: Mss. Acc. 1993.19 Addition, 186
Heritage tourism: a case study of the Laura Ingalls Wilder Heritage Site at Pepin, Wisconsin
No full textPlan BMany things must be taken into consideration when developing a heritage tourism site. It can be a wonderful opportunity for the community involved to benefit economically and historically. Heritage tourism can keep alive the heritage and traditions of the communities past. When it is discovered that a heritage site exists, the first step is to consult with the community. A site will not succeed without the acceptance and assistance from the community involved. Once the interest is known, the development process can proceed. After determining that there is a heritage tourism site possibility in their area, a commumity must do research to determine the feasibility of the site, what will make it a success, and how to obtain that success. This study will examine a community with a heritage tourism site that has been successful in developing and maintaining it's site. By conducting this study, other communities seeking information for developing their site will have an example and tool to work with. The site chosen for this study is the Laura Ingalls Wilder site in Pepin, Wisconsin. The town is rich with it's heritage associated with Laura Ingalls Wilder. The development and success for this town will be documented through this study. Laura Ingails Wilder is a perfect choice for examining heritage tourism. The author of many American Pioneer books, she has become famous all over the world. In turn all places that she or her family members lived are or are becoming heritage tourism sites. There are older ones that have been in progress for some years, such as the one in Pepin, and there are ones that are being discovered through the popularity of new books written about Laura's family. These communities would benefi greatly from the information this study will produce. Without the bene-fit of this knowledge communities who are unaccustomed to tourism or the way the other Laura Ingalls Wilder sites operate, may make terrible errors in development, tarnishing the site. This may also reflect badly on the other Laura Ingalls Wilder sites. It is important for new Wilder sites to examine all information and know exactly what they are doing when developing the site. If all the Laura Ingalls Wilder sites can benefit from each other's knowledge and experience it will greatly increase the market for all sites. The more detailed and expansive the sites are about their knowledge and sites to see, the more people are going to want to travel to as many sites as possible, learning all they can about the life of Laura Ingalls Wilder and her family. These sites not only attract Laura Ingalls Wilder fans but all people that are interested in the American Pioneer period of the United States history. This study will provide the knowledge for communities who are developing heritage tourism sites, especially those focusing on Laura Ingalls Wilder. This is a very important study for tourism and especially heritage tourism. When a heritage site is discovered communities run into the barrier of not having the experience and knowledge to develop the site properly. This study will analyze tourism in Pepin, Wisconsin to determine it's successfulness due to the fact that it is a Laura Ingalls Wilder heritage tourism site, and Wfit was developed in a way to provide tourists with a view of Laura Ingalls Wilder's past and the past of many Pioneer Americans. By studying this subject it will allow for many people to benefit. Tourist who are seeking the pleasure of the knowledge of the past, and communities who want to preserve their past and profit from tourism
Core Journal Lists: Classic Tool, New Relevance
No full textReviews the historical context of core journal lists, current uses in collection assessment, and existing methodologies for creating lists. Outlines two next generation core list projects developing new methodologies and integrating novel information/data sources to improve precision: a national-level core psychology list and the other a local institutional core list for the interdisciplinary field of urban studies and planning. The paper is based on the authors’ panel presentation at the 2009 ACRL National Conference (Seattle, Washington) titled “Core Journal Lists Re-viewed and Re-imagined.”This is an electronic version of an article published in Robin A. Paynter, Rose M. Jackson & Laura Bowering Mullen (2010): Core Journal Lists: Classic Tool, New Relevance, Behavioral & Social Sciences Librarian, 29:1, 15-31. Behavioral & Social Sciences Librarian is available online at: http://www.tandfonline.com, http://dx.doi.org/10.1080/01639260903571096Peer reviewe
Proteomic studies of formalin-fixed paraffin-embedded tissues
No full textFormalin-fixed paraffin-embedded (FFPE) tissue specimens represent a valuable informational resource of histologically characterized specimens for proteomic studies. In this article, the authors review the advancement performed in the field of FFPE proteomics focusing on formaldehyde treatment and on strategies addressed to obtain the best recovery in the protein/peptide extraction. A variety of approaches have been used to characterize protein tissue extracts, and many efforts have been performed demonstrating the comparability between fresh/frozen and FFPE proteomes. Finally, the authors report and discuss the large numbers of works aimed at developing new strategies and sophisticated platforms in the analysis of FFPE samples to validate known potential biomarkers and to discover new ones
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